Hydroxy acids of the seed oils of five plants of the family Asteraceae

Ul’chenko, N. T.; Gigienova, É. I.; Umarov, A. U.; Isamukhamedov, A. Sh.

doi:10.1007/bf00566427

Cited by 9 publications

(3 citation statements)

References 10 publications

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“…Ul’chenko [ 39 , 44 , 45 , 46 , 47 , 48 ] isolated fatty oil from 100 g of achenes by extraction with hexane at room temperature. Substances from the husks of cypselae were extracted by petroleum ether (40–60 °C).…”

Section: Chemical Compositionmentioning

confidence: 99%

Traditional Medicine Plant, Onopordum acanthium L. (Asteraceae): Chemical Composition and Pharmacological Research

Robertovna

Konovalov

Shamilov

et al. 2019

Plants

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For many years, plants have been used in the traditional medicine of different cultures. The biennial plant of the family Asteraceae, Onopordum acanthium L., also known as Scotch thistle, is used in traditional medicine as an anti-inflammatory, antitumor, and cardiotonic agent. The plant is widespread in the world; it grows in Europe and Asia and was introduced to America and Australia. Stems and buds of the first-year plant are used in cooking as an analogue of artichoke in European cuisine. Additionally, inflorescences contain a complex of proteolytic enzymes “onopordosin”, which may be used as a milk-clotting agent in the dairy industry. The chemical composition of the aerial part and roots of O. acanthium is represented by flavonoids, phenylpropanoids, lignans, triterpenoids, sesquiterpene lactones, and sterols. The anti-inflammatory, antiproliferative, and cardiotonic properties of the plant have been confirmed by pharmacological experiments with extracts and individual compounds using in silico, in vitro, and in vivo methods. This work is a review of information on the chemical composition and pharmacological studies of O. acanthium as a promising medicinal plant.

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Section: Chemical Compositionmentioning

confidence: 99%

Traditional Medicine Plant, Onopordum acanthium L. (Asteraceae): Chemical Composition and Pharmacological Research

Robertovna

Konovalov

Shamilov

et al. 2019

Plants

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“…The Asteraceae family is host to a number of species associated with the accumulation of unusual FAs (Badami and Patil 1980;Tsevegsüren et al 2003) including D12-epoxy (vernolic acid) (Cahoon et al 2002) and D12-acetylenic FAs (Lee et al 1998) through the activities of diiron fatty acid desaturases (Lee et al 1998). In addition, some Asteraceae members accumulate D12-hydroxylated FAs (Ul'chenko et al 1981). This metabolic diversity is interesting biochemically, because it again raises the question of selectivity (or conversely surmounting bottlenecks) for certain enzymatic steps.…”

Section: Future Directions For Fatty Acid Modification In Safflowermentioning

confidence: 99%

High level accumulation of gamma linolenic acid (C18:3Δ6.9,12 cis) in transgenic safflower (Carthamus tinctorius) seeds

Nykiforuk

Shewmaker²,

Harry

et al. 2011

Transgenic Res

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Gamma linolenic acid (GLA; C18:3Δ6,9,12 cis), also known as γ-Linolenic acid, is an important essential fatty acid precursor for the synthesis of very long chain polyunsaturated fatty acids and important pathways involved in human health. GLA is synthesized from linoleic acid (LA; C18:2Δ9,12 cis) by endoplasmic reticulum associated Δ6-desaturase activity. Currently sources of GLA are limited to a small number of plant species with poor agronomic properties, and therefore an economical and abundant commercial source of GLA in an existing crop is highly desirable. To this end, the seed oil of a high LA cultivated species of safflower (Carthamus tinctorius) was modified by transformation with Δ6-desaturase from Saprolegnia diclina resulting in levels exceeding 70% (v/v) of GLA. Levels around 50% (v/v) of GLA in seed oil was achieved when Δ12-/Δ6-desaturases from Mortierella alpina was over-expressed in safflower cultivars with either a high LA or high oleic (OA; C18:1Δ9 cis) background. The differences in the overall levels of GLA suggest the accumulation of the novel fatty acid was not limited by a lack of incorporation into the triacylgylcerol backbone (>66% GLA achieved), or correlated with gene dosage (GLA levels independent of gene copy number), but rather reflected the differences in Δ6-desaturase activity from the two sources. To date, these represent the highest accumulation levels of a newly introduced fatty acid in a transgenic crop. Events from these studies have been propagated and recently received FDA approval for commercialization as Sonova™400.

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“…[5,[9][10][11][12] and fatty acids from C. aurea C.Winkl., C. seversovii Regel, C. umbrosa Bunge. [13,14]. In a study, ethanol extracts from different Cousinia species were subjected to cytotoxic screening on the fibrocarcinoma cell line.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Secondary Metabolites in Two Cousinia species

Paşayeva

Fatullayev

Karakuş

et al. 2020

International Journal of Secondary Metabolite

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Cousinia is one of the widespread genera of Asteraceae family. According to previous studies on some Cousinia species it was found that these species are rich of triterpenes, sesquiterpenes, flavonoids, acetylenes and steroids. According to our knowledge, there are no published reports on the chemical composition of C. iconica Hub.-Mor. and C. aintabensis Boiss. & Hausskn., thus we aimed to investigate secondary metabolites of these species. In this study, the phytochemical constituents of these species were evaluated. Seven of identified compounds were quantified. The quantitative and qualitative determination of compounds within the extracts was carried out by LC-MS/MS. Phytochemical analyses revealed the presence of flavonoids, saponins, terpenes and steroids. Preliminary examination of the mass spectrums revealed the presence of phenolic acids and derivatives and flavonoid compounds in extracts. According to quantitative analyses the main compound of C. iconica (CI) and C. aintabensis (CA) extracts was rutin with the highest contents (169.779 µg/mgextract and 161.638 µg/mgextract). Moreover, qualitative and quantitative study combined with different biological activities will shed new lights to the advanced studies.

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Hydroxy acids of the seed oils of five plants of the family Asteraceae

Cited by 9 publications

References 10 publications

Traditional Medicine Plant, Onopordum acanthium L. (Asteraceae): Chemical Composition and Pharmacological Research

Traditional Medicine Plant, Onopordum acanthium L. (Asteraceae): Chemical Composition and Pharmacological Research

High level accumulation of gamma linolenic acid (C18:3Δ6.9,12 cis) in transgenic safflower (Carthamus tinctorius) seeds

Characterization of Secondary Metabolites in Two Cousinia species

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