Hydrophobic Fractions of Triticum aestivum L. Extracts Contain Polyphenols and Alleviate Inflammation by Regulating Nuclear Factor-kappa B

Choi, Moon‐Hee; Lee, Min Young; Yang, Seung-Hwa; Shin, Hyun‐Jae; Jeon, Young Jin

doi:10.1007/s12257-020-0352-7

Cited by 10 publications

(7 citation statements)

References 56 publications

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“…Activated IKK phosphorylates and phosphorylated IκB are degraded and released from NF-κB [42]. NF-κB is activated and translocated to the nucleus, where it functions as a transcription factor [43]. In our study, NF-κB phosphorylation was increased by UV CM but suppressed by Rg2 (50 µM) (Fig.…”

Section: Discussionsupporting

confidence: 50%

The ginsenoside Rg2 downregulates MMP-1 expression in keratinocyte (HaCaT)-conditioned medium-treated human fibroblasts (Hs68)

Oh,

Park,

Lee

et al. 2023

Appl Biol Chem

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Keratinocytes exposed to UVB induce the production of cytokines, which activate fibroblasts and increase the expression of matrix metalloproteinases (MMPs). The increased expression of MMPs leads to connective tissue damage and wrinkle formation, resulting in skin aging. In this study, we used human dermal fibroblasts cultured in UVB-irradiated keratinocyte-conditioned medium (UV CM) to investigate the potential anti-aging effects of the ginsenoside Rg2 on skin. The inhibitory effect of Rg2 on the MMP-1 gene and protein was determined by real-time PCR and ELISA. We also examined the expression levels of proteins in the mitogen-activated protein kinase (MAPK) signaling pathway using western blotting, to elucidate the underlying mechanism of the inhibitory effect of Rg2. Rg2 inhibited MMP-1 mRNA and protein expression in a concentration-dependent manner. We found that Rg2 inhibited the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) but not that of p38. Therefore, our results suggest that Rg2 is a potential material for the prevention and treatment of photoaging.

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Section: Discussionsupporting

confidence: 50%

The ginsenoside Rg2 downregulates MMP-1 expression in keratinocyte (HaCaT)-conditioned medium-treated human fibroblasts (Hs68)

Oh,

Park,

Lee

et al. 2023

Appl Biol Chem

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“…Choi et al [ 111 ] studied the anti-inflammatory properties of 80% ethanolic wheatgrass extract fractionated into ethyl acetate and n-butanol fractions. The HPLC analysis elucidated the presence of benzoic acid, quercetin, and luteolin abundantly.…”

Section: Resultsmentioning

confidence: 99%

General Health Benefits and Pharmacological Activities of Triticum aestivum L.

et al. 2022

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Common wheat (Triticum aestivum), one of the world’s most consumed cereal grains, is known for its uses in baking and cooking in addition to its medicinal uses. As this plant’s medical benefits are enormous and scattered, this narrative review was aimed at describing the pharmacological activities, phytochemistry, and the nutritional values of Triticum aestivum. It is a good source of dietary fiber, resistant starch, phenolic acids, alkylresorcinols, lignans, and diverse antioxidant compounds such as carotenoids, tocopherols and tocotrienols. These constituents provide Triticum aestivum with a wide range of pharmacological properties, including anticancer, antimicrobial, antidiabetic, hypolipemic, antioxidant, laxative, and moisturizing effects. This review summarized the established benefits of wheat in human health, the mode of action, and different clinical, in vitro and in vivo studies for different varieties and cultivars. This review also gives an insight for future research into the better use of this plant as a functional food. More clinical trials, in vivo and in vitro studies are warranted to broaden the knowledge about the effect of Triticum aestivum on nutrition-related diseases prevention, and physical and mental well-being sustenance.

