Hydrogen sulfide metabolism in red blood cells

Vitvitsky, Victor; Yadav, Pramod Kumar; Kurthen, Angelika; Banerjee, Ruma

doi:10.1016/j.niox.2014.09.143

Nitric Oxide

2014

DOI: 10.1016/j.niox.2014.09.143

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Hydrogen sulfide metabolism in red blood cells

Victor Vitvitsky

Pramod Kumar Yadav

Angelika Kurthen

et al.

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“…12 In red blood cells lacking mitochondria, a noncanonical sulfide oxidation route uses ferric hemoglobin and catalyzes conversion of H 2 S to thiosulfate. 13 Polysulfides that are also produced in this reaction are degraded by reductants such as glutathione. 14 Other hemeproteins like myoglobin 15 and neuroglobin 16 also catalyze ferric heme-dependent H 2 S oxidation.…”

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Cytochrome c Reduction by H₂S Potentiates Sulfide Signaling

et al. 2018

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Hydrogen sulfide (HS) is an endogenously produced gas that is toxic at high concentrations. It is eliminated by a dedicated mitochondrial sulfide oxidation pathway, which connects to the electron transfer chain at the level of complex III. Direct reduction of cytochrome c (Cyt C) by HS has been reported previously but not characterized. In this study, we demonstrate that reduction of ferric Cyt C by HS exhibits hysteretic behavior, which suggests the involvement of reactive sulfur species in the reduction process and is consistent with a reaction stoichiometry of 1.5 mol of Cyt C reduced/mol of HS oxidized. HS increases O consumption by human cells (HT29 and HepG2) treated with the complex III inhibitor antimycin A, which is consistent with the entry of sulfide-derived electrons at the level of complex IV. Cyt C-dependent HS oxidation stimulated protein persulfidation in vitro, while silencing of Cyt C expression decreased mitochondrial protein persulfidation in a cell culture. Cyt C released during apoptosis was correlated with persulfidation of procaspase 9 and with loss of its activity. These results reveal a potential role for the electron transfer chain in general, and Cyt C in particular, for potentiating sulfide-based signaling.

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Cytochrome c Reduction by H₂S Potentiates Sulfide Signaling

et al. 2018

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Hydrogen sulfide metabolism in red blood cells

Cited by 1 publication

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Cytochrome c Reduction by H₂S Potentiates Sulfide Signaling

Cytochrome c Reduction by H₂S Potentiates Sulfide Signaling

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Hydrogen sulfide metabolism in red blood cells

Cited by 1 publication

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Cytochrome c Reduction by H2S Potentiates Sulfide Signaling

Cytochrome c Reduction by H2S Potentiates Sulfide Signaling

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Cytochrome c Reduction by H₂S Potentiates Sulfide Signaling

Cytochrome c Reduction by H₂S Potentiates Sulfide Signaling