Hydrogen Peroxide

Medical management of pneumoperitoneum, gastric pneumatosis, and hepatic venous gas secondary to 3% hydrogen peroxide toxicity in a dog

“…In the dog described in this report, upward of 1.2 L (195 mL/kg) of oxygen could be produced within a few seconds, significantly more than the maximum gastric capacity. 12 Generation of large volumes of oxygen in closed body cavities may result in venous or arterial gas embolization, as well as perforation of hollow viscera. Additional potential immediate complications include a vasovagal reflex arrhythmia, which has been hypothesized as the cause of death in 1 human case, as well as obstruction to venous return by mechanical compression of the caudal vena cava.…”

“…Additional potential immediate complications include a vasovagal reflex arrhythmia, which has been hypothesized as the cause of death in 1 human case, as well as obstruction to venous return by mechanical compression of the caudal vena cava. 12 When the oxygen produced exceeds the solubility in the blood, arterial and venous gas embolism occur. 12 Mucosal injury may also facilitate embolization by allowing the gas produced to come into direct contact with the underlying microvasculature.…”

“…12 When the oxygen produced exceeds the solubility in the blood, arterial and venous gas embolism occur. 12 Mucosal injury may also facilitate embolization by allowing the gas produced to come into direct contact with the underlying microvasculature. A canine experimental model demonstrated bubbles in the mesenteric circulation after colonic lavage with H 2 O 2 in concentrations as low as 0.75%.…”

“…A canine experimental model demonstrated bubbles in the mesenteric circulation after colonic lavage with H 2 O 2 in concentrations as low as 0.75%. 12 The precise conditions or toxic dose required to result in embolization is not known and likely varies highly from patient to patient. Gastric pneumatosis results from the same mechanism, and although not previously described, pneumoperitoneum could also result from the same process.…”

Electrochemical Behavior of Manganese–Molybdenum Oxide Anodes in Chloride–Sulfate Aqueous Solutions

“…1 The oxides ͑Mn 1−x Mo x ͒O 2+x •yH 2 O can be synthesized and anodically deposited on the titanium surface previously treated with noble metal oxides. Such anode materials can be used for the electrosynthesis of oxidants for medical applications [2][3][4] on manganesemolybdenum anodes instead of platinum or iridium dioxide anodes. 5 In this case, the electrolysis of chloride-containing aqueous solution could be realized.…”