Hydrophilic bismuth sulfur nanoflower superstructures with an improved photothermal efficiency for ablation of cancer cells

A theranostic platform combining synergistic therapy and real-time imaging attracts enormous attention but still faces great challenges, such as tedious modifications and lack of efficient accumulation in tumor. Here, a novel type of theranostic agent, bismuth sulfide@mesoporous silica (Bi2S3@ mPS) core-shell nanoparticles (NPs), for targeted image-guided therapy of human epidermal growth factor receptor-2 (HER-2) positive breast cancer is developed. To generate such NPs, polyvinylpyrrolidone decorated rod-like Bi2S3 NPs are chemically encapsulated with a mesoporous silica (mPS) layer and loaded with an anticancer drug, doxorubicin. The resultant NPs are then chemically conjugated with trastuzumab (Tam, a monoclonal antibody targeting HER-2 overexpressed breast cancer cells) to form Tam-Bi2S3@mPS NPs. By in vitro and in vivo studies, it is demonstrated that the Tam-Bi2S3@mPS bear multiple desired features for cancer theranostics, including good biocompatibility and drug loading ability as well as precise and active tumor targeting and accumulation (with a bismuth content in tumor being ≈16 times that of nontargeted group). They can simultaneously serve both as an excellent contrast enhancement probe (due to the presence of strong X-ray-attenuating bismuth element) for computed tomography deep tissue tumor imaging and as a therapeutic agent to destruct tumors and prevent metastasis by synergistic photothermalchemo therapy.

show abstract

“…[18] Meanwhile, bismuth sulfide NPs with a wide range of size from 5 to 300 nm have also been investigated for in vivo CT imaging. [19] …”

Section: Introductionmentioning

confidence: 99%

Actively Targeted Deep Tissue Imaging and Photothermal‐Chemo Therapy of Breast Cancer by Antibody‐Functionalized Drug‐Loaded X‐Ray‐Responsive Bismuth Sulfide@Mesoporous Silica Core–Shell Nanoparticles

Jiang

et al. 2017

Adv Funct Materials

129

101

View full text Add to dashboard Cite

show abstract

“…40 Larger optical absorption efficiency, higher crystallinity, smaller photocatalysts are beneficial to the photocatalytic activity due to the increase of photoelectrons and holes, charge separation, and more catalytic sites. 42 Thus, it is important to investigate the relationship between properties and structures of materials. Photothermal conversion efficiency of plasmonic semiconductors is also influenced by the plasmon resonance wavelength, composite, morphology, surface coating, and crystalline structure.…”

Section: Introductionmentioning

confidence: 99%

Structural evolution from CuS nanoflowers to Cu₉S₅ nanosheets and their applications in environmental pollution removal and photothermal conversion

Tao

Zhang

et al. 2016

RSC Adv.

View full text Add to dashboard Cite

Three-dimensional (3D) CuS nanoflowers and 2D single crystalline Cu9S5 nanosheets with irregular hexagonal holes had been successfully synthesized by easily hydrothermal treating the solution of copper dichloride dihydrates and thiourea at 180 o C for several hours without any surfactants and morphology-controlled agents. Irregularly hexagonal holes were widely distributed over the Cu9S5 nanosheets, which could efficiently enlarge the surface area. The UV-Vis-NIR absorption spectroscopy showed an obvious increase of the near-IR absorbance. The influence of the reaction time, morphology, and crystal phase on the photocatalysis and photothermal conversion was discussed. The results revealed that CuS nanoflowers displayed the maximum removal value of rhodamine B by 67%. The Cu9S5 nanosheets obtained with the increase reaction time displayed adsorption and photo-degradation decrease for RhB. The exposure of the aqueous dispersion of the Cu9S5 nanosheets prepared with 6 h (2.0 g/L) under the irradiation of 980 nm laser can increase its temperature by 25.1 o C in 600 s, exhibiting a good photothermal conversion performance. The photothermal efficacy increases with the samples obtained from 1 h to 18 h.

