Hydrophilic modification of silica–titania mesoporous materials as restricted-access matrix adsorbents for enrichment of phosphopeptides

Dendritic Mesoporous Silica Nanoparticles with Abundant Ti4+ for Phosphopeptide Enrichment from Cancer Cells with 96% Specificity

“…The enrichment selectivity of IMAC materials mainly depends on the hydrophilicity of materials and the amount of the immobilized metal ions. On one hand, phosphopeptides show higher hydrophilicity than other peptides; − thus, increasing the hydrophilicity of the materials can improve the enrichment selectivity of phosphopeptides. On the other hand, IMAC materials primarily rely on the electrostatic interactions between phosphate groups and metal ions (e.g., Ti 4+ , Fe 3+ , Zn 2+ , Ga 3+ , and Zr 4+ ); − thus, the more the immobilized metal ions, the better the enrichment selectivity.…”

Amine-functionalized TiO 2 nanoparticles for highly selective enrichment of phosphopeptides

“…In addition, hydrophilic modification of silica-titania mesoporous materials are also synthesized to improve the water solubility of silica-titania materials in the process of the enhancement of phosphopeptides [16,17]. However, the above two defects of TiO 2 in the enrichment of phosphopeptides are still not solved at the same time based on a material.…”

Nanostructured alkyl carboxylic acid-based restricted access solvents: Application to the combined microextraction and cleanup of polycyclic aromatic hydrocarbons in mosses

“…and that favors increased sample throughput [2,3]. The latest advances in this field have been mainly related to the development of simpler procedures for the synthesis of RAMs [4,5] and the design of more selective materials [6,7].…”