Hydrolysis improves the inhibition efficacy of bovine lactoferrin against infection by SARS-CoV-2 pseudovirus

Inhibitory effect of lactoferrin-coated zinc nanoparticles on SARS-CoV-2 replication and entry along with improvement of lung fibrosis induced in adult male albino rats

“…Cat L is a viral protease that facilitates the cleavage of the viral spike glycoprotein's S1 component to inject the viral RNA inside the host cells for subsequent replication [ 63 , 64 ]. Several studies reported the ability of Lf to target Cat L activity, especially through the carboxyl-terminal lobe of the intact Lf structure [ 65 , 66 ]. Furthermore, the RdRp proteins are well-known targets for antiviral drugs in most RNA viruses, with several antiviral drugs already in clinical trials [ 67 ].…”

The development and application of pseudoviruses: assessment of SARS-CoV-2 pseudoviruses

“… Patil et al (2023) constructed HIV-1-based SARS-CoV-2 pseudovirus to evaluate that Lactoferin hydrolysed for 90 min inhibits on CTSL and prevents the pseudovirus from entering target cells. [Pyr1]-Apelin-13 can bind to ACE2, inhibit the binding of S protein and cell ACE2, and effectively reduce the pseudovirus infection to 16HBE14o cells ( Park et al, 2022 ).…”