Hydrotropic solubilization of nimesulide for parenteral administration

Agrawal, Shikha; Pancholi, Shyam S.; Jain, NK; Agrawal, G. P.

doi:10.1016/j.ijpharm.2004.01.012

Cited by 97 publications

(86 citation statements)

References 12 publications

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“…Solubility was determined in triplicate. [17][18][19][20] Figure 5]. Drug was estimated spectrophotometrically in mixed solvent system and distilled water to observe any interference between drug and excipients by taking respective reagents blank at appropriate wavelength during study.…”

Section: Solubility Determinationmentioning

confidence: 99%

“…The aseptic room was fumigated using a mixture of 40% formaldehyde and potassium permanganate and the UV lights were switched on for 30 min before formulation of injections and the filling of injections into vials. [17][18][19][20] …”

Section: Preparation Of Aseptic Areamentioning

confidence: 99%

“…Finally, the stoppers were rinsed with freshly prepared sterile distilled water and dried in vacuum oven under aseptic condition. [18][19][20] …”

Section: Treatment Of Packing Materialsmentioning

confidence: 99%

“…The solutions were analyzed spectrophotometrically at 274 nm for drug content after appropriate dilutions with distilled water using the same vehicle as blank after appropriate dilution. [17][18][19][20] Aseptic filtration and packaging…”

Section: Preparation Of Aqueous Injectionmentioning

confidence: 99%

“…Therefore, the authors have proposed a mixed-solvency approach for poorly water-soluble drugs. [17][18][19][20] In this research, aceclofenac was used as model drug (poorly water soluble drug), it is white crystalline powder, practically insoluble in water, freely soluble in acetone, soluble in ethanol (96%) [ Figure 1]. [21] The solubilization power of the cosolvents, two solid solubilizers, i.e., urea and sodium citrate system and mixed solvent system were evaluated.…”

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Solanki

2017

AJP

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Context: Water solubility is an important molecular property for successful drug development as it is a key factor governing drug access to biological membranes. The solubilization of poorly water soluble drug by facilitated mixed solvency is presented. Aim: The aim was to develop the injection formulations of the model poorly water-soluble drug. Settings and Design: Trial and error based experimental study. Materials and Methods: Mixed solvency approach was used to solubilize the hydrophobic drug. Mixed solvent system prepared using water-soluble hydrotropes (such as sodium citrate and urea) and water-miscible cosolvents, such as polyethylene glycol (PEG) 200, PEG 300, PEG 400, PEG 600, glycerin, propylene glycol, and ethanol. Drug was characterized using ultraviolet, Fourier Transform infrared (FT-IR), and Raman spectroscopy. Solubilizing power (Φ) and the Gibbs free energy of transfer (ΔG 0 tr) were determined. Various properties of solution such as pH, viscosity, specific gravity, and refractive index were also studied. Results: Desired solubility of drug achieved in a mixed solvent blend AF5, which was more than 200 fold as compared to the solubility in distilled water 0.152 mg/ml. Drug content was found to be more than 98%. FT-IR and Raman spectroscopy results may support intermolecular hydrogen bonding between drug and mixed solvent system. Developed formulation was physically and chemically stable. Conclusion: This technique proved a synergistic enhancement in solubility of a poorly water soluble drug due to mixed solvent effect and produces a stable formulation. Mixed solvency concept may reduce the individual concentration of solubilizers and so reduce their toxicity associated with them.

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Section: Solubility Determinationmentioning

confidence: 99%

Section: Preparation Of Aseptic Areamentioning

confidence: 99%

“…Finally, the stoppers were rinsed with freshly prepared sterile distilled water and dried in vacuum oven under aseptic condition. [18][19][20] …”

Section: Treatment Of Packing Materialsmentioning

confidence: 99%

Section: Preparation Of Aqueous Injectionmentioning

confidence: 99%

mentioning

confidence: 99%

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2017

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Synthesis, characterization, and thermal behaviors of tannin stearates prepared from quebracho and pine bark extracts

Luo

Grigsby

Edmonds

et al. 2010

J of Applied Polymer Sci

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Reported is the preparation of various condensed tannin stearates and the associated chemical characterization and thermal properties of these products. Stearate esters of condensed tannins from both quebracho and pine bark extracts were prepared in generally high, isolated yields from reaction with stearic acid chloride. Tannin esterification was confirmed by both Fourier transform infrared and nuclear magnetic resonance (NMR), and the average degree of stearate substitution was calculated from 1 H-NMR analysis. Product degree of substitution (DS) was observed to proportionately increase with higher stearic acid chloride ratio with maximum DS values of 4.0 and 5.1 achieved for quebracho and pine tannins, respectively. Thermal analysis revealed that tannin stearate products have increased thermal stability with a degradation onset at significantly higher temperature for those samples possessing relatively greater DS. Analysis using differential scanning calorimetry revealed isolated products to consist of multiple components which exhibit interesting melt behaviors, a likely result from their work up on isolation. However, multiple melt features of the individual components in products were lost on heating to give single, broad melt endotherms due to coalescence of sample components. Furthermore, tannin stearate samples with high DS show relatively greater endothermic melting at higher temperature than those samples with lower DS.

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Effective Separation of Petro Products through Hydrotropy

2008

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This paper presents a comprehensive study on the effect of hydrotropes such as sodium salicylate, sodium benzoate, and nicotinamide on the separation of a near boiling mixture, o-/p-xylene. The influence of a wide range of hydrotrope concentrations (0 to 3.0 mol/L) and different system temperatures (303 to 333 K) on the separation of o-/p-xylene were studied. All hydrotropes used in this work showed an enhancement in the percentage extraction of p-xylene to different degrees. The percentage extraction of p-xylene from the o-/p-xylene mixture increases with an increase in hydrotrope concentration and also with system temperature. A minimum hydrotrope concentration (MHC) was found essential to initiate significant extraction of p-xylene from the o-/p-xylene mixture. The maximum enhancement factor, which is the ratio of the value in the presence and absence of a hydrotrope, was determined for both cases. The Setschenow constant, k s , a measure of the effectiveness of a hydrotrope, was determined for each case.

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Hydrotropic solubilization of nimesulide for parenteral administration

Cited by 97 publications

References 12 publications

Untitled

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Synthesis, characterization, and thermal behaviors of tannin stearates prepared from quebracho and pine bark extracts

Effective Separation of Petro Products through Hydrotropy

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