Hydronephrosis Resulting from Bilateral Ureteral Stenosis: A Late Complication of Polyoma BK Virus Cystitis?

Basara, Nadežda; Rasche, Franz Maximilian; Schwalenberg, Thilo; Wickenhauser, Claudia; Maier, Marc A.; Ivovic, J.; Niederwieser, D.; Lindner, Tom H.

doi:10.1155/2010/297358

Cited by 11 publications

(2 citation statements)

References 24 publications

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“…More rarely, BKV nephropathy is documented. Although BKV is by far the most common cause of hemorrhagic cystitis after allogeneic stem cell transplantation [12], only very few reports have previously described the possibility of upper urinary tract obstruction in this setting [4, 16]. …”

Section: Discussionmentioning

confidence: 99%

Reversible Ureteral Obstruction due to Polyomavirus Infection after Percutaneous Nephrostomy Catheter Placement

Khan

Oberoi

Mahvash

et al. 2011

Biology of Blood and Marrow Transplantation

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BK virus (BKV) is a human polyomavirus which remains latent in the urinary tract epithelium in most individuals. However, in immunocompromised states, including post hematopoietic stem cell transplantation (HSCT), BKV may reactivate and cause infection, predominantly affecting the bladder, commonly manifested as hemorrhagic cystitis. Renal insufficiency, occasionally requiring hemodialysis, is not uncommon, and was previously attributed to medications or the development of tubulointestitial nephritis. We report a series of 6 HSCT recipients who developed obstructive uropathy of the upper urinary tract system secondary to inflammation and hemorrhage involving the upper uroepithelium, causing ureteral stenosis. Temporary percutaneous nephrostomy catheter placement relieved the obstruction and improved significantly the kidney function, successfully preventing progression to more advanced renal disease in these patients.

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Section: Discussionmentioning

confidence: 99%

Reversible Ureteral Obstruction due to Polyomavirus Infection after Percutaneous Nephrostomy Catheter Placement

Khan

Oberoi

Mahvash

et al. 2011

Biology of Blood and Marrow Transplantation

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“…4,5 The incidence of BKPyV viruria has been reported to range from 46% to 53% in allogeneic SCT recipients and from 39% to 54% in autologous SCT recipients.. 6 Approximately 8% to 25% of children and 7% to 54% of adults with BKPyV viruria develop symptomatic BKPyV infections. 1,7 Symptomatic BKPyV infection manifests as hemorrhagic and nonhemorrhagic cystitis (HC), 8 ureteric stenosis, 8,9 and nephritis. 10 Any cause HC has been reported as high as 70% of hematopoietic SCT recipients and is associated with prolonged hospitalization, and leads to severe hematuria in 8% to 27% of affected patients.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a risk assessment tool for BKPyV Replication in allogeneic stem cell transplant recipients

Abudayyeh

Lin

Abdelrahim

et al. 2020

Transplant Infectious Dis

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Background: BK polymavirus (BKPyV), a member of the family Polyomaviridae, is associated with increased morbidity and mortality in allogeneic stem cell transplant recipients. Methods: In our previous retrospective study of 2477 stem cell transplant patients, BKPyV replication independently predicted chronic kidney disease and poor survival. In this study, using the same cohort, we derived and validated a risk grading system to identify patients at risk of BKPyV replication after transplantation in a user-friendly modality. We used 3 baseline variables (conditioning regimen, HLA match status, and underlying cancer diagnosis) that significantly predicted BKPyV replication in our initial study in a subdistribution hazard model with death as a competing risk. We also developed a nomogram of the hazard model as a visual aid. The AUC of the ROC of the risk-score-only model was 0.65. We further stratified the patients on the basis of risk score into low-, moderate-, and high-risk groups. Results: The total risk score was significantly associated with BKPyV replication (P < .0001). At 30 days after transplantation, the low-risk (score ≤ 0) patients had a 9% chance of developing symptomatic BKPyV replication, while the high-risk (score ≥ 8) of the population had 56% of developing BKPyV replication. We validated the risk score using a separate cohort of 1478 patients. The AUC of the ROC of the risk-score-only model was 0.59. Both the total risk score and 3-level risk variable were significantly associated with BKPyV replication in this cohort (P < .0001). Conclusions: This grading system for the risk of symptomatic BKPyV replication may help in early monitoring and intervention to prevent BKPyV-associated morbidity, mortality, and kidney function decline.

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Human Adenovirus, Polyomavirus, and Parvovirus Infections in Patients Undergoing Hematopoietic Stem Cell Transplantation

Hirsch

Pergam

2015

Thomas’ Hematopoietic Cell Transplantation

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Hydronephrosis Resulting from Bilateral Ureteral Stenosis: A Late Complication of Polyoma BK Virus Cystitis?

Cited by 11 publications

References 24 publications

Reversible Ureteral Obstruction due to Polyomavirus Infection after Percutaneous Nephrostomy Catheter Placement

Reversible Ureteral Obstruction due to Polyomavirus Infection after Percutaneous Nephrostomy Catheter Placement

Development and validation of a risk assessment tool for BKPyV Replication in allogeneic stem cell transplant recipients

Human Adenovirus, Polyomavirus, and Parvovirus Infections in Patients Undergoing Hematopoietic Stem Cell Transplantation

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