Hydroxyapatite for Biomedical Applications: A Short Overview

Fiume, Elisa; Magnaterra, Giulia; Rahdar, Abbas; Verné, Enrica; Baino, Francesco

doi:10.3390/ceramics4040039

Cited by 149 publications

(87 citation statements)

References 78 publications

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“…Nanomedicine has led to the development of a variety of nanoscale therapeutics and diagnostics to treat a variety of diseases, specifically cancer [6,14,15,17,18,[36][37][38][39][40][41][42][43][44][45][46]. This fact is broadly exploited in the field of DNA nanotechnology [47].…”

Section: Rna Nanotechnology For Diagnosis Of Cancersmentioning

confidence: 99%

Novel Perspectives towards RNA-Based Nano-Theranostic Approaches for Cancer Management

et al. 2021

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In the fight against cancer, early diagnosis is critical for effective treatment. Traditional cancer diagnostic technologies, on the other hand, have limitations that make early detection difficult. Therefore, multi-functionalized nanoparticles (NPs) and nano-biosensors have revolutionized the era of cancer diagnosis and treatment for targeted action via attaching specified and biocompatible ligands to target the tissues, which are highly over-expressed in certain types of cancers. Advancements in multi-functionalized NPs can be achieved via modifying molecular genetics to develop personalized and targeted treatments based on RNA interference. Modification in RNA therapies utilized small RNA subunits in the form of small interfering RNAs (siRNA) for overexpressing the specific genes of, most commonly, breast, colon, gastric, cervical, and hepatocellular cancer. RNA-conjugated nanomaterials appear to be the gold standard for preventing various malignant tumors through focused diagnosis and delivering to a specific tissue, resulting in cancer cells going into programmed death. The latest advances in RNA nanotechnology applications for cancer diagnosis and treatment are summarized in this review.

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Section: Rna Nanotechnology For Diagnosis Of Cancersmentioning

confidence: 99%

Novel Perspectives towards RNA-Based Nano-Theranostic Approaches for Cancer Management

et al. 2021

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“…Hydroxyapatite (HAP, Ca 10 (PO 4 ) 6 (OH) 2 ) is the thermodynamically most stable calcium phosphate (CaP) phase and is often considered the most similar among different CaPs to the mineral component of vertebrate's hard tissues [1]. In addition, HAP has excellent cytocompatibility and osteoconductivity, making it one of the most investigated materials in bone tissue engineering [2][3][4]. However, the mineral component of hard tissues, so-called biological apatite, is non-stoichiometric, poorly crystalline, ion-substituted hydroxyapatite [1,2,5].…”

Section: Introductionmentioning

confidence: 99%

A Comparative EPR Study of Non-Substituted and Mg-Substituted Hydroxyapatite Behaviour in Model Media and during Accelerated Ageing

et al. 2022

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To assess the application potential of novel biomaterials, their behaviour in model media and upon sterilization should be investigated, as well as the stability related to their storage conditions. Such data are lacking for Mg-substituted HAP (Mg-HAP). Therefore, the changes in the local structure of non-substituted and Mg-HAP after irradiation and immersion in corrected simulated fluid and saline solution for 28 days were followed by electron paramagnetic resonance (EPR) spectroscopy for the first time. To better understand the stability of radical species induced by sterilization, EPR spectra of samples kept for 2 h at temperatures up to 373 K were recorded to provide an insight into the stability of the sample storage conditions by the accelerated aging method. Samples were characterized by PXRD, FTIR, SEM, EDS, AAS and TGA. Results confirmed that irradiation does not induce changes in the composition or the structure of any of the investigated materials. Fading or the complete disappearance of radical signals in the EPR spectra after immersion in both media was accompanied by the disappearance of other phases formed as a minor byproduct in the synthesis of substituted HAP, as confirmed by PXRD and FTIR analysis. Obtained results confirm the great potential of Mg-HAPs for biomedical applications, although closer attention should be given to the processes related to sample storage stability at different temperatures.

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“…Moreover, the different forms of HA scaffold that are actively being used include granules ( Dorozhkin, 2015 ), paste and cement ( Ben-Nissan, 2014 ), coatings ( Eliaz & Metoki, 2017 ), porous ( Al-Naib, 2018 ), and dense blocks ( Megat Wahab et al, 2020 ). Nonetheless, concerns have been raised regarding the brittleness and limited degradation properties of HA, including the slow degradation rate ( Fiume et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Comparison between hydroxyapatite and polycaprolactone in inducing osteogenic differentiation and augmenting maxillary bone regeneration in rats

Luchman

Wahab

Ariffin

et al. 2022

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Background The selection of appropriate scaffold plays an important role in ensuring the success of bone regeneration. The use of scaffolds with different materials and their effect on the osteogenic performance of cells is not well studied and this can affect the selection of suitable scaffolds for transplantation. Hence, this study aimed to investigate the comparative ability of two different synthetic scaffolds, mainly hydroxyapatite (HA) and polycaprolactone (PCL) scaffolds in promoting in vitro and in vivo bone regeneration. Method In vitro cell viability, morphology, and alkaline phosphatase (ALP) activity of MC3T3-E1 cells on HA and PCL scaffolds were determined in comparison to the accepted model outlined for two-dimensional systems. An in vivo study involving the transplantation of MC3T3-E1 cells with scaffolds into an artificial bone defect of 4 mm length and 1.5 mm depth in the rat’s left maxilla was conducted. Three-dimensional analysis using micro-computed tomography (micro-CT), hematoxylin and eosin (H&E), and immunohistochemistry analyses evaluation were performed after six weeks of transplantation. Results MC3T3-E1 cells on the HA scaffold showed the highest cell viability. The cell viability on both scaffolds decreased after 14 days of culture, which reflects the dominant occurrence of osteoblast differentiation. An early sign of osteoblast differentiation can be detected on the PCL scaffold. However, cells on the HA scaffold showed more prominent results with intense mineralized nodules and significantly (p < 0.05) high levels of ALP activity with prolonged osteoblast induction. Micro-CT and H&E analyses confirmed the in vitro results with bone formation were significantly (p < 0.05) greater in HA scaffold and was supported by IHC analysis which confirmed stronger expression of osteogenic markers ALP and osteocalcin. Conclusion Different scaffold materials of HA and PCL might have influenced the bone regeneration ability of MC3T3-E1. Regardless, in vitro and in vivo bone regeneration was better in the HA scaffold which indicates its great potential for application in bone regeneration.

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Hydroxyapatite for Biomedical Applications: A Short Overview

Cited by 149 publications

References 78 publications

Novel Perspectives towards RNA-Based Nano-Theranostic Approaches for Cancer Management

Novel Perspectives towards RNA-Based Nano-Theranostic Approaches for Cancer Management

A Comparative EPR Study of Non-Substituted and Mg-Substituted Hydroxyapatite Behaviour in Model Media and during Accelerated Ageing

Comparison between hydroxyapatite and polycaprolactone in inducing osteogenic differentiation and augmenting maxillary bone regeneration in rats

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