Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome

Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells

“…Although hydrogen gas is hard to store and handle, hydrogen-rich water (HRW) is relatively easy to use, safe, and economical for use against oxidative stress-induced damage in many in vitro and in vivo models. Accordingly, previous studies have also shown that HRW is successful for application in a number of oxidative stress-related disorders, such as metabolic syndrome [12], neurological disorders [13], and ischemia/reperfusion injuries [14]. For example, HRW was found to reduce the ischemic cerebral infarction and decreased apoptosis in hypoxia-induced brain injury [15].…”

Molecular hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor-knockout mice

“…For example, supplementation with H 2 -rich water was demonstrated to have a beneficial role in prevention of type 1 and type 2 diabetes and insulin resistance [9,10], chronic liver inflammation [11], acute liver injury [12], and focal brain ischemia/reperfusion injury [8]. In addition, we have reported that administration of H 2 -saturated saline or water decreases plasma total cholesterol (TC) and lowdensity lipoprotein cholesterol (LDL-C) levels in high-fat diet-fed hamsters [13] and patients with potential metabolic syndrome [14]. Also, we [15] and others [16] have found that consumption of H 2 -saturated saline or water prevents atherosclerosis in apolipoprotein E-knockout mice.…”

Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells

“…3 Furthermore, a clinical study of hydrogen-rich water intake found that it decreased oxidative stress and improved lipid and glucose metabolism in patients with metabolic syndrome, type 2 diabetes, and impaired glucose tolerance. [4][5][6] On the basis of these findings, H2 is now regarded as a signaling gaseous molecule with physiological activity similar to that of nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). 7 Animal studies have shown that blood concentra-…”