Hydrophobization of chitosan films by surface grafting with fluorinated polymer brushes

Lepoittevin, Bénédicte; Elzein, Tamara; Dragoé, Diana; Bejjani, Alice; Lemée, Frédéric; Levillain, Jocelyne; Bazin, Philippe; Roger, Philippe; Dez, Isabelle

doi:10.1016/j.carbpol.2018.10.044

Cited by 30 publications

(14 citation statements)

References 46 publications

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“…However, the conventional grafting techniques on chitosan do not give control on the side polymer chain lengths and composition, the number of grafting sites, and grafting percentage. Despite the great interest for conventional graft modification, controlled/living free radical polymerization techniques seem more attractive nowadays because they offer the possibility of synthesizing polymers with well-controlled structures under relatively simple experimental conditions [9,10].…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Graft-Poly(N-Isopropylacrylamide)/PVA Cryogels as Carriers for Mucosal Delivery of Voriconazole

et al. 2019

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The objective of this study was to prepare and characterize physically crosslinked gel formulations of chitosan (CS)-graft-poly(N-isopropyl acrylamide) (PNIPAAm) and polyvinyl alcohol (PVA) for smart delivery of an antifungal drug, Voriconazole, for mucosal applications. For this purpose, cryogels of CS-g-PNIPAAm/PVA and CS/PVA were tested by means of texture profile analysis and rheology to determine optimal matrix properties for topical application. The ratio of 75/25 v/v % CS-g-PNIPAAm/PVA was selected to be used for formulation since it gave low compressibility and hardness (1.2 and 0.6 N) as well as high adhesion properties and non-Newtonian flow behavior. The cryogels and formulations were further characterized by means of FTIR spectroscopy, swelling behavior, texture analysis, scanning electron microscopy (SEM), thermal (differential scanning calorimetry (DSC) and TGA), and rheological behavior. The drug loading capacity and in vitro release profile of the drug, storage stability, and cytotoxicity tests were also performed for the gel formulation. The FTIR, DSC, and TGA results verified the successful formation of cryogels. Swelling studies revealed a pH-dependent swelling ability with a maximum swelling degree of 1200% in acid and 990% in phosphate buffer (pH = 7.4). Thermal studies showed that CS-g-PNIPAAm/PVA 75/25 had higher thermal stability proving the structural complexity of the polymer. The loading capacity of Voriconazole was found to be 70% (w/w). The in vitro release profiles of Voriconazole showed Fickian release behavior for CS-g-PNIPAAm/PVA 75/25 gel with an approximate delivery of 38% within 8 h, slower than matrices containing unmodified chitosan. The storage stability test exhibited that the gel formulation was still stable even after aging for two months. Moreover, the cell culture assays revealed a non-toxic character of the polymeric matrix. Overall results showed that the CS-g-PNIPAAm/PVA 75/25 hydrogel has the potential to be used as a smart polymeric vehicle for topical applications.

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Section: Introductionmentioning

confidence: 99%

Chitosan-Graft-Poly(N-Isopropylacrylamide)/PVA Cryogels as Carriers for Mucosal Delivery of Voriconazole

et al. 2019

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“…In addition, bulk modification considerably affects the mechanical, optical, and barrier properties of the resulting materials [22]. Another modification approach is the grafting of modifiers onto the surface of the preformed chitosan material, which generally does not result in any changes in the material properties [23]. We have previously investigated the surface modification of chitosan films by low molecular weight aldehydes.…”