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“…Yapılan çalışmalarda buğday çimi suyunda tanımlanan fenolikler bileşenler; kateşin, epikateşin, rutin, kuersetin, izokuersetin, apigenin-7-glukozit, apigenin, viteksin, izoviteksin, kaempferol, luteolin, pirogallol, krizin, vanilik asit, ellagik asit, gallik asit, protokatekuik asit, p-hidroksibenzoik asit, gentisik asit, siringik asit, ferulik asit, klorojenik asit, p-kumarik asit, kafeik asit, skopoletin, sinapik asit ve ros-marinik asit olarak belirlenmiş. Ayrıca polifenolik öncü bileşik olan sinamik asit ve resveratol de bulunmuştur (11,(19)(20)(21)(22)(23)(24).…”

Section: Discussionunclassified

Effect of Wheatgrass on Human Lymphocyte Cells

Sancer

Öz

KOŞAR

2023

SDÜ Tıp Fakültesi Dergisi

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Amaç: Kemoterapötik ilaçlar kanser hücrelerinin ortadan kaldırılmasında etkili iken aynı zamanda sağlıklı hücrelerde de hasar oluşturabilmektedir. Bu çalışmada, buğday çimi (Triticum aestivum L.) ekstraktının fenolik bileşen içeriğinin analizi ve bu ekstraktın kemoterapötik tedavide kullanılan sisplatin ve etoposid’in sağlıklı hücrelerde oluşturduğu DNA hasarına karşı etkisinin belirlenmesi amaçlanmıştır. Gereç ve Yöntemler: Çimlendirilmiş buğdayların metanol ekstraktı hazırlanarak HPLC (yüksek performanslı sıvı kromatografisi) ile fenolik bileşen analizi yapıldı. Buğday ekstraktı konsantrasyonuna bağlı hücre canlılık testi uygulanarak IC50 (Yarı maksimum inhibitör konsantrasyonu) ve LD50 (ortalama öldürücü doz) değerleri hesaplandı. Belirlenen bu konsantrasyon değerleri ile hücreler inkübe edilerek DNA hasarı varlığı Comet metodu ile değerlendirildi. Bulgular: Fenolik bileşen analizi sonucunda p-hidroksibenzoik asit en yüksek miktarda, o-kumarik asit ise en düşük düzeyde tespit edildi. Lenfosit hücrelerine uygulanan farklı konsantrasyonlardaki buğday çimi ekstraktı, etoposid ve sisplatin için değerler sırasıyla IC50=204,6 µg/mL, LD50=15,84 µg/mL ve LD50=24,51 µg/mL olarak bulundu. Comet analizi sonucunda kontrol grubuna kıyasla, etoposid LD50 ve etoposid LD50+buğday çimi ekstraktı IC50 grubu istatistiksel olarak anlamlı bulunurken (p>0,05), etoposid LD50 ve etoposid LD50+buğday çimi ekstraktı IC50 grubu arasında istatistiksel olarak anlamlılık bulunamadı (p>0,05). Bu sonuca benzer olarak kontrol grubuna kıyasla, sisplatin LD50 ve sisplatin LD50+buğday çimi ekstraktı IC50 grubu istatistiksel olarak anlamlı bulunurken (p>0,05), etoposid LD50 ve etoposid LD50+buğday çimi ekstraktı IC50 grubu arasında istatistiksel olarak anlamlılık saptanmadı (p>0,05). Sonuç: Çalışmamızda buğday çiminin etoposid ve sisplatin nedeni le oluşan DNA hasarında azalmaya neden olduğu görülmüş olmasına rağmen istatistiksel olarak anlamlılık saptanmamıştır.

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Hydrophobic Fractions of Triticum aestivum L. Extracts Contain Polyphenols and Alleviate Inflammation by Regulating Nuclear Factor-kappa B

Cited by 10 publications

References 56 publications

The ginsenoside Rg2 downregulates MMP-1 expression in keratinocyte (HaCaT)-conditioned medium-treated human fibroblasts (Hs68)

The ginsenoside Rg2 downregulates MMP-1 expression in keratinocyte (HaCaT)-conditioned medium-treated human fibroblasts (Hs68)

General Health Benefits and Pharmacological Activities of Triticum aestivum L.

Effect of Wheatgrass on Human Lymphocyte Cells

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