Hydroxycitric acid delays intestinal glucose absorption in rats

Abstract

In this study, we investigated in rats if hydroxycitric acid (HCA) reduces the postprandial glucose response by affecting gastric emptying or intestinal glucose absorption. We compared the effect of regulator HCA (310 mg/kg) and vehicle (control) on the glucose response after an intragastric or intraduodenal glucose load to investigate the role of altered gastric emptying. Steele's one-compartment model was used to investigate the effect of HCA on systemic glucose appearance after an intraduodenal glucose load, using [U-(13)C]-labeled glucose and d-[6,6-(2)H(2)]-labeled glucose. Because an effect on postabsorptive glucose clearance could not be excluded, the effect of HCA on the appearance of enterally administered glucose in small intestinal tissue, liver, and portal and systemic circulation was determined by [U-(14)C]glucose infusion. Data show that HCA treatment delays the intestinal absorption of enterally administered glucose at the level of the small intestinal mucosa in rats. HCA strongly attenuated postprandial blood glucose levels after both intragastric (P < 0.01) and intraduodenal (P < 0.001) glucose administration, excluding a major effect of HCA on gastric emptying. HCA delayed the systemic appearance of exogenous glucose but did not affect the total fraction of glucose absorbed over the study period of 150 min. HCA treatment decreased concentrations of [U-(14)C]glucose in small intestinal tissue at 15 min after [U-(14)C]glucose administration (P < 0.05), in accordance with the concept that HCA delays the enteral absorption of glucose. These data support a possible role for HCA as food supplement in lowering postprandial glucose profiles.

Olanzapine causes hypothermia, inactivity, a deranged feeding pattern and weight gain in female Wistar rats

“…A silicon catheter (1.40-mm OD, 0.80-mm ID) was inserted through the gastric wall at the level of the corpus, extending 0.5 cm into the gastric lumen. The catheter was drawn subcutaneous towards the head where it was fixed to the skull with dental cement (Wielinga et al, 2005). Animals were given 0.1 ml Finadine s.c. for analgesia and 0.25 ml penicillin s.c. to prevent infection.…”

(-)-Hydroxycitric Acid Reduced Lipid Droplets Accumulation Via Decreasing Acetyl-Coa Supply and Accelerating Energy Metabolism in Cultured Primary Chicken Hepatocytes

“…Thus, (-)-HCA supplementation is expected to alter metabolic pathways. Although some studies have shown (-)-HCA possesses anti-obesity activity [36, 37] and anti-diabetic activity [38, 39], little information is available on whether (-)-HCA affects fat accumulation in broiler chickens through regulation on the energy metabolism.…”

Updates on Antiobesity Effect ofGarciniaOrigin (−)-HCA

“…A myriad of health effects have been attributed to Garcinia (including G. cambogia, G. atroviridis , and G. indica ), such as antiobesity effects [15–17], antiulcerogenic [18–20], antioxidative [21–24], antidiabetes [25], antimicrobial [22, 26–28], antifungal [29], anti-inflammatory [30, 31], and anticancer effects [22, 32–34]. In particular, the antiobesity effects of Garcinia or more specifically of its HCA content have been elucidated with unprecedented clarity over the last few decades.…”