Hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral<sup>®</sup>) as allergen: experience from a Contact Dermatitis Unit

Carvalho, Rodrigo; Maio, Paula; Amaro, Cristina; Santos, Raquel; Cardoso, Jorge

doi:10.3109/15569527.2011.554484

Cited by 7 publications

(5 citation statements)

References 8 publications

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“…5.9% of investigated products had one or more of the 26 allergens labelled but did not mention "perfume/fragrance/aroma" on the label. Additionally, hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lycral ® ) was found in 13.5% of the tested deodorants, which is a widely used synthetic fragrance for personal care and household products with allergen potential [19].…”

Section: Essential Oilsmentioning

confidence: 99%

Essential Oils and Their Single Compounds in Cosmetics—A Critical Review

2018

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Essential oils are widely incorporated in cosmetic products, perfumes and related household products due to the variety of their properties but mainly due to their pleasant odour. The composition of these volatile natural complex mixtures may vary depending on the quality of plant material from which they were obtained and the extraction method by which they were derived. These factors are also important in ensuring the safe use of essential oils in personal care products. As they contain compounds with varied chemical structure and effects, skin sensitivity and irritations as well as other symptoms may arise after their application. Although essential oils are considered as safe and nontoxic when used at low concentrations, available scientific literature indicates that essential oils and their compounds may possess a strong allergy potential. This review focuses on side effects and allergy contact dermatitis caused by selected essential oils and their single compounds in cosmetic products, summarizing data from the most recent scientific literature.

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Section: Essential Oilsmentioning

confidence: 99%

Essential Oils and Their Single Compounds in Cosmetics—A Critical Review

2018

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“…T he fragrance substance hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) has been a significant contact sensitizer In Europe [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] but not in North America. 16,17 It has been included in the European baseline series both as a single allergen and as 1 of 6 constituents in fragrance mix II (FM II).…”

mentioning

confidence: 99%

Contact Allergy to Fragrance Mix II and Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde: A Retrospective Study by International Contact Dermatitis Research Group

et al. 2020

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Background: Fragrance mix II (FM II) is included in the baseline patch test series recommended by the International Contact Dermatitis Research Group (ICDRG). Hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) is the most important sensitizer of the 6 fragrance materials included in FM II. Besides being a part of FM II, HICC is also tested separately in the ICDRG baseline series.Objectives: The aim of the study was to investigate the prevalence of contact allergy to FM II and HICC in 2012-2016 with a focus on simultaneous reactions and the percentage of missed contact allergy to HICC provided that only FM II had been tested.Patients and Methods: A total of 25,019 consecutive dermatitis patients in 13 dermatology clinics representing 12 countries in 5 continents were patch tested with FM II and HICC in the baseline series.Results: Contact allergy to FM II and HICC was found in 3.9% and 1.6%, respectively. For FM II, the frequency varied from 1.5% to 7.6% in different centers. The corresponding range for HICC was 0.2% to 3.6%. Simultaneous contact allergy to FM II and HICC was noted in 1.4% with the range 0.2% to 2.6%. Seventy-seven patients (0.31%) with contact allergy to HICC did not test positively to FM II. The range for missed HICC allergy by testing only FM II in the different centers would be 0.04% to 0.74%. The ratio between the contact allergy rates for FM II and HICC was similar for all centers, except for Montreal having significantly more contact allergy to FM II than to HICC.Conclusions: The frequency of missed contact allergy to HICC when testing only with FM II was less than 0.5%, therefore questioning the need to test HICC separately in the ICDRG baseline series.

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“…Nitekim çalışmamızda Liral sensitizasyonu ile koku karışımı 1 ve 2 birlikteliğinin anlamlı saptanması da bu alerjenlerin sık sık birlikte temas nedeniyle ortaya çıkmasının işaretçisidir. Daha önce yapılmış çalışmalarda da Liral sensitizasyonunun koku karışımı I-II ve Peru balsamı sensitizasyonu birlikteliğine dikkat çekilmiştir 32 . Yiyecek sektörü çalışanlarının lastik eldivenlerinde saptanan N-izopropiln-fenil-4-fenildiamin ve topikal bir antibikrobial olan kliokinol ile ilişkisi, dermatit nedeniyle başvuruları sırasında verilen tedaviler ve lastik eldiven kullanım sıklıklarından kaynaklanabilir.…”

Section: Grafikunclassified

Clinical and demographic characteristics of patients with occupational contact dermatitis: A 3-year single center experience

Aytekin¹,

Toğral²,

Yılmaz³

et al. 2015

TURKDERM

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Background and Design: Occupational contact dermatitis (OCD) is responsible for 80-90% of the occupational dermatoses. The aim of this work was to evaluate the clinical features of patients with OCD admitted to our hospital. Materials and Methods: The records of patients, who were admitted to our hospital with OCD between December 2009 and January 2013, were evaluated retrospectively. One hundred fifty-nine patients, who were diagnosed with OCD according to the Mathias criteria, were included in the study. Age, sex, location of the lesions, atopic status, glove use, occupational exposure time and total IgE levels of the patients were assessed. Patients with positive allergic reaction with "European Standard Series Skin Patch Test" were identified as allergic OCD and patients with negative test results as "irritant OCD". The clinical features and patch results of patients are evaluated. Results: One hundred fifty-nine patients with a mean age of 39±7.9 years consisted of 151 men and 8 women. The hands were the most common site of OCD; the palms were the most common affected areas of hand eczema. Eighty-one patients (50.1%) were identified to have allergic OCD and 78 (49.9%) as irritant OCD. Irritant OCD was most commonly seen in dental technicians, whereas allergic OCD was most commonly seen in tailors. The top 3 most frequent allergens were potassium dichromate (15.1%), nickel sulfate (9.11%) and cobalt chloride (10.7%). Conclusion: In our country, there has been no comprehensive study presenting the clinical and descriptive characteristics of OCD. For preventing OCD and reducing sick leave we need to have data that belong to our country. Consequently, multicenter studies should be performed for establishing our own database on OCD.

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Hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral^®) as allergen: experience from a Contact Dermatitis Unit

Cited by 7 publications

References 8 publications

Essential Oils and Their Single Compounds in Cosmetics—A Critical Review

Essential Oils and Their Single Compounds in Cosmetics—A Critical Review

Contact Allergy to Fragrance Mix II and Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde: A Retrospective Study by International Contact Dermatitis Research Group

Clinical and demographic characteristics of patients with occupational contact dermatitis: A 3-year single center experience

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Hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral®) as allergen: experience from a Contact Dermatitis Unit

Cited by 7 publications

References 8 publications

Essential Oils and Their Single Compounds in Cosmetics—A Critical Review

Essential Oils and Their Single Compounds in Cosmetics—A Critical Review

Contact Allergy to Fragrance Mix II and Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde: A Retrospective Study by International Contact Dermatitis Research Group

Clinical and demographic characteristics of patients with occupational contact dermatitis: A 3-year single center experience

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Hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral^®) as allergen: experience from a Contact Dermatitis Unit