Hydroxyapatite for Biomedicine and Drug Delivery

Biodegradable natural polymers have been investigated extensively as the best choice for encapsulation and delivery of drugs. The research has attracted remarkable attention in the pharmaceutical industry. The shortcomings of conventional dosage systems, along with modified and targeted drug delivery methods, are addressed by using polymers with improved bioavailability, biocompatibility, and lower toxicity. Therefore, nanomedicines are now considered to be an innovative type of medication. This review critically examines the use of natural biodegradable polymers and their drug delivery systems for local or targeted and controlled/sustained drug release against fatal diseases.

show abstract

“…Shows the advantages, disadvantages, biomedical applications, and methods of preparation for hydroxyapatite[120].…”

mentioning

confidence: 99%

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The rough surface of HAP, presence of hydroxyl group, and combined with the presence of two different charge planes on their surface, C-sites, and Psites, promote the adsorption of proteins to HAP [208]. Furthermore, the high surface to volume ratio properties of HAP nanoparticles, similar to any nanoparticle, made HAP suitable for loading and delivery of various drugs such as growth factors, hormones, antibiotics, and anticancer drugs [209]. Antibacterial properties of HAP nanocomposites as shown in Fig.…”

Section: Drug/gene/protein Carriersmentioning

confidence: 99%

Recent advances in natural polymer-based hydroxyapatite scaffolds: Properties and applications

Lett

Sagadevan

Fatimah

et al. 2021

European Polymer Journal

101

View full text Add to dashboard Cite

show abstract

“…By virtue of this, nHA allows a more efficient internalization and provides greater surface area for the adsorption of cells, drugs or other bioactive molecules [ 17 ]. Several reviews have outlined the application of nHA for the delivery of drugs and/or other bioactive molecules, i.e., growth factors, antibiotics, and chemotherapeutic drugs [ 18 , 19 ]. However, to the best of our knowledge, the application of nHA alone or as a delivery system to promote bone regeneration in vivo has not been systematically reviewed to date.…”

Section: Introductionmentioning

confidence: 99%

Nano-Hydroxyapatite as a Delivery System for Promoting Bone Regeneration In Vivo: A Systematic Review

Zaffarin

et al. 2021

Nanomaterials

View full text Add to dashboard Cite

Nano-hydroxyapatite (nHA) has been widely used as an orthopedic biomaterial and vehicle for drug delivery owing to its chemical and structural similarity to bone minerals. Several studies have demonstrated that nHA based biomaterials have a potential effect for bone regeneration with very minimal to no toxicity or inflammatory response. This systematic review aims to provide an appraisal of the effectiveness of nHA as a delivery system for bone regeneration and whether the conjugation of proteins, antibiotics, or other bioactive molecules to the nHA further enhances osteogenesis in vivo. Out of 282 articles obtained from the literature search, only 14 articles met the inclusion criteria for this review. These studies showed that nHA was able to induce bone regeneration in various animal models with large or critical-sized bone defects, open fracture, or methicillin-resistant Staphylococcus aureus (MRSA)-induced osteomyelitis. The conjugations of drugs or bioactive molecules such as bone-morphogenetic protein-2 (BMP-2), vancomycin, calcitriol, dexamethasone, and cisplatin were able to enhance the osteogenic property of nHA. Thus, nHA is a promising delivery system for a variety of compounds in promoting bone regeneration in vivo.

show abstract

Hydroxyapatite for Biomedicine and Drug Delivery

Cited by 24 publications

References 194 publications

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

Recent advances in natural polymer-based hydroxyapatite scaffolds: Properties and applications

Nano-Hydroxyapatite as a Delivery System for Promoting Bone Regeneration In Vivo: A Systematic Review

Contact Info

Product

Resources

About