Improvement in a Patient Suffering from Cardiac Injury Due to Severe Hydrogen Sulfide Poisoning: A Long-term Examination of the Process of Recovery of Heart Failure by Performing Nuclear Medicine Study

Amino, Mari; Yoshioka, Koichiro; Suzuki, Yosuke; Uemura, Shunryo; Sakurai, Keiji; Fukushima, Tomokazu; Morita, Seiji; Otsuka, Hiroyuki; Yamamoto, Ikuo; Kodama, Itsuo; Inokuchi, Sadaki; Tanabe, T.

doi:10.2169/internalmedicine.48.2382

Cited by 11 publications

(7 citation statements)

References 11 publications

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“…Obviously, all the benefical cardioprotective actions of H 2 S are due to low concentrations, because even recent clinical reports highlight that H 2 S poisoning causes cardiac injury due not only to local hypoxemia of the heart, but also to selective organ toxicity of the myocardium …”

Section: Major Regulatory Roles Of H2smentioning

confidence: 99%

Hydrogen sulphide: novel opportunity for drug discovery

Martelli

Testai

Breschi

et al. 2010

Medicinal Research Reviews

152

128

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Hydrogen sulphide (H(2)S) is emerging as an important endogenous modulator, which exhibits the beneficial effects of nitric oxide (NO) on the cardiovascular (CV) system, without producing toxic metabolites. H(2)S is biosynthesized in mammalian tissues by cystathionine-β-synthase and cystathionine-γ-lyase. H(2)S exhibits the antioxidant properties of inorganic and organic sulphites, behaving as a scavenger of reactive oxygen species. There is also clear evidence that H(2)S triggers other important effects, mainly mediated by the activation of ATP-sensitive potassium channels (K(ATP)). This mechanism accounts for the vasorelaxing and cardioprotective effects of H(2)S. Furthermore, H(2)S inhibits smooth muscle proliferation and platelet aggregation. In non-CV systems, H(2)S regulates the functions of the central nervous system, as well as respiratory, gastroenteric, and endocrine systems. Conversely, H(2)S deficiency contributes to the pathogenesis of hypertension. Likewise, impairment of H(2)S biosynthesis is involved in CV complications associated with diabetes mellitus. There is also evidence of a cross-talk between the H(2)S and the endothelial NO pathways. In particular, recent observations indicate a possible pathogenic link between deficiencies of H(2 S activity and the progress of endothelial dysfunction. These biological aspects of endogenous H(2)S have led several authors to look at this mediator as "the new NO" that has given attractive opportunities to develop innovative classes of drugs. In this review, the main biological actions of H(2)S are discussed. Moreover, some examples of H(2)S-donors are shown, as well as some hybrids, in which H(2)S-releasing moieties are added to well-known drugs, for improving their pharmacodynamic profile or reducing the potential for adverse effects, are reported.

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Section: Major Regulatory Roles Of H2smentioning

confidence: 99%

Hydrogen sulphide: novel opportunity for drug discovery

Martelli

Testai

Breschi

et al. 2010

Medicinal Research Reviews

152

128

View full text Add to dashboard Cite

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“…Dramatically, 1007 cases of suicide attempts with H 2 S were reported in 2008 in Japan, presumably due to the availability of information of this substance over the internet regarding a new home-made method of making the gas [4,12]. Mortality varies from 2 to 6% according to different series [13].…”

Section: Introductionmentioning

confidence: 99%

Reversal of Heart and Respiratory Failure Following Accidental Exposure to Hydrogen Sulfide: Case Report

Silva¹

2012

J Med Cases

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Risks of exposure to toxic gases are well recognized during work in sewers, the principal hazards resulting from hypoxia due to the accumulation of methane, carbon dioxide, or hydrogen sulfide and explosive risk as a result of flammable gases. Hydrogen sulfide (H 2 S) is a colourless rotten egg odour gas resulting from organic matter decomposition. The severity of H 2 S intoxication depends on the concentration and duration of exposure and the outcome may be fatal. We report the case of a 59-year-old male patient who was acutely exposed to sewers gases following an accidental leak in a swine facility nearly eighteen hours before. He presented to the emergency room with respiratory complaints and chest pain, and rapidly developed a multi-organ dysfunction syndrome with severe cardio-respiratory failure. No methaemoglobinemia was detected and H 2 S was presumed to be the major implicated toxic substance. Treatment strategy relied mostly on supportive measures with a successful outcome. Approach to victims of exposure to sewers gases should recall the strong possibility of poisoning by H 2 S, a life-threatening condition. Since laboratorial dosing of sulfide compounds is not readily available, the initial approach is based on a high clinical suspicion. H 2 S direct toxicity and cellular hypoxic induction may rapidly lead to multi-organic dysfunction and death. Evidence from case reports suggests that early treatment with nitrites, hyperbaric oxygen therapy and hydroxocobalamin may be beneficial. To the present date, supportive treatment remains the mainstay of care.

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“…The ECG changes exhibited were likely contributed to by the hyperkaelamia, however the trend towards, and eventual normalisation, of serum potassium levels pre-and peri-cardiac arrest, suggests that other factors may have played a role. Previous studies have suggested that myocardial toxicity in H 2 S poisoning can be secondary to cellular hypoxia and also selective organ toxicity for the myocardium [9]. Due to the rise in serum troponin level and ST elevation exhibited on the ECG it is likely that our patient had a myocardial infarction and this may have ultimately been the cause of his death.…”

Section: Discussionmentioning

confidence: 84%

A case of suicide by hydrogen sulphide poisoning in the UK

2016

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Hydrogen sulphide is a colourless, flammable gas with the characteristic odour of rotten eggs. Inhalation of hydrogen sulphide is toxic to humans as it inhibits aerobic metabolism resulting in cellular hypoxia and lactic acidosis. Cases of hydrogen sulphide poisoning in the United Kingdom (UK) are usually occupational in nature occurring via accidental exposure in related industries. Although national statistical data identified 14 cases of suicide by hydrogen sulphide gas in England and Wales between 2001 and 2011, none of these have been previously published. We present the first case of suicide by hydrogen sulphide poisoning in the UK reported in the medical literature.

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Improvement in a Patient Suffering from Cardiac Injury Due to Severe Hydrogen Sulfide Poisoning: A Long-term Examination of the Process of Recovery of Heart Failure by Performing Nuclear Medicine Study

Abstract: Abstract

Cited by 11 publications

References 11 publications

Hydrogen sulphide: novel opportunity for drug discovery

Hydrogen sulphide: novel opportunity for drug discovery

Reversal of Heart and Respiratory Failure Following Accidental Exposure to Hydrogen Sulfide: Case Report

A case of suicide by hydrogen sulphide poisoning in the UK

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