Hydroxylated steroids in C-7 and C-15 positions from progesterone bio-oxidation by the marine-derived fungus Penicillium oxalicum CBMAI 1996

Marine natural products

“…290 The mycelia of a Penicillium oxalicum strain were able to catalyse biotransformation of progesterone to produce the steroid 7β,15β-dihydroxyprogesterone, whilst the culture broth yielded 15β-hydroxyprogesterone, indicating the likely presence of cytochrome P450 monooxygenases in the fungus. 291 Genomic analysis of a Penicillium steckii culture indicated that it contains a large number of secondary metabolite clusters, including one involved in citrinin biosynthesis. Blocking the citrinin biosynthetic pathway resulted in accumulation of three isoquinoline alkaloids.…”

Marine-derived fungi as biocatalysts

“…The mycelia produced the steroid 7β,15β-dihydroxyprogesterone (50), and the culture broth of this fungus yielded the steroid 15β-hydroxyprogesterone (51) by hydroxylation at C-7 and C-15 via cytochrome P-450 monooxygenases. Also, compound 51 was biotransformed by the fungus mycelia to 50 (Figure 3B;de Paula et al, 2021).…”

Estudos Recentes Da Biotransformação Da Progesterona Por Microrganismos

“…Performing the duality product between equation ( 32) and λA 2ø-3 θ, taking advantage of the self-adjointness of the powers of the operator A and using (30), we obtain…”

“…Em nossos estudos foi avaliado o fungo o Penicillium oxalicum CBMAI 1996, frente às reações de biotransformação da progesterona. Esse fungo foi isolado de uma esponja (Chelonaplysilla erecta) coleta do litoral norte do estado de São Paulo [30] . O objetivo de estudar os fungos de ambiente marinho em biotransformações, pois o mar é um dos destinos finais dos esteroides e muitas outras moléculas.…”

“…Águas Residuais 83 Águas Subterrâneas 83,102,103,104,105,106,107,108,116,120,123,124,125,126,127,128,129 Águas Superficiais 105 Analyticity 1,3,5,8,16,18,19,25,27,28,30,32,33,40,53,54 Anticoncepcionais 83,98,99 Aquecimento Global 66,67,69,74,75 Asymptotic Behavior 3,4,5,6,27,29,30,32,37 ,78,84,85,86,87,88,89,90,91,95,…”