Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats

Chen, Han; Sun, Yan; Yang, Li; Liu, Wenwu; Xiang, Hong Gang; Fan, Lie Ying; Sun, Qiang; Xu, Xinjian; Cai, Jianming; Ruan, Can Ping; Su, Ning; Rong, Yan; Sun, Xuejun; Wang, Qiang

doi:10.1016/j.bbrc.2010.02.005

Cited by 107 publications

(68 citation statements)

References 27 publications

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“…Cardinal et al, 25 Li et al, 26 chemotherapy complication, spinal Nagata et al, 27 Chen et cord injury al., 28 Ohsawa et al, 29 Liu et al, 17 Qian et al, 14 Nakashima-Kamimura et al, 30 Chen et al 31 …”

Section: Radiation Complication Qian Et Almentioning

confidence: 99%

“…Intestinal I/R injury, sepsis, Zheng et al, 19 Chen et pancreatitis, haemodialysis, al., 22 Chen et al, 28 Xie et obstructive jaundice, spinal cord al., 16 …”

Section: Mpomentioning

confidence: 99%

“…It was observed, however, that in biochemical studies of I/R injury, H 2 treatment was able to reduce the levels of multiple markers of oxidative stress. Notably, H 2 decreased the 36 Chen et neonatal hypoxia), chemotherapy al., 22 Cai et al, 21 Cai et complication, spinal cord injury, al., 43 Nakashimapancreatitis Kamimura et al, 30 Chen et al, 31 Chen et al 28 …”

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confidence: 99%

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Hydrogen as a Selective Antioxidant: A Review of Clinical and Experimental Studies

2010

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Oxidative stress is implicated in the pathogenesis of many diseases; however, currently used antioxidants have a high toxicity that constrains administration to a narrow window of therapeutic dosage. There is a clear need for more effective and safer antioxidants. Diatomic hydrogen (H 2 ) was proposed as a novel antioxidant that selectively reduces levels of toxic reactive-oxygen species. Recently, many studies have reported that H 2 (inhaled or orally ingested, typically as approximately 0.8 mM H 2 -saturated water), can exert beneficial effects in diverse animal models of ischaemia-reperfusion injury, and inflammatory and neurological disease. In the clinic, oral administration of H 2 -saturated water is reported to improve lipid and glucose metabolism in subjects with diabetes or impaired glucose tolerance; promising results have also been obtained in reducing inflammation in haemodialysis patients and treating metabolic syndrome. These studies suggest H 2 has selective antioxidant properties, and can exert antiapoptotic, antiinflammatory and antiallergy effects. This review summarizes recent research findings and mechanisms concerning the therapeutic potential of H 2 .

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Section: Radiation Complication Qian Et Almentioning

confidence: 99%

“…Intestinal I/R injury, sepsis, Zheng et al, 19 Chen et pancreatitis, haemodialysis, al., 22 Chen et al, 28 Xie et obstructive jaundice, spinal cord al., 16 …”

Section: Mpomentioning

confidence: 99%

mentioning

confidence: 99%

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Hydrogen as a Selective Antioxidant: A Review of Clinical and Experimental Studies

2010

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“…Recent studies reveal potential protective effects of hydrogen against sepsis and acute peritonitis by decreasing proinflammatory responses, oxidative stress, and apoptosis, which indicate hydrogen medicine as a new no-toxic therapy for bacterial infections [13,14]. Other researchers have also demonstrated that chronic hepatitis B, acute pancreatitis, and sepsis can also be alleviated by treatment of hydrogen medicine [10, 14,17]. However, none of the research ever investigated the therapeutic effect of hydrogen gas for MODS induced by influenza and other viral infectious diseases in which inflammation and oxidative stress also play pivotal roles.…”

Section: Introductionmentioning

confidence: 99%

Hydrogen Medicine Therapy: An Effective and Promising Novel Treatment for Multiple Organ Dysfunction Syndrome (MODS) Induced by Influenza and Other Viral Infections Diseases?

Hu¹

2017

SOJMID

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Hydrogen, a non-cytotoxic molecule, is one of nature's most simple elements [1,2]. Recent studies revealed that intraperitoneal injection of hydrogen-rich saline has surprising anti-inflammation, anti-oxidant, anti-apoptosis effects and protected organism against polymicrobial sepsis injury, acute peritonitis injury both by reducing oxidative stress and via decreasing mass proinflammatory responses. It is also well known that the majority of viral -induced tissue damage and discomfort are mainly caused by an inflammatory cytokine storm and oxidative stress rather than by virus itself [3][4][5]. Studies have shown that suppressing the cytokine storm and reducing oxidative stress can significantly alleviate the symptoms of influenza and other severe viral infections diseases [3][4][5][6][7]. However, none of the studies have been focused on the solution as an anti-virus infection therapy yet. Therefore, we hypothesize that hydrogen-rich solution therapy may be a safe, reliable, and effective treatment for Multiple Organ Dysfunction Syndrome (MODS) induced by influenza and other viral infectious diseases.

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“…Thus far, the precise mechanisms of action involved in H 2 protection from organ injury remain unclear, but it is thought that the H 2 molecule, which freely diffuses into cells, can react with toxic radicals, such as excess superoxide anions (O 2 − ) generated in mitochondrial respiratory complexes and hydroxyl radical [22,23,70], according to the following reactions: [71], caspase-3 [33,39], and caspase-12 [33], which would decrease proinflammatory molecule production and apoptosis. This unique characteristic of H 2 is thought to protect cells and organs from free radical injury.…”

Section: The Hydrogen Gas Molecule As a Biological Antioxidantmentioning

confidence: 99%

The hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectives

2016

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Increased oxidative stress and pro-inflammatory conditions, commonly present in chronic dialysis patients, are thought to be enhanced during hemodialysis (HD) and to be associated with the excess morbidity and mortality seen in these patients. The hydrogen molecule (H 2 ) has a unique biological capacity to act as an antioxidative and anti-inflammatory substance. In light of accumulating evidence from animal studies showing protective effects against organ damage during ischemia and inflammation, development of H 2 treatments for HD patients has become a challenging clinical goal. An HD system utilizing a water electrolysis technique that renders large amounts of H 2 -enriched water has been developed. During HD with an H 2 -enriched solution (approximately 50 ppb H 2 ), markers of increased oxidative stress (such as interleukin-6, myeloperoxidase, methemoglobin, increased lymphocyte apoptosis, and high blood pressure) are suppressed. These findings indicate that the use of an H 2 -enriched solution may prove to be a novel approach to ameliorate dialysis-related complications. This manuscript reviews the recent progress in H 2 research and the use of H 2 in HD patients, including a description of a water electrolysis technique that delivers large amounts of H 2 -enriched water for use in clinical settings.

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Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats

Cited by 107 publications

References 27 publications

Hydrogen as a Selective Antioxidant: A Review of Clinical and Experimental Studies

Hydrogen as a Selective Antioxidant: A Review of Clinical and Experimental Studies

Hydrogen Medicine Therapy: An Effective and Promising Novel Treatment for Multiple Organ Dysfunction Syndrome (MODS) Induced by Influenza and Other Viral Infections Diseases?

The hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectives

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