Hydroxamic acid - A novel molecule for anticancer therapy

Abstract

Hydroxamic acid is a potent moiety not only in the field of cancer therapy but also as a mutagenic agent. Among the various derivatives of hydroxamic acid, SAHA (Suberoylanilide Hydroxamic Acid) is considered as a potent anticancer agent. Scientists from the different corner synthesized different hydroxamic acid moieties with some straight chain oxazole, thiadiazole, biphenyl moieties in the terminal position. Acetylation and deacetylation of histones of the core proteins of nucleosomes in chromatin play an important role in the regulation of gene expression. The level of acetylation of histones is established and maintained by two classes of enzymes, histone acetyltransferase and histone deacetylases, which have been identified as transcriptional coactivators and transcriptional corepressors, respectively. There is increasing evidence that aberrant histone acetylation has been linked to various malignant diseases. Great efforts are currently underway for the design of more potent and less toxic candidates for the treatment of cancer. In recent years, hydroxamic acid derivatives have attracted increasing attention for their potential as highly efficacious in combating various etiological factors associated with cancer. Our main intention to draw an attention is that this single functional moiety has not only fit in the receptor but also create a diversified activity.

Five Unprecedented Secondary Metabolites from the Spider Parasitic Fungus Akanthomyces novoguineensis

“…In order to evaluate the biological activity of Compounds 1 – 5 , they were tested for their antimicrobial, cytotoxic, anti-biofilm, and nematicidal activities, but none of them displayed any activity, even at the highest tested concentration of 300, 37, 33.33, and 100 μg/mL for those assays, respectively. Notably, Compound 4 did not possess any significant cytotoxicity against the tested human cervical carcinoma cell lines, although it has the same functional group as hydroxamic acid derivatives, which have been proposed by Pal and Saha [ 8 ] as powerful anticancer molecules. Moreover, it has also been found that pyrazine and a 2-naphthol bearing glucoside have lost the activity even though pyrazine and its analogues have been reported for decades to possess broad spectrum biological activities [ 9 , 10 , 11 , 12 ].…”

Structures of rhenium(I) complexes with 3-hydroxyflavone and benzhydroxamic acid as O,O′-bidentate ligands and confirmation of π-stacking by solid-state NMR spectroscopy

“…When coordinated to metal ions, promising results were obtained and some compounds show a range of biological activities (Zhou et al, 2001;Chen et al, 2009;Wang et al, 2006;Naso et al, 2010;Durgo et al, 2011;Pereira et al, 2007;Etcheverry et al, 2008;Ferrer et al, 2006). Hydroxamic acid and its derivatives coordinate to a wide variety of transition metal ions either as monoanionic hydroxamate or dianionic hydroximate O,O 0 -bidentate ligands and have also been of interest in applications in medicine (Codd, 2008;Sresutharsan et al, 2017;Adiguzel et al, 2017); it is considered by the research community as an important anticancer therapy candidate (Pal & Saha, 2012). One of the most significant uses of hydroxamic acids, however, is for the treatment of iron-overload disease and, due to some shortcomings of current drugs, much research is focused in this field (Kalinowski & Richardson, 2005;Chaston & Richardson, 2003;Li et al, 2004;Zheng et al, 1985;Tacke et al, 2000;Casellato et al, 1984).…”

Evaluation of the safety profile and antioxidant activity of fatty hydroxamic acid from underutilized seed oil of Cyperus esculentus

“…Although hydroxamic acid and a number of its derivatives have been synthesised from simple fine chemicals, they have been shown to be expensive and may have environmental concerns [13][14][15] . There have been little reports on the use of biomass 1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 as feed stock for the synthesis of hydroxamic acid.…”