Hydrophobicity as a design criterion for polymer scaffolds in bone tissue engineering

Jansen, E.J.; Sladek, Raymond E.J.; Bahar, Hila; Yaffe, Avinoam; Gijbels, Marion J.J.; Kuijer, Roel; Bulstra, Sjoerd K.; Guldemond, Nick; Binderman, Itzhak; Koole, Léo H.

doi:10.1016/j.biomaterials.2004.11.011

Cited by 145 publications

(93 citation statements)

References 18 publications

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“…The choice for this biomaterial was based on our previous experience that these copolymers feature excellent biocompatibility, e.g., in contact with blood, ocular epithelium, and bone. 2,13,18,23 The coated mesh was compared in a series of experiments in vivo (using a rat model) with the uncoated Prolene Ò and coated Proceed Ò mesh (Ethicon, Johnson & Johnson, Somerville, NJ, USA). The latter is a three-layer composite of a PP mesh, an absorbable layer of oxidized regenerated cellulose, and an intermediate layer of polydioxanone.…”

Section: Introductionmentioning

confidence: 99%

Polypropylene Meshes to Prevent Abdominal Herniation. Can Stable Coatings Prevent Adhesions in the Long Term?

et al. 2008

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Abstract-Abdominal surgery is associated with a significant risk for incisional herniation. Hernia repair is routinely performed by implantation of synthetic meshes. Such meshes may cause serious adhesions between the implanted material and organs leading to intestinal obstruction or enterocutaneous fistulas. This study compares three knitted meshes for their capacity to prevent adhesion formation in an in vivo study. The meshes evaluated are polypropylene (Prolene Ò ), polypropylene coated with oxygenated regenerated cellulose-in principle-a biodegradable biomaterial (Proceed Ò ), and Prolene Ò coated with a nondegradable copolymer of the hydrophilic building block N-vinyl pyrrolidone (NVP) and the hydrophobic building block n-butylmethacrylate (BMA). The meshes were implanted in the abdomen of rats (followup 7 or 30 days). After 7 days, the formation of adhesions decreased in the order: Prolene Ò > NVP/BMA-coated Prolene Ò > Proceed Ò ; after 30 days, this order changed into: Proceed Ò > Prolene Ò > NVP/BMA-coated Prolene Ò . Both at 7 and at 30 days, Proceed Ò was the only mesh surrounded by macrophage cells that contained foreign materials, presumably degradation products of the (biodegradable) surface coating. The data indicate that long-term protection of implanted meshes against excessive adhesions may be achieved through stable biocompatible hydrogel surface coatings.

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Section: Introductionmentioning

confidence: 99%

Polypropylene Meshes to Prevent Abdominal Herniation. Can Stable Coatings Prevent Adhesions in the Long Term?

et al. 2008

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“…The osteoblastic cell sheets had inherent "rolling up" and contractile properties and, therefore, did not remain in functional sheet form without retention forces; even regular polystyrene dishes, which are considered to have high affinity for cells, were incapable of retaining the cell sheet for 24 h. Fortunately, most currently used titanium implant products are micro-roughened, similar to the acid-etched surface tested here, and the requirement for surface roughness may not be a signifi cant barrier in future applications. The impact of hydrophilicity or hydrophobicity of biomaterials on cellular attachment and retention remains contentious 28) , with biological outcomes differing depending upon the biomaterial type and surface morphology and the cell type [29][30][31] . With respect to titanium, hydrophilicity may positively aff ect the attachment and proliferation of osteoblasts under certain conditions, but there is no signifi cant correlation between the degree of hydrophilicity and cellular attachment 32,33) .…”

Section: Discussionmentioning

confidence: 99%

Titanium Delivery of Osteoblastic Cell Sheets: An <i>In Vitro</i> Study

Kanuru¹,

Sugita

Ikeda³

et al. 2018

J. Hard Tissue Biology.

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Abstract:We hypothesized that maximizing the number of cells on titanium implants would enhance its biological and bone-integration capabilities as a bone anchorage device. The purpose of this study was to determine the feasibility of fabricating osteoblastic cell sheets, combining them with titanium materials, and controlling their function. Rat femurderived bone marrow cells cultured on poly(N-isopropylacrylamide) (PIPAAm) dishes were harvested in sheet form by exploiting temperature-responsive hydrophobic to hydrophilic conversion of the dish and subsequently transferring them to titanium disks. Cell sheets remained adherent and spread on micro-roughened titanium surfaces but not on machined surfaces. The post-transfer alkaline phosphatase (ALP) activity of the cell sheets responded to the presence or absence of dexamethasone and was increased by pre-treatment with the osteogenic amino-acid derivative N-acetyl cysteine (NAC) in a dose-dependent manner. Double-layering cell sheets on titanium enhanced ALP activity twofold compared to single sheets. Titanium implants enfolded with autologous osteoblastic cell sheets showed 2.5-times stronger boneimplant integration than controls in a rat femur model. We show that micro-roughened titanium materials can be combined with osteoblastic cell sheets to improve cellular supply at the implant interface. Furthermore, cell sheet function can be controlled and enhanced by biologic agents and technical modifi cations.

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“…This 3D system supports cell-to-cell interaction, cell migration and division, and cell differentiation via two types of signals: physical and chemical 12,82 . Chemical cues include growth factors, biomolecules, or any type of functional groups that bind to cell membrane receptors to support cell proliferation or differentiation 12,83 . Physical cues, which are presumed to have a marked role in the differentiation of MSCs, are comprised of three subgroups: mechanical stimuli, electromagnetic, and topographical 12 .…”

Section: Mesenchymal Stem Cells and Physical Cues From The Ecmmentioning

confidence: 99%

The effect of nano-scale topography on osteogenic differentiation of mesenchymal stem cells

Faghihi

Eslaminejad²

2014

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. Large bone defects resulting from trauma or disease pose a threat to humans. Thus far, tissue engineering as an important clinical approach uses cells, growth factors and scaffolds to regenerate large areas of damaged bone tissue. Since bone is a nanocomposite structure, it is assumed that nanomaterial scaffolds can induce or promote osteogenesis by mimicking the cell niche at nano level. Methods and Results. In this review we highlighted the effect of nano-scale topography on osteogenic differentiation of Mesenchymal Stem Cells (MSCs) as potent cell candidates in bone engineered constructs. The key point in the induction of differentiation by nanomaterials is the discontinuity in their topography. This leads to alteration in protein adsorption and restriction of extracellular matrix deposition by the cells and consequently leads to changes in cell morphology and the frequency of accessible sites for cell adhesion. Here, we have reviewed the literature on the role of different types of nanomateial scaffolds in osteogenic differentiation of these cells. Since little is known about the underlying molecular networks induced by nanomaterials, we also reviewed possible underlying mechanisms of nanotopographical effects on the osteogenic differentiation of MSCs. Conclusions. Nano-scale materials provide a niche which is very similar to native bone in geometry and stiffness. Such nano-scale topographies improve the function of MSC-based engineered constructs in regeneration of bone defects.

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Hydrophobicity as a design criterion for polymer scaffolds in bone tissue engineering

Cited by 145 publications

References 18 publications

Polypropylene Meshes to Prevent Abdominal Herniation. Can Stable Coatings Prevent Adhesions in the Long Term?

Polypropylene Meshes to Prevent Abdominal Herniation. Can Stable Coatings Prevent Adhesions in the Long Term?

Titanium Delivery of Osteoblastic Cell Sheets: An <i>In Vitro</i> Study

The effect of nano-scale topography on osteogenic differentiation of mesenchymal stem cells

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