Hydrogen sulfide poisoning from toxic inhalations of roofing asphalt fumes

Hoidal, Charles R; Hall, Alan H.; Robinson, Mel D.; Kulig, Kenneth; Rumack, Barry H.

doi:10.1016/s0196-0644(86)80383-3

Cited by 45 publications

(18 citation statements)

References 19 publications

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“…High acute exposure to H 2 S leads to severe toxic effects, including death, with most deaths occurring at the scene of exposure . Although most H 2 S‐induced deaths are occupational‐related, suicide in confined spaces is a growing cause of death by H 2 S exposure …”

Section: Introductionmentioning

confidence: 99%

Cobinamide is effective for treatment of hydrogen sulfide–induced neurological sequelae in a mouse model

Anantharam

Whitley²,

Mahama

et al. 2017

Annals of the New York Academy of Sciences

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Hydrogen sulfide (H2S) is a highly neurotoxic gas. Acute exposure can lead to neurological sequelae among survivors. A drug for treating neurological sequelae in survivors of acute H2S intoxication is needed. Using a novel mouse model we evaluated the efficacy of cobinamide (Cob) for this purpose. There were two objectives: (1) to determine the dose–response efficacy of Cob and (2) to determine the effective therapeutic time window of Cob. To explore objective 1, mice were injected intramuscularly with Cob at 0, 50 or 100 mg/kg at 2 min after H2S exposure. For objective 2, mice were injected intramuscularly with 100 mg/kg Cob at 2, 15, and 30 min after H2S exposure. For both objectives, mice were exposed to 765 ppm of H2S gas. Cob significantly reduced H2S-induced lethality in a dose-dependent manner (P < 0.05). Cob-treated mice exhibited significantly fewer seizures and knockdowns compared with the H2S-exposed group. Cob also reversed H2S-induced weight loss, behavioral deficits, neurochemical changes, cytochrome c oxidase enzyme inhibition, and neurodegeneration in a dose- and time-dependent manner (P < 0.01). Overall, these findings show that Cob increases survival and is neuroprotective in a mouse model of H2S-induced neurological sequelae.

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Section: Introductionmentioning

confidence: 99%

Cobinamide is effective for treatment of hydrogen sulfide–induced neurological sequelae in a mouse model

Anantharam

Whitley²,

Mahama

et al. 2017

Annals of the New York Academy of Sciences

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“…Oxygen should be administered at the scene of the incident and in the emergency department. Amyl and sodium nitrite are often recommended and several rapid recoveries have been reported [Hoidal et al, 1986;Hall and Rumack, 1997]. However, the clinical efficacy of nitrites is unknown and their effect may wane if not initiated immediately [Beck et al, 1981].…”

Section: Discussionmentioning

confidence: 99%

Co‐worker fatalities from hydrogen sulfide

Hendrickson

Chang

Hamilton

2004

American J Industrial Med

122

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“…The concentrations of 1,000 ppm or above result in lethal situation which called a knockdown (1,2). The methods for the treatment of hydrogen sulfide poisoning include the administration of 3% sodium nitrite or hyperbaric oxygen therapy; however, the effectiveness of these methods has not yet been established (3,4 (Fig. 3A, B, C) Ca r d i a c u l t r a s o n o g r a p h y ( UCG) c h a n g e s .…”

Section: Introductionmentioning

confidence: 99%