Hydrophobicity‐enhanced adhesion of novel biomimetic biocompatible polyaspartamide derivative glues

Abstract

The development of wet bioadhesives for tissue fixation and wound care remains a challenge. While various commercial bioadhesive products based on both natural and synthetic materials are available, both types of adhesive have several drawbacks including weak adhesion or toxicity. In this study, we present a novel mussel‐inspired synthetic adhesive based on polyaspartamide derivatives modified with dopamine and a series of hydrophobic n‐alkylamines (lauryl, octyl, hexyl and butyl), which shows very strong adhesion toward various types of substrates such as paper, glass and metals as well as several common plastics (0.1–0.6 MPa). Additionally, the effect of adding metal ions (Mg2+, Ca2+) as a coordination crosslinker to enhance adhesion performance was investigated using acryl plastic substrate. Even under deionized water conditions, the strong adhesion was found to be maintained for an appreciably long time after 24 h. This novel and biocompatible polymer glue system has potential in various applications including as a medical tissue adhesive and sealant. © 2018 Society of Chemical Industry

Polyaspartamide Functionalized Catechol-Based Hydrogels Embedded with Silver Nanoparticles for Antimicrobial Properties

“…The poor solubility, as hypothesized by Wang et al is due to strong intra- and intermolecular hydrogen-bonding interactions between the catechol moieties. This induces aggregation and chain entanglement, thus limiting solubility in water and most solvents [36]. The poor hydrophilicity could be interesting for drug delivery systems as the diffusion of drugs through the network is highly dependent on the water uptake [37].…”

Structurally Heterogeneous Amphiphilic Conetworks of Poly(vinyl imidazole) Derivatives with Potent Antimicrobial Properties and Cytocompatibility

“…The coated PDMS sheet was transparent, and the APCN strongly adhered on the PDMS surface owing to the hydrophobic interaction of dangling long-chain alkyl and PDMS surface. Presumably, a fraction of alkyl chains involve in the adhesion process on the PDMS surface, while the other alkyl groups are surface-segregated due to their low surface energy at the solid–air interface . The above-mentioned presumption is corroborated by the fact that the water contact angle on the different APCN-coated glass surfaces increased with increasing chain length of the alkyl groups in the conetworks (Figure S5, Supporting Information).…”

An Antifreezing/Antiheating Hydrogel Containing Catechol Derivative Urushiol for Strong Wet Adhesion to Various Substrates

“…Upon contact with a wet substrate, the benzene unit and flexible pendant hydrophobic alkyl chain expel water from the substrate surface, making catechol more easily interact with the chemical groups/atoms on substrate to form hydrogen bonding, hydrophobic association, and metal coordination (Figure ). In fact, the underwater adhesion of dopamine-based adhesives without the hydrophobic alkyl chain is poor …”

“…In fact, the underwater adhesion of dopamine-based adhesives without the hydrophobic alkyl chain is poor. 36 The repeated wet adhesion of PAAm-co-PUH (UH/AAm = 4%) hydrogel to glass and tinplate was further quantitatively examined. As shown in Figure S9a,b, the peak adhesion force moderately decreases with repeated underwater adhesion.…”