Hydroxyapatite/Calcium Carbonate (HA/CC) vs. Plaster of Paris: A Histomorphometric and Radiographic Study in a Rabbit Tibial Defect Model

Jamali, Amir A.; Hilpert, Andrea; Debes, Jack C.; Afshar, Philip; Rahban, Shahrad R.; Holmes, Ralph E.

doi:10.1007/s00223-001-1087-x

Cited by 57 publications

(48 citation statements)

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“…Namely, even the least sparingly soluble calcium-deficient apatites usually resorb slower than the new bone tissue formation rate [10], whereas HAP with high porosity is weak even to compression and not suitable for load-bearing applications [11]. An alternative approach has comprised admixing more resorbable calcium phosphates, typically tricalcium [12] or dicalcium [13] phosphates, or other calcium compounds, such as sulfates [14] or carbonates [15], to pure HAP.…”

Section: Introductionmentioning

confidence: 99%

Is there a relationship between solubility and resorbability of different calcium phosphate phases in vitro ?

Uskoković

2016

Biochimica et Biophysica Acta (BBA) - General Subjects

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BACKGROUND Does chemistry govern biology or it is the other way around - that is a broad connotation of the question that this study attempted to answer. METHOD Comparison was made between the solubility and osteoclastic resorbability of four fundamentally different monophasic CP powders with monodisperse particle size distributions: alkaline hydroxyapatite (HAP), acidic monetite (DCP), β-calcium pyrophosphate (CPP), and amorphous CP (ACP). RESULTS With the exception of CPP, the difference in solubility between different calcium phosphate (CP) phases became neither mitigated nor reversed, but augmented in the resorptive osteoclastic milieu. Thus, DCP, a phase with the highest solubility, was also resorbed more intensely than any other CP phase, whereas HAP, a phase with the lowest solubility, was resorbed least. CPP becomes retained inside the cells for the longest period of time, indicating hindered digestion of only this particular type of CP. Osteoclastogenesis was mildly hindered in the presence of HAP, ACP and DCP, but not in the presence of CPP. The most viable CP powder with respect to the mitochondrial succinic dehydrogenase activity was the one present in natural biological bone tissues: HAP. CONCLUSION Chemistry in this case does have a direct effect on biology. Biology neither overrides nor reverses the chemical propensities of inorganics with which it interacts, but rather augments and takes a direct advantage of them. SIGNIFICANCE These findings set the fundamental basis for designing the chemical makeup of CP and other biosoluble components of tissue engineering constructs for their most optimal resorption and tissue regeneration response.

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Section: Introductionmentioning

confidence: 99%

Is there a relationship between solubility and resorbability of different calcium phosphate phases in vitro ?

Uskoković

2016

Biochimica et Biophysica Acta (BBA) - General Subjects

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“…Fast-setting CaP bone cements have been studied in depth and developed in the last few years essentially as bone filling and bone reinforcement biomaterials due to their excellent biocompatibility and bioactivity. However, even though they can perfectly fill a bone cavity and be shaped as desired [2][3][4][5][6][7][8][9][10], one of the main concerns of surgeons is to reach higher rates of resorption, an improvement of bone reconstruction and to a lesser extent higher mechanical resistance [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Calcium carbonate–calcium phosphate mixed cement compositions for bone reconstruction

Combes

Bareille

Rey

2006

J Biomedical Materials Res

116

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The feasibility of making calcium carbonate-calcium phosphate (CaCO 3 -CaP) mixed cements, comprising at least 40 % (w/w) CaCO 3 in the dry powder ingredients, has been demonstrated.Several original cement compositions were obtained by mixing metastable crystalline calcium carbonate phases with metastable amorphous or crystalline calcium phosphate powders in aqueous medium. The cements set within at most 1 hour at 37°C in atmosphere saturated with water. The hardened cement is microporous and exhibits weak compressive strength. The setting reaction appeared to be essentially related to the formation of a highly carbonated nanocrystalline apatite phase by reaction of the mestastable CaP phase with part or almost all of the metastable CaCO 3 phase. The recrystallization of metastable CaP varieties led to a final cement consisting of a highly carbonated poorly crystalline apatite (PCA) analogous to bone mineral associated with various amounts of vaterite and/or aragonite. The presence of controlled amounts of CaCO 3 with a higher solubility than the apatite formed in the welldeveloped calcium phosphate cements might be of interest to increase resorption rates in biomedical cement and favor its replacement by bone tissue. Cytotoxicity testing revealed excellent cytocompatibility of CaCO 3 -CaP mixed cement compositions.

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“…Different animal species have also been used to evaluate bone substitutes. For instance, in vivo studies have been conducted in rats, 10,15,20 rabbits, 8,16,[21][22][23][24][25] dogs, 13,26,27 sheep, 9 and goats. 28 As these animals are different in terms of their metabolisms and bone physiology, direct and strict comparison between all these studies is difficult.…”

Section: Introductionmentioning

confidence: 99%

Small‐animal models for testing macroporous ceramic bone substitutes

et al. 2004

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The aim of this study was to compare the bone colonization of a macroporous biphasic calcium phosphate (MBCP) ceramic in different sites (femur, tibia, and calvaria) in two animal species (rats and rabbits). A critical size defect model was used in all cases with implantation for 21 days. Bone colonization in the empty and MBCP-filled defects was measured with the use of backscattered electron microscopy (BSEM). In the empty cavities, bone healing remained on the edges, and did not bridge the critical size defects. Bone growth was observed in all the implantation sites in rats (approx. 13.6 -36.6% of the total defect area, with ceramic ranging from 46.1 to 51.9%). The bone colonization appeared statistically higher in the femur of rabbits (48.5%) than in the tibia (12.6%) and calvaria (22.9%) sites. This slightly higher degree of bone healing was related to differences in the bone architecture of the implantation sites. Concerning the comparison between animal species, bone colonization appeared greater in rabbits than in rats for the femoral site (48.5% vs. 29.6%). For the other two sites (the tibia and calvaria), there was no statistically significant difference. The increased bone ingrowth observed in rabbit femurs might be due to the large bone surface area in contact with the MBCP ceramics. The femoral epiphysis of rabbits is therefore a favorable model for testing the bone-bonding capacity of materials, but a comparison with other implantation sites is subject to bias. This study shows that well-conducted and fully validated models with the use of small animals are essential in the development of new bone substitutes.

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Hydroxyapatite/Calcium Carbonate (HA/CC) vs. Plaster of Paris: A Histomorphometric and Radiographic Study in a Rabbit Tibial Defect Model

Cited by 57 publications

References 0 publications

Is there a relationship between solubility and resorbability of different calcium phosphate phases in vitro ?

Is there a relationship between solubility and resorbability of different calcium phosphate phases in vitro ?

Calcium carbonate–calcium phosphate mixed cement compositions for bone reconstruction

Small‐animal models for testing macroporous ceramic bone substitutes

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