Hydroxyphenyl‐1‐methylpyridinium‐jodide als potentielle Reaktivatoren von mit Organophosphor‐Verbindungen vergifteten Acetylcholinesterasen

Abstract

Hydroxyphenyl-1-methylpyridinium-iodide as Potential Reactivators of Acetylcholinesterase Poisoned with Organophosphoms Compounds. HELVETICA CHIMICA ACTA -Vol. 66, Fax. 4 (1 983) -Nr. 103 Schema 6 . Resonanzstabilisiertes Phenolat-ion c _

Cross-Coupling Reactions of Phenylmagnesium Halides with Fluoroazines and Fluorodiazines

“…The physical and spectral data are analogous to those previously described. 27 2-(2-Methoxyphenyl)pyridine (3c). 26 The procedure is as described for 2a but using 2-fluoropyridine (87 µL, 97 mg, 1.0 mmol) instead of 3-fluoropyridine, 2-methoxyphenylmagnesium bromide (1.2 mmol) in THF (1.2 mL) instead of PhMgCl, and Ni(acac) 2 (13 mg, 50 µmol) and dppp (21 mg, 50 µmol) instead of NiCl2(dppe): yield 79% (eluent CH2Cl2/Et2O, 95:5); 1 H NMR (CDCl3) δ 3.87 (s, 3H), 7.02 (d, 1H, J ) 8.3 Hz), 7.09 (t, 1H, J ) 7.5 Hz), 7.2 (m, 1H), 7.37 (td, 1H, J ) 7.8, 1.7 Hz), 7.7 (m, 3H), 8.71 (dd, 1H, J ) 4.3, 1.2 Hz); 13 C NMR (CDCl3) δ 56.…”

Large-Scale Negishi Coupling as Applied to the Synthesis of PDE472, an Inhibitor of Phosphodiesterase Type 4D

“…The combined extracts were washed (methyl tert -butyl ether), basified (aqueous NaOH) and extracted with methyl tert -butyl ether (4 × 300 mL). The combined extracts were dried (Na 2 SO 4 ), and the solvent was evaporated off under reduced pressure to yield the crude product which was purified by recrystallisation from methyl tert -butyl ether−cyclohexane to give 8 (50 g, 93%) as a colorless crystalline solid, mp 94−96 °C (lit . 95−96 °C).…”

Metallaphotoredox-Mediated Csp2–H Hydroxylation of Arenes under Aerobic Conditions

“…To date, significant effort has been dedicated to synthesizing phenol and hydroxylated arenes, as they are the building blocks of many bioactive molecules, pharmaceuticals, polymers, and light-emitting materials. − The direct C–H oxidation leading to hydroxylation is an attractive method for generating important phenol products. , In 2009, Yu et al showed carboxylic group directed ortho-hydroxylation of benzoic acids using a Pd-catalyst with 1 atm of O 2 or air . The same group has also explored the Cu­(II)-catalyzed ortho-C–H hydroxylation of aryl C–H bonds .…”