show abstract

“…Recently, Bi 2 S 3 nanobelts [ 44 ] with a bandgap of 1.22 eV was introduced. By assembling the crumpled‐paper‐like NSs to form 3D Bi 2 S 3 nanoflowers, the bandgap value decreased to 0.8 eV (Figure 8f).…”

Section: Classification and Characteristics Of Major Cancer Monotheramentioning

confidence: 99%

Bismuth‐Based Nanomaterials: Recent Advances in Tumor Targeting and Synergistic Cancer Therapy Techniques

Badrigilan

Choupani

Khanbabaei

et al. 2020

Adv Healthcare Materials

View full text Add to dashboard Cite

Despite all of the efforts in the field of cancer therapy, the heterogeneous properties of tumor cells induce an insufficient therapeutic outcome when treated with conventional monotherapies, necessitating a shift in cancer treatment from monotherapy to combination therapy for complete cancer treatment. Multifunctional bismuth (Bi)‐based nanomaterials (NMs) with therapeutic functions hold great promise for the fields of cancer diagnosis and therapy based on their low toxicity, X‐ray sensitive capabilities, high atomic number, near‐infrared driven semiconductor properties, and low cost. Herein, a comprehensive review of recent advances in various medicinal aspects of Bi‐based NMs is presented including: evaluation of in‐tumor site accumulation, tumor targeting, and therapeutic performance, as well as the characteristics, benefits, and shortcomings of Bi‐based NM‐mediated major monotherapies. In addition, the cooperative enhancement mechanisms between two or more of these monotherapies are described in detail to address common challenges in cancer therapy, such as multidrug resistance, hypoxia, and metastasis. Finally, this review opens new insights into the design of multimodal synergistic therapies for potential future clinical applications of Bi‐based NMs.

show abstract

Hydrophilic bismuth sulfur nanoflower superstructures with an improved photothermal efficiency for ablation of cancer cells

Cited by 83 publications

References 63 publications

Actively Targeted Deep Tissue Imaging and Photothermal‐Chemo Therapy of Breast Cancer by Antibody‐Functionalized Drug‐Loaded X‐Ray‐Responsive Bismuth Sulfide@Mesoporous Silica Core–Shell Nanoparticles

Actively Targeted Deep Tissue Imaging and Photothermal‐Chemo Therapy of Breast Cancer by Antibody‐Functionalized Drug‐Loaded X‐Ray‐Responsive Bismuth Sulfide@Mesoporous Silica Core–Shell Nanoparticles

Structural evolution from CuS nanoflowers to Cu₉S₅ nanosheets and their applications in environmental pollution removal and photothermal conversion

Bismuth‐Based Nanomaterials: Recent Advances in Tumor Targeting and Synergistic Cancer Therapy Techniques

Contact Info

Product

Resources

About

Hydrophilic bismuth sulfur nanoflower superstructures with an improved photothermal efficiency for ablation of cancer cells

Cited by 83 publications

References 63 publications

Actively Targeted Deep Tissue Imaging and Photothermal‐Chemo Therapy of Breast Cancer by Antibody‐Functionalized Drug‐Loaded X‐Ray‐Responsive Bismuth Sulfide@Mesoporous Silica Core–Shell Nanoparticles

Actively Targeted Deep Tissue Imaging and Photothermal‐Chemo Therapy of Breast Cancer by Antibody‐Functionalized Drug‐Loaded X‐Ray‐Responsive Bismuth Sulfide@Mesoporous Silica Core–Shell Nanoparticles

Structural evolution from CuS nanoflowers to Cu9S5 nanosheets and their applications in environmental pollution removal and photothermal conversion

Bismuth‐Based Nanomaterials: Recent Advances in Tumor Targeting and Synergistic Cancer Therapy Techniques

Contact Info

Product

Resources

About

Structural evolution from CuS nanoflowers to Cu₉S₅ nanosheets and their applications in environmental pollution removal and photothermal conversion