“…The study of ester hydrolysis catalysts has been used as a starting point for more challenging hydrolysis reactions, 11 and has important practical applications itself, 12 such as in the depolymerization of polyester plastics. 13,14 Peptide ester hydrolysis catalysts have been reported using a variety of structural scaffolds including b-hairpins, 7,15,16 polyproline helices, 9,17 ahelices, 5 cyclic peptides, 18 dendrimers, 19 and more. 20 Further investigation of the effect of secondary structure is important for determining the role of conformation on catalysis and in guiding the design of future catalysts.…”