Hydroxyl radical production in the presence of fibres by a fenton-type reaction

Gulumian, M.; Wyk, J.A. Van

doi:10.1016/0009-2797(87)90081-0

Cited by 71 publications

(23 citation statements)

References 16 publications

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“…(7,8). For example, in studies using cell free systems, iron present on the surface of asbestos fibers can drive a modified Haber-Weiss (Fenton) reaction in which superoxide anion (0-)and hydrogen peroxide (H202) are converted to the highly toxic hydroxyl (-OH) radical (9)(10)(11). In general, the greater the iron content of the fiber, the more AOS generated by this process (12).…”

Section: Mechanisms Of Formation Of Active Oxygen Species By Asbestosmentioning

confidence: 99%

Oxygen Radicals and Asbestos-Mediated Disease

Quinlan¹,

Marsh²,

Janssen³

et al. 1994

Environmental Health Perspectives

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Asbestos fibers are potent elaborators of active oxygen species whether by reactions involving iron on the surface of the fiber, or by attempted phagocytosis of fibers by cell types resident in the lung. The link between production of active oxygen species and the pathogenesis of asbestosmediated disease has been highlighted by studies outlined here exploring the use of antioxidant scavengers which inhibit the cytotoxic effects of asbestos both in vitro and in vivo. The use of antioxidant enzymes ameliorates the induction of certain genes necessary for cell proliferation, such as ornithine decarboxylase, implicating oxidants as causative factors in some abnormal cell replicative events. Based on these observations, antioxidant enzymes likely represent an important lung defense mechanism in response to oxidative stress. In addition, their gene expression in lung or in cells from bronchoalveolar lavage might be a valuable biomarker of chronic inflammation and pulmonary disease after inhalation of oxidants. -Environ Health Perspect 102(Suppl 10): 107-110 (1994)

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Section: Mechanisms Of Formation Of Active Oxygen Species By Asbestosmentioning

confidence: 99%

Oxygen Radicals and Asbestos-Mediated Disease

Quinlan¹,

Marsh²,

Janssen³

et al. 1994

Environmental Health Perspectives

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“…The most potent asbestos (crocidolite or blue asbestos) contains the highest amount of Fe (WHO, 1986). It is explained that Fenton reaction would accelerate the generation of oxygen radical species that lead to carcinogenesis (Jiang et al, 2006;Gulumian and Wyk, 1987).…”

Section: Introductionmentioning

confidence: 99%

Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube

Takagi¹,

Hirose²,

et al. 2008

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-Nanomaterials of carbon origin tend to form various shapes of particles in micrometer dimensions. Among them, multi-wall carbon nanotubes (MWCNT) form fibrous or rod-shaped particles of length around 10 to 20 micrometers with an aspect ratio of more than three. Fibrous particles of this dimension including asbestos and some man-made fibers are reported to be carcinogenic, typically inducing mesothelioma. Here we report that MWCNT induces mesothelioma along with a positive control, crocidolite (blue asbestos), when administered intraperitoneally to p53 heterozygous mice that have been reported to be sensitive to asbestos. Our results point out the possibility that carbon-made fibrous or rodshaped micrometer particles may share the carcinogenic mechanisms postulated for asbestos. To maintain sound activity of industrialization of nanomaterials, it would be prudent to implement strategies to keep good control of exposure to fibrous or rod-shaped carbon materials both in the workplace and in the future market until the biological/ carcinogenic properties, especially of their long-term biodurability, are fully assessed.

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“…In fact, the carcinogenic potency of asbestos is increased by iron, which accelerates the generation of oxygen radical species (Gulumian and van Wyk, 1987;Jiang et al, 2006). Recently, we have proposed a proteomics-based method to evaluate the safety of nanomaterials (Haniu et al, 2009).…”

Section: Introductionmentioning

confidence: 99%