Hydroxyapatite and calcium phophate coatings on aluminium oxide orbital implants

Jordan, David R.; Brownstein, Seymour; Gilberg, Steve; Coupal, Dustin; Kim, Sukyoung; Mawn, Louise A.

doi:10.1016/s0008-4182(02)80092-8

Cited by 20 publications

(14 citation statements)

References 21 publications

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“…Hydroxyapatite (HA) implants were advocated in the 1980s to replace volume in anophthalmic sockets and to improve motility of the external prosthesis, based on the idea that these implants could be integrated to the host tissues and be coupled to the external prosthesis, transmitting the extraocular muscle movements to the prosthesis [ 1 , 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Chronic Orbital Inflammation Associated to Hydroxyapatite Implants in Anophthalmic Sockets

Galindo‐Ferreiro

Elkhamary

Maktabi

et al. 2017

Case Rep Ophthalmol

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Purpose: We report 6 patients who received a hydroxyapatite (HA) orbital implant in the socket and developed chronic orbital inflammation unresponsive to conventional medical therapy. Case Reports: We assisted 6 cases (4 males, 2 females) who received an HA orbital implant in the socket between 2015 and 2016 at King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, and developed chronic orbital inflammation with chronic discharge, redness, and pain (onset from weeks to over 2 decades after surgery). Computed tomography evaluation indicated inflammation in the orbital tissues, and histological examination showed a foreign body granulomatous reaction mainly localized around and blanching the HA implant. The condition was unresponsive to usual medical treatment and was resolved immediately after implant removal. Conclusions: Chronic inflammation can occur decades after placement of an HA implant in the orbit and can be successfully treated with implant removal.

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Section: Introductionmentioning

confidence: 99%

Chronic Orbital Inflammation Associated to Hydroxyapatite Implants in Anophthalmic Sockets

Galindo‐Ferreiro

Elkhamary

Maktabi

et al. 2017

Case Rep Ophthalmol

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“…A bone-mineral-like CaP coating can be achieved on titanium surface by simply incubating the implants in modified simulated body fluid (m-SBF) at ambient conditions [16]. Many studies have demonstrated that the biomimetic CaP coating could actively promote bone ingrowth and improve implant-bone integration [17–21]. …”

Section: Introductionmentioning

confidence: 99%

Cellular Performance Comparison of Biomimetic Calcium Phosphate Coating and Alkaline-Treated Titanium Surface

Wei

2013

BioMed Research International

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The influence of biomimetic calcium phosphate coating on osteoblasts behavior in vitro is not well established yet. In this study, we investigated the behavior of osteoblastic rat osteosarcoma 17/2.8 cells (ROS17/2.8) on two groups of biomaterial surfaces: alkaline-treated titanium surface (ATT) and biomimetic calcium phosphate coated ATT (CaP). The cell attachment, proliferation, differentiation, and morphology on these surfaces were extensively evaluated to reveal the impact of substrate surface on osteoblastic cell responses. It was found that the ROS17/2.8 cells cultured on the ATT surface had higher attachment and proliferation rates compared to those on the CaP surface. Our results also showed that the calcium phosphate coatings generated in this work have an inhibiting effect on osteoblast adhesion and further influenced the proliferation and differentiation of osteoblast compared to the ATT surface in vitro. Cells on the ATT surface also exhibited a higher alkaline phosphatase activity than on the CaP surface after two weeks of culture. Immunofluorescence staining and scanning electron microscopy results showed that the cells adhered and spread faster on the ATT surface than on the CaP surface. These results collectively suggested that substrate surface properties directly influence cell adhesion on different biomaterials, which would result in further influence on the cell proliferation and differentiation.

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“…Besides, long-term follow up has demonstrated it to be economical and less biodegradable. 20 Jordan et al 21 reported that 12mm-diameter alumina sphere has more consistent pore size and weighs less than the HAp sphere of the same diameter. Magnetic resonance imaging, in vivo vascularization studies demonstrated enhancement of the implant to its center by 4 weeks after implantation in the rabbit.…”

Section: -14mentioning

confidence: 99%

Fibrovascularization of Intraorbital Hydroxyapatite-Coated Alumina Sphere in Rabbits

Chung

Song

Lee

et al. 2005

Korean J Ophthalmol

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We investigated the fibrovascular ingrowth and fibrovascular tissue maturation of hydroxyapatitecoated, porous alumina sphere (Alumina sphere) in comparison with the hydroxyapatite sphere (HAp sphere) in rabbits. Alumina spheres and HAp spheres were implanted in the left orbits of 42 New Zealand white rabbits after enucleation. Fibrovascular ingrowth and maturation were graded from 1 to 5 at postoperative 1, 2, 3, 4, 8, 12 and 24 weeks. We defined 4 phases: postoperative 1-2 weeks as phase I, 3-4 weeks as phase II, 8-12 weeks as phase III, and 24 weeks as phase IV. The grade was analyzed at each phases. There was no significant difference in fibrovascular ingrowth and maturation between the two groups at all 4 phases, except phase II at which the Alumina sphere showed significantly lower maturation grade (p<0.05). We concluded that the Alumina sphere is an ideal orbital implant material and an ideal substitute for the HAp sphere in clinical practice.

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Hydroxyapatite and calcium phophate coatings on aluminium oxide orbital implants

Cited by 20 publications

References 21 publications

Chronic Orbital Inflammation Associated to Hydroxyapatite Implants in Anophthalmic Sockets

Chronic Orbital Inflammation Associated to Hydroxyapatite Implants in Anophthalmic Sockets

Cellular Performance Comparison of Biomimetic Calcium Phosphate Coating and Alkaline-Treated Titanium Surface

Fibrovascularization of Intraorbital Hydroxyapatite-Coated Alumina Sphere in Rabbits

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