Recently, metal‐organic frameworks (MOFs) have been effectively established as potential nanocarriers for the drug delivery. In this study, we have examined a novel framework containing TiO2@Chitosan@ZIF‐8 for the delivery of acyclovir (ACV). The structure elucidation and physicochemical characterization of the prepared nanocarrier were investigated by various spectroscopic techniques such as Fourier‐transform infrared spectroscopy (FT‐IR), ultraviolet‐visible spectroscopy (UV‐Vis), energy‐dispersive X‐ray spectroscopy (EDX), X‐ray diffraction (XRD), field emission scanning electron microscopy (FE‐SEM), brunauer‐emmett‐teller (BET), and thermal gravimetric analysis (TGA). The obtained results demonstrated that 90 % of the acyclovir was loaded on the TiO2@Chitosan@ZIF‐8 framework. The drug release study was performed in PBS (phosphate buffer saline, pH:7.4) and AB (acetate buffer, pH:5) solutions, which showed 78 % and 82 % release within 3 days.