Hydrophilic Chlorin e6-Poly(amidoamine) Dendrimer Nanoconjugates for Enhanced Photodynamic Therapy

Lee, So-Ri; Kim, Young‐Jin

doi:10.3390/nano8060445

Cited by 23 publications

(14 citation statements)

References 18 publications

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“…Therefore, to verify the enhanced bioactivity of the CEPP20 monolith, 1 O2 generation from the CEPP monoliths during laser irradiation was quantitatively determined using 9,10-dimethylanthracene (DMA) as the 1 O2 chemical probe. Fluorescent DMA reacts selectively with the 1 O2 to form endoperoxide, causing a reduction in the fluorescence of DMA [25]. The 1 O2 formation from the CEPP monoliths increased with increasing immobilized PpIX content on the monolith surface.…”

Section: In Vitro Bioactivity Of the Cepp Monolithmentioning

confidence: 99%

Photodynamic Activity of Protoporphyrin IX-Immobilized Cellulose Monolith for Nerve Tissue Regeneration

Lee

Kim

Kwon

et al. 2022

IJMS

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The development of nerve conduits with a three-dimensional porous structure has attracted great attention as they closely mimic the major features of the natural extracellular matrix of the nerve tissue. As low levels of reactive oxygen species (ROS) function as signaling molecules to promote cell proliferation and growth, this study aimed to fabricate protoporphyrin IX (PpIX)-immobilized cellulose (CEPP) monoliths as a means to both guide and stimulate nerve regeneration. CEPP monoliths can be fabricated via a simple thermally induced phase separation method and surface modification. The improved nerve tissue regeneration of CEPP monoliths was achieved by the activation of mitogen-activated protein kinases, such as extracellular signal-regulated kinases (ERKs). The resulting CEPP monoliths exhibited interconnected microporous structures and uniform morphology. The results of in vitro bioactivity assays demonstrated that the CEPP monoliths with under 0.54 ± 0.07 μmol/g PpIX exhibited enhanced photodynamic activity on Schwann cells via the generation of low levels of ROS. This photodynamic activation of the CEPP monoliths is a cell-safe process to stimulate cell proliferation without cytotoxic side effects. In addition, the protein expression of phospho-ERK increased considerably after the laser irradiation on the CEPP monoliths with low content of PpIX. Therefore, the CEPP monoliths have a potential application in nerve tissue regeneration as new nerve conduits.

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Section: In Vitro Bioactivity Of the Cepp Monolithmentioning

confidence: 99%

Photodynamic Activity of Protoporphyrin IX-Immobilized Cellulose Monolith for Nerve Tissue Regeneration

Lee

Kim

Kwon

et al. 2022

IJMS

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“…[ 227 ] In another work, PAMAM dendrimers conjugated to Ce6 were also shown to be potent nanophotosensitizers in vitro against human cervical cancer cells, inducing photoactivated apoptosis in a more effective way than Ce6 alone. [ 228 ]…”

Section: Nanotechnology and Chlorophyll Derivativesmentioning

confidence: 99%

Light‐Activated Biomedical Applications of Chlorophyll Derivatives

Pucci

Martinelli

Degl’Innocenti

et al. 2021

Macromolecular Bioscience

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Tetrapyrroles are the basis of essential physiological functions in most living organisms. These compounds represent the basic scaffold of porphyrins, chlorophylls, and bacteriochlorophylls, among others. Chlorophyll derivatives, obtained by the natural or artificial degradation of chlorophylls, present unique properties, holding great potential in the scientific and medical fields. Indeed, they can act as cancer‐preventing agents, antimutagens, apoptosis inducers, efficient antioxidants, as well as antimicrobial and immunomodulatory molecules. Moreover, thanks to their peculiar optical properties, they can be exploited as photosensitizers for photodynamic therapy and as vision enhancers. Most of these molecules, however, are highly hydrophobic and poorly soluble in biological fluids, and may display undesired toxicity due to accumulation in healthy tissues. The advent of nanomedicine has prompted the development of nanoparticles acting as carriers for chlorophyll derivatives, facilitating their targeted administration with demonstrated applicability in diagnosis and therapy. In this review, the chemical and physical properties of chlorophyll derivatives that justify their usage in the biomedical field, with particular regard to light‐activated dynamics are described. Their role as antioxidants and photoactive agents are discussed, introducing the most recent nanomedical applications and focusing on inorganic and organic nanocarriers exploited in vitro and in vivo.

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“…To overcome the drawbacks of poor water solubility and undesirable cell localization of Ce6, Lee et al designed a novel hydrophilic nano‐copolymer (DC) with poly‐amidoamine dendrimers. The spherical DC with an average particle size of 61.7 nm displayed not only better cellular uptake but also stronger cytotoxicity than Ce6 alone (Lee & Kim, 2018 ).…”

Section: Drug Delivery For Cervical Caner Via Nanomaterialsmentioning

confidence: 99%

Nanoparticle‐based applications for cervical cancer treatment in drug delivery, gene editing, and therapeutic cancer vaccines

Zhou

Liu

Cheng

et al. 2021

WIREs Nanomed Nanobiotechnol

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Cervical cancer is a leading cause of gynecological tumor related deaths worldwide. The applications of conventional approaches such as chemoradiotherapy and surgery are restricted due to their side effects and drug resistances. Although immune checkpoint inhibitors (ICIs) have emerged as novel choices, their clinical response rates are rather limited. To date there is a lack of effective treatment regimens for patients with metastatic or recurrent cervical cancer. Recently nanomaterials like liposomes, dendrimers, and polymers are considered as promising delivery carriers with advantages of tumor‐specific administration, reduced toxicity, and improved biocompatibility. Here, we review the applications of nanoparticles in the fields of drug delivery, CRISPR based genome‐editing and therapeutic vaccines in cervical cancer treatment. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Hydrophilic Chlorin e6-Poly(amidoamine) Dendrimer Nanoconjugates for Enhanced Photodynamic Therapy

Cited by 23 publications

References 18 publications

Photodynamic Activity of Protoporphyrin IX-Immobilized Cellulose Monolith for Nerve Tissue Regeneration

Photodynamic Activity of Protoporphyrin IX-Immobilized Cellulose Monolith for Nerve Tissue Regeneration

Light‐Activated Biomedical Applications of Chlorophyll Derivatives

Nanoparticle‐based applications for cervical cancer treatment in drug delivery, gene editing, and therapeutic cancer vaccines

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