Hydroxyapatite/Collagen Three-Dimensional Printed Scaffolds and Their Osteogenic Effects on Human Bone Marrow-Derived Mesenchymal Stem Cells

Li, Qing; Lei, Xiongxin; Wang, Xiaofei; Cai, Zhigang; Lyu, Peijun; Zhang, Guifeng

doi:10.1089/ten.tea.2018.0201

Cited by 58 publications

(28 citation statements)

References 7 publications

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“…HA/Col composites can serve not only as a scaffold for newly formed bone, but also as a carrier of drugs, delivering them directly to the bone [15]. What is more, the development of 3D printing techniques makes it possible to create implants for the patient's individual needs (printing scaffolds with a specific shape and porosity) [16,17].…”

Section: Introductionmentioning

confidence: 99%

Biologically Inspired Collagen/Apatite Composite Biomaterials for Potential Use in Bone Tissue Regeneration—A Review

2020

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Type I collagen and nanocrystalline-substituted hydroxyapatite are the major components of a natural composite—bone tissue. Both of these materials also play a significant role in orthopedic surgery and implantology; however, their separate uses are limited; apatite is quite fragile, while collagen’s mechanical strength is very poor. Therefore, in biomaterial engineering, a combination of collagen and hydroxyapatite is used, which provides good mechanical properties with high biocompatibility and osteoinduction. In addition, the porous structure of the composites enables their use not only as bone defect fillers, but also as a drug release system providing controlled release of drugs directly to the bone. This feature makes biomimetic collagen–apatite composites a subject of research in many scientific centers. The review focuses on summarizing studies on biological activity, tested in vitro and in vivo.

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Section: Introductionmentioning

confidence: 99%

Biologically Inspired Collagen/Apatite Composite Biomaterials for Potential Use in Bone Tissue Regeneration—A Review

2020

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“…There are certain materials whose properties are highly sensitive [23]. For example, resin [27], hydroxyl apatite (HAp) [28], chitosan-calcium phosphate [29], titanium [30], lithium iron [31] and so on. In the meantime, Zhang et al, [32] pointed out that materials have an overbearing infl uence that affects the adoption of 3D printing technology.…”

Section: Management and Organisationmentioning

confidence: 99%

An overview of critical success factors for implementing 3D printing technology in manufacturing firms

Shahrubudin¹,

Lee²,

Ramlan³

2019

J Appl Eng Science

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Additive manufacturing, also known as 3D printing or digital fabrication technology, is a process of accumulating deposited layers to form solid 3D objects from 3D models in digital fi les. 3D printing technology is a fast-emerging technology. Nowadays, 3D printing technology is successfully applied in shaping the globe and producing most of the products used today, from simple plastics to advanced ceramics and metallics. 3D printing technology can print an object layer by layer, by directly depositing the material using computer software, with only just one click. This paper gives an overview of the Critical Success Factors (CSFs) for 3D printing technology in manufacturing fi rms.The literature found in this paper is mainly from Emerald Insight, Science Direct, Google Scholar and Additive Manufacturing. Briefl y, the list of Critical Success Factors can be divided into nine major factors, which are cost, technology, business and support, management and organisation, materials, quality and accuracy, demand, the environment and lastly, research and development.

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“…The possibility to control porosity and interconnectivity provides a valuable tool to enhance cell-biomaterial or tissue-specific interactions, including the access and distribution of cells into the scaffold core, and to improve the transportation of nutrients and oxygen [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. Currently, the main strategies in bone tissue engineering are focused on the development of 3D printed scaffolds based on biomimetic composites, with high precision and reproducibility [ 3 , 6 , 8 , 9 , 10 , 11 ]. The extracellular matrix (ECM) of bone is a natural composite consisting of hydroxyapatite (inorganic phase) and type I collagen (main organic component) [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…The extracellular matrix (ECM) of bone is a natural composite consisting of hydroxyapatite (inorganic phase) and type I collagen (main organic component) [ 10 , 11 , 12 ]. The development of ceramic/polymer composites is a well known approach to imitate the natural bone tissue [ 9 , 11 , 12 , 13 ]. The organic component of such composites was often based on hydrogel materials since they replicate the structural and functional properties of native ECM [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…The main combination of biomaterials for composite scaffolds fabrication as bone tissue mimics was based on calcium phosphates as an inorganic component and hydrogels precursors as organic phase [ 3 , 12 , 17 ]. Hydroxyapatite, β-tricalcium phosphate or a combination of them, were broadly used to produce 3D printed composites due to their intrinsic bioactivity and osteoconductivity [ 2 , 3 , 6 , 8 , 9 , 10 , 12 , 17 , 22 , 24 ]. Apart from those, calcium silicates are another important bioceramic class which have gained considerable attention due to their outstanding bioactivity for biomimetic surface mineralization [ 22 , 23 , 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Development of 3D Bioactive Scaffolds through 3D Printing Using Wollastonite–Gelatin Inks

et al. 2020

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The bioactivity of scaffolds represents a key property to facilitate the bone repair after orthopedic trauma. This study reports the development of biomimetic paste-type inks based on wollastonite (CS) and fish gelatin (FG) in a mass ratio similar to natural bone, as an appealing strategy to promote the mineralization during scaffold incubation in simulated body fluid (SBF). High-resolution 3D scaffolds were fabricated through 3D printing, and the homogeneous distribution of CS in the protein matrix was revealed by scanning electron microscopy/energy-dispersive X-ray diffraction analysis (SEM/EDX) micrographs. The bioactivity of the scaffold was suggested by an outstanding mineralization capacity revealed by the apatite layers deposited on the scaffold surface after immersion in SBF. The biocompatibility was demonstrated by cell proliferation established by MTT assay and fluorescence microscopy images and confirmed by SEM micrographs illustrating cell spreading. This work highlights the potential of the bicomponent inks to fabricate 3D bioactive scaffolds and predicts the osteogenic properties for bone regeneration applications.

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Hydroxyapatite/Collagen Three-Dimensional Printed Scaffolds and Their Osteogenic Effects on Human Bone Marrow-Derived Mesenchymal Stem Cells

Cited by 58 publications

References 7 publications

Biologically Inspired Collagen/Apatite Composite Biomaterials for Potential Use in Bone Tissue Regeneration—A Review

Biologically Inspired Collagen/Apatite Composite Biomaterials for Potential Use in Bone Tissue Regeneration—A Review

An overview of critical success factors for implementing 3D printing technology in manufacturing firms

Development of 3D Bioactive Scaffolds through 3D Printing Using Wollastonite–Gelatin Inks

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