Section: Introductionmentioning

confidence: 99%

Lyophilic and Sorption Properties of Chitosan Aerogels Modified with Copolymers Based on Glycidyl Methacrylate and Alkyl Methacrylates

et al. 2022

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This paper discusses the influence of the structure of copolymers based on glycidyl methacrylate and alkyl methacrylates with C6–C18 hydrocarbon side groups on the wettability and sorption properties of surface-modified chitosan aerogels. The grafting of copolymers onto the surface of aerogels was confirmed by elemental analysis, X-ray photoelectron spectroscopy, and Fourier-transform infrared spectroscopy. As a result of the modification, with an increase in the amount of the hydrocarbon substituent alkyl methacrylate, the surface of the resulting materials became hydrophobic with contact angles in the range of 146–157°. At the same time, the water absorption of the aerogels decreased by a factor of 30 compared to that for unmodified aerogels, while the sorption capacity for light oil, diesel fuel, and synthetic motor oil remained at the level of more than 30 g/g. Chitosan aerogels with grafted copolymers based on glycidyl methacrylate and alkyl methacrylates retain biodegradation capacity; however, compared to unmodified chitosan, this process has an induction period.

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“…Most of the reported works on chitosan based biopolymer in ATRP and other RDRP techniques are done to load initiators on chitosan or to modify chitosan for application in other fields like pharmaceuticals, water treatment, biomedicine, etc. [41] [42]. However, with the use of a chitosan-metal coordination biopolymer, only a reducing agent is needed for the vinyl monomer polymerization to proceed, but the mechanism of polymerization has not been fully studied.…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Transition Metal Coordination Biopolymer: A Promising Heterogeneous Catalyst for Radical Ion Polymerization of Vinyl Acetate at Ambient Temperature.

Bisiriyu

Meijboom²

2021

Preprint

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The present study utilized chitosan obtained from crab shell and transition metal salts as precursors to synthesize chitosan-metal coordination biopolymers of Mn(II), Fe(III), Co(II) and Ni(II) [i.e Chit-Mn(II), Chit-Fe(III), Chit-Co(II) and Chit-NI(II) respectively]. The synthesized coordination biopolymers have been characterized using different instrumental techniques such as spectroscopic (UV-visible, FT-IR, XRD, EDS, and ICP-OES), thermal analysis (TGA and DTA), surface analysis (SEM), and hydrogen-temperature programmed reduction (H2-TPR) analysis. Spectroscopic studies confirmed the successful incorporation of the metals into the biopolymer matrix. Thermal analysis and H2-TPR revealed the reducibility of the Chit-Fe(III) at 120 ℃. While Chit-Fe(III) and Chit-Ni(II) were inactive, Chit-Co(II) and Chit-Mn(II) were found to be active towards vinyl acetate polymerization in the presence of aqueous Na2SO3. Furthermore, the polyvinyl acetate (PVAc) produced from Chit-Co(II) compared perfectly with a commercial PVAc and was in higher yield than PVAc produced from Chit-Mn(II). The polymerization has been shown to proceed via surface-initiated atom transfer radical polymerization (SI-ATRP), and the viscosity average molecular weight of PVAc produced has been measured as 25, 078. The density functional theory approach has been used to ascertain the coordination orientation of the Chit-Co(II) and explain its high efficiency towards vinyl acetate polymerization. The catalyst reusability test revealed an insignificant loss of activity for the Chit-Co(II) after seven cycles of polymerization. Kinetic studies show that the vinyl acetate polymerization suits the second-order kinetic model at ambient temperature. Thermodynamic studies also revealed that chain initiation is an endothermic process while chain propagation is an exothermic process. The result of this work also suggests an investigation of chitosan-metal coordination biopolymer via low-ppm ATRP approach for possible biomedical application.

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Hydrophobization of chitosan films by surface grafting with fluorinated polymer brushes

Cited by 30 publications

References 46 publications

Chitosan-Graft-Poly(N-Isopropylacrylamide)/PVA Cryogels as Carriers for Mucosal Delivery of Voriconazole

Chitosan-Graft-Poly(N-Isopropylacrylamide)/PVA Cryogels as Carriers for Mucosal Delivery of Voriconazole

Lyophilic and Sorption Properties of Chitosan Aerogels Modified with Copolymers Based on Glycidyl Methacrylate and Alkyl Methacrylates

Chitosan-Transition Metal Coordination Biopolymer: A Promising Heterogeneous Catalyst for Radical Ion Polymerization of Vinyl Acetate at Ambient Temperature.

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