Hydroxyapatite/gelatin/gellan sponges as nanocomposite scaffolds for bone reconstruction

Barbani, Niccoletta; Guerra, Giulio D.; Cristallini, Caterina; Urciuoli, Patrizia; Avvisati, Riccardo; Sala, Alessandro; Rosellini, Elisabetta

doi:10.1007/s10856-011-4505-2

Cited by 49 publications

(29 citation statements)

References 23 publications

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“…Blending GG with other types of biomolecules (e.g. 40 polysaccharides and enyzmes) for TE applications have also been considered [75][76][77][78][79][80][81] .…”

Section: Gellan Gum In Tissue Engineeringmentioning

confidence: 99%

Modified gellan gum hydrogels for tissue engineering applications

et al. 2013

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Gellan gum is an anionic linear polysaccharide well known for its use as a multi-functional gelling, stabilising and suspending agent in a variety of foods and personal care products. In this Highlight, we explore the recently established directions for gellan gum hydrogels as materials for applications in tissue engineering. We highlight that modified gellan gum will be well suited for this purpose, providing that a number of remaining challenges are addressed. Gellan gum is an anionic linear polysaccharide well known for its use as a multi-functional gelling, 5 stabilising and suspending agent in a variety of foods and personal care products. In this Highlight, we explore the recently established directions for gellan gum hydrogels as materials for applications in tissue engineering. We highlight that modified gellan gum will be well suited for this purpose, providing that a number of remaining challenges are addressed.

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“…Blending GG with other types of biomolecules (e.g. 40 polysaccharides and enyzmes) for TE applications have also been considered [75][76][77][78][79][80][81] .…”

Section: Gellan Gum In Tissue Engineeringmentioning

confidence: 99%

Modified gellan gum hydrogels for tissue engineering applications

et al. 2013

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“…As a result, scaffolds incorporated with HA provide a more favorable environment through increased adsorption of serum adhesion protein such as fibronectin and vitronectin [16]. Enhanced cellular responses have also been observed with the addition of other minerals (β-tricalcium phosphate, Dicalcium Phosphate Dihydrate), polymers (gellan, poly-lactide-co-glycolide) and proteins (bone morphogenetic protein, Wnt1 inducible signaling pathway protein) in combination with HA [17,18,19]. …”

Section: Introductionmentioning

confidence: 99%

A Preliminary Evaluation of Lyophilized Gelatin Sponges, Enhanced with Platelet-Rich Plasma, Hydroxyapatite and Chitin Whiskers for Bone Regeneration

Rodriguez

Sell

McCool

et al. 2013

Cells

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The purpose of this study was to perform a number of preliminary in vitro evaluations on an array of modified gelatin gel sponge scaffolds for use in a bone graft application. The gelatin gels were modified through the addition of a number of components which each possess unique properties conducive to the creation and regeneration of bone: a preparation rich in growth factors (PRGF, a bioactive, lyophilized form of platelet-rich plasma), hydroxyapatite, and chitin whiskers. Platelet-rich plasma therapy is an emerging practice that has proven effective in a number of clinical applications, including enhancing bone repair through improved deposition of new bony matrix and angiogenesis. As such, the inclusion of PRGF in our gelatin scaffolds was intended to significantly enhance scaffold bioactivity, while the addition of hydroxyapatite and chitin whiskers were anticipated to increase scaffold strength. Additionally, the gelatin sponges, which readily dissolve in aqueous solutions, were subjected to 1-Ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC) cross-linking, either during or post-gelation, to control their rate of degradation. Scaffolds were evaluated in vitro with respect to compressive strength, mass loss/degradation, protein release, and cellular interaction, with results demonstrating the potential of the gelatin gel sponge scaffold for use in the regeneration of bone.

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“…The mechanical properties of the Gel-nHA scaffolds were enhanced by incorporating polycaprolactone (PCL) [44] and gellan gum [45]. The former helped in the increase of the elastic modulus of the scaffold but increasing PCL concentration led to a decrease in the ultimate strain.…”

Section: Gelatin Based Compositesmentioning

confidence: 99%