Hydrophilic hybrid IPNs of segmented polyurethanes and copolymers of vinylpyrrolidone for applications in medicine

Abraham, Gustavo Abel; Queiroz, Álvaro Antônio Alencar de; Román, Julio San

doi:10.1016/s0142-9612(00)00381-1

Cited by 79 publications

(39 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most important factors which affect SPU biocompatibility are the protein adsorption and cellular interactions that will occur at the biomaterial-tissue interface [27]. The study of in vitro and in vivo cellular behavior at the interface of synthetic materials used for implantable devices or cell culture scaffolds is fundamental.…”

Section: Introductionmentioning

confidence: 99%

Segmented poly(esterurethane urea)s from novel urea–diol chain extenders: Synthesis, characterization and in vitro biological properties

et al. 2008

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Segmented poly(esterurethane urea)s from novel urea–diol chain extenders: Synthesis, characterization and in vitro biological properties

et al. 2008

View full text Add to dashboard Cite

“…26,27 VP has also been tested for the release of the nonsteroidal anti-inflammatory drug 2 0 4 0 -difluoro-4-hydroxy-(1,1 0 biphenyl)-3-carboxylic acid 28 and the immunosuppressor cyclosporine A. 29 The proteic 30 and blood 31 interactions of copolymers of VP have also been studied.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, bioactivity and biocompatibility of nanostructured materials based on the wollastonite‐poly(ethylmethacrylate‐co‐vinylpyrrolidone) system

Rodríguez‐Lorenzo

Carrodeguas

Rodrı́guez

et al. 2008

J Biomedical Materials Res

View full text Add to dashboard Cite

Composite materials are very promising biomaterials for hard tissue augmentation. The approach assayed in this work involves the manufacturing of a composite made of a bioactive ceramic, natural wollastonite (W) and a nanostructured copolymer of ethylmethacrylate (EMA) and vinylpyrrolidone (VP) to yield a bioresorbable and biocompatible VP-EMA copolymer. A bulk polymerization was induced thermally at 50 degrees C, using 1 wt % azobis(isobutyronitrile) (AIBN) as free-radical initiator. Structural characterization, compressive strength, flexural strength (FS), degradation, bioactivity, and biocompatibility were evaluated in specimens with a 60/40 VP/EMA ratio and ceramic content in the range 0-60%. A good integration between phases was achieved. Greater compression and FS, in comparison with the pure copolymer specimens was obtained only when the ceramic load got up to 60% of the total weight. The soaking in NaCl solution resulted in the initial swelling of the specimens tested. The maximum swelling was reached after 2-3 h of immersion and it was significantly greater for lower ceramic loads. This result makes the polymer component the main responsible for the interactions with the media. After soaking in SBF, microdomains segregation can be observed in the polymer component that can be related with a dramatic difference in the reactivity of both monomers in free radical polymerization, whereas the formation of an apatite-like layer on the W surfaces can be observed. Biocompatibility in vitro studies showed the absence of cytotoxicity of all formulations. The cells were able to adhere on the polystyrene negative control and on specimens containing 60 wt % wollastonite forming a monolayer and showing a normal morphology. However, a low cellular growth was observed.

show abstract

“…It is widely used in coating, foam, textile, thermoplastic elastomers, medical equipment, etc. [1][2][3][4][5][6]. Traditional polyurethane coatings contain a great deal of organic solvents which destroys the environment around us and endangers life.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of waterborne polyurethane/organic clay nanocomposites

Wang

2008

Front. Mater. Sci. China

View full text Add to dashboard Cite

Stable waterborne polyurethane/organic clay latex was synthesized by ultrasonically-assisted mixing with different clay content. Fourier transform infrared (FT-IR) spectra showed that the interaction between NH and C5O was enhanced with low content organic clay loaded. X-ray diffraction (XRD) results implied that the layered organic clay was exfoliated and the crystallization of the hard domain in the waterborne polyurethane (WPU) matrix was enhanced. Transmission electron microscopy (TEM) images show that the layered clay was exfoliated by WPU molecule. The tensile test shows that the mechanical properties were improved by loading organic clay and the desired addition was 1 wt.%.

show abstract

Hydrophilic hybrid IPNs of segmented polyurethanes and copolymers of vinylpyrrolidone for applications in medicine

Cited by 79 publications

References 63 publications

Segmented poly(esterurethane urea)s from novel urea–diol chain extenders: Synthesis, characterization and in vitro biological properties

Segmented poly(esterurethane urea)s from novel urea–diol chain extenders: Synthesis, characterization and in vitro biological properties

Synthesis, characterization, bioactivity and biocompatibility of nanostructured materials based on the wollastonite‐poly(ethylmethacrylate‐co‐vinylpyrrolidone) system

Synthesis and characterization of waterborne polyurethane/organic clay nanocomposites

Contact Info

Product

Resources

About