Recent advances in natural polymer-based hydroxyapatite scaffolds: Properties and applications

Lett, J. Anita; Sagadevan, Suresh; Fatimah, Is; Hoque, Enamul; Lokanathan, Yogeswaran; Léonard, Estelle; Alshahateet, Solhe F.; Schirhagl, Romana; Oh, Won Chun

doi:10.1016/j.eurpolymj.2021.110360

Cited by 100 publications

(40 citation statements)

References 200 publications

(198 reference statements)

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“…Hitherto, although numerous biomaterials which are suitable for bone tissue engineering (particularly for regeneration and repair of bone defects) have been reported but calcium hydroxyapatite (Hap) commonly known as apatite occupied the top grade position. [4][5][6][7][8][9] Its outstanding compositional and structural resemblance with the apatitic phase of bone has appended it as the most preferable biomaterial. 4,[10][11][12] However, it is well established that crystallinity of Hap sets a restriction to its dissolution characteristics and thus relaxed mode degradation of crystalline Hap fails to comply with the growth rate of newly formed bone in vivo.…”

Section: Introductionmentioning

confidence: 99%

Exploring the biomedical competency of gamma-radiation aided hydroxyapatite and its composite fabricated with nano-cellulose and chitosan

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Exploring the biomedical competency of gamma-radiation aided hydroxyapatite and its composite fabricated with nano-cellulose and chitosan

et al. 2023

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“…Methods for compositing HANPs into a polymer matrix for processing include electrospinning, three-dimensional (3D) printing, freeze drying, etc. These hybrid composites can be formed into desired morphologies of braided thread, thin film, nanofiber composed membranes, scaffolds, microspheres or nano-beads, and sprayed coatings to enhance mechanical properties and adapt to target applications [ 47 , 48 ]. In addition to binding HANPs, these composites can be loaded with drugs, magnetic quantum dots, or grafted with growth factors or proteins according to different clinical needs.…”

Section: Introductionmentioning

confidence: 99%

Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review

et al. 2022

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Hydroxyapatite (HA), especially in the form of HA nanoparticles (HANPs), has excellent bioactivity, biodegradability, and osteoconductivity and therefore has been widely used as a template or additives for drug delivery in clinical applications, such as dentistry and orthopedic repair. Due to the atomically anisotropic distribution on the preferred growth of HA crystals, especially the nanoscale rod-/whisker-like morphology, HA can generally be a good candidate for carrying a variety of substances. HA is biocompatible and suitable for medical applications, but most drugs carried by HANPs have an initial burst release. In the adsorption mechanism of HA as a carrier, specific surface area, pore size, and porosity are important factors that mainly affect the adsorption and release amounts. At present, many studies have developed HA as a drug carrier with targeted effect, porous structure, and high porosity. This review mainly discusses the influence of HA structures as a carrier on the adsorption and release of active molecules. It then focuses on the benefits and effects of different types of polymer-HA composites to re-examine the proteins/drugs carry and release behavior and related potential clinical applications. This literature survey can be divided into three main parts: 1. interaction and adsorption mechanism of HA and drugs; 2. advantages and application fields of HA/organic composites; 3. loading and drug release behavior of multifunctional HA composites in different environments. This work also presents the latest development and future prospects of HA as a drug carrier.

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“…Hydroxyapatite [HA; Ca 10 (OH) 2 (PO 4 ) 6 ], which has been widely studied as a bone substitute in recent years, is similar to the main component of natural bone apatite. − HA has been used in various medical applications because of its mechanical stability, high activity, and good biocompatibility . However, the application of pure HAs is greatly limited to small or unloaded implants because of their low strength and fracture toughness .…”

Section: Introductionmentioning

confidence: 99%

Potential Load-Bearing Bone Substitution Material: Carbon-Fiber-Reinforced Magnesium-Doped Hydroxyapatite Composites with Excellent Mechanical Performance and Tailored Biological Properties

Zhao

Yang

Liu

et al. 2022

ACS Biomater. Sci. Eng.

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A potential load-bearing bone substitution and repair material, that is, carbon fiber (CF)-reinforced magnesium-doped hydroxyapatite (CF/Mg-HAs) composites with excellent mechanical performance and tailored biological properties, was constructed via the hydrothermal method and spark plasma sintering. A high-resolution transmission electron microscopy (TEM) was employed to characterize the nanostructure of magnesium-doped hydroxyapatite (Mg-HA). TEM images showed that the doping of Mg-induced distortions and dislocations in the hydroxyapatite lattice, resulting in decreased crystallinity and enhanced dissolution. Compressive strengths of 10% magnesium-doped hydroxyapatite (1Mg-HAs) and CF-reinforced 1Mg-HAs (CF/1Mg-HAs) were within the range of that of cortical bone. Compared with 1Mg-HAs, the fracture toughness of CF/1Mg-HAs increased by approximately 38%. The bioactivity, biocompatibility, and osteogenic induction properties of Mg-HAs and CF/Mg-HAs composites were evaluated in vitro using simulated body fluid (SBF) immersion, cell culture, osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and expression of genes associated with osteogenesis. When Mg-HAs were immersed in SBF, Mg2+ continued to release for up to 21 days. Mg-HAs demonstrated a satisfactory ability to induce apatite formation in comparison with HAs. The cell proliferation and morphology on CF/1Mg-HAs were similar to those of 1Mg-HAs, suggesting that adding CF had no adverse effect on cellular activity. The expression levels of osteogenesis-related genes [osteocalcin (OPN), osteopontin (OCN), and runt-related transcription factor 2 (Runx2)] on 1Mg-HAs were significantly higher at days 3 and 7 than those on HAs and 0.5Mg-HAs groups. This finding suggests that a certain amount of Mg doping had beneficial influences in the different stages of osteogenic differentiation and could induce osteogenic differentiation of BMSCs. The new bone volume to total volume ratio of implanted 1Mg-HAs (30.9% ± 4.1%) and CF/1Mg-HAs (25.4% ± 5.4%) was remarkably higher than that of HAs (21.6% ± 3.9%). 1Mg-HAs and CF/1Mg-HAs tailored an ideal effect of new bone information and implant osseointegration. The excellent mechanical performance and tailored biological properties of CF/Mg-HAs were attributed to nano Mg-doped HA, CF reinforcing, refined microstructure, and controlled composition.

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Recent advances in natural polymer-based hydroxyapatite scaffolds: Properties and applications

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Cited by 100 publications

References 200 publications

Exploring the biomedical competency of gamma-radiation aided hydroxyapatite and its composite fabricated with nano-cellulose and chitosan

Exploring the biomedical competency of gamma-radiation aided hydroxyapatite and its composite fabricated with nano-cellulose and chitosan

Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review

Potential Load-Bearing Bone Substitution Material: Carbon-Fiber-Reinforced Magnesium-Doped Hydroxyapatite Composites with Excellent Mechanical Performance and Tailored Biological Properties

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