Hydroxypropyl methylcellulose hydrogel of berberine chloride-loaded escinosomes: Dermal absorption and biocompatibility

Vanti, Giulia; Wang, Meng; Bergonzi, Maria Camilla; Liu, Zhidong; Bilia, Anna Rita

doi:10.1016/j.ijbiomac.2020.07.129

Cited by 45 publications

(21 citation statements)

References 20 publications

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“…Vegetable-derived molecules, i.e., polyphenols, which are responsible of a wide range of bioactivities (antioxidant, antiaging, antimicrobial and antitumoral features), have a limited water solubility [ 6 ] and a need for suitable delivery systems to reach the target tissue. This is the case of berberine, an isoquinoline derivative exploited for its antinflammatory and antimicrobial properties: its embedding in topical products (i.e., vesicular carriers, gel delivery systems and cream formulations) has been exploited to treat several skin conditions, including wound healing [ 7 , 8 ]. Recently, an amino acid/berberine hydrogel and a silk-sericin derived hydrogel loaded with berberine confirmed the antimicrobial activity of berberine against Gram-positive bacteria than Gram-negative ones [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Innovative Eco-Friendly Hydrogel Film for Berberine Delivery in Skin Applications

Cometa¹,

Bonifacio

Licini

et al. 2021

Molecules

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Hydrogel formulations (masks or patches, without tissue support) represent the new frontier for customizable skin beauty and health. The employment of these materials is becoming popular in wound dressing, to speed up the healing process while protecting the affected area, as well as to provide a moisturizing reservoir, control the inflammatory process and the onset of bacterial development. Most of these hydrogels are acrylic-based at present, not biodegradable and potentially toxic, due to acrylic monomers residues. In this work, we selected a new class of cellulose-derived and biodegradable hydrogel films to incorporate and convey an active compound for dermatological issues. Films were obtained from a combination of different polysaccharides and clays, and berberine hydrochloride, a polyphenolic molecule showing anti-inflammatory, immunomodulatory, antibacterial and antioxidant properties, was chosen and then embedded in the hydrogel films. These innovative hydrogel-based systems were characterized in terms of water uptake profile, in vitro cytocompatibility and skin permeation kinetics by Franz diffusion cell. Berberine permeation fitted well to Korsmeyer–Peppas kinetic model and achieved a release higher than 100 µg/cm2 within 24 h. The latter study, exploiting a reliable skin model membrane, together with the biological assessment, gained insights into the most promising formulation for future investigations.

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Section: Introductionmentioning

confidence: 99%

Innovative Eco-Friendly Hydrogel Film for Berberine Delivery in Skin Applications

Cometa¹,

Bonifacio

Licini

et al. 2021

Molecules

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“…Recently, to increase the skin bioavailability of berberine, Giulia Vanti and his research group prepared berberine-loaded escinosomes, and they proved that hydrogels formulated with berberine-loaded escinosomes had the highest berberine skin absorption both in terms of absorbed dose and of dose retained inside the skin. 6,7 Therefore, a novel formulation that improves the skin permeability and retention of BH would greatly increase the antibacterial effects of the drug and the compliance of patients.…”

Section: Introductionmentioning

confidence: 99%

<p>Berberine-Loaded Thiolated Pluronic F127 Polymeric Micelles for Improving Skin Permeation and Retention</p>

Niu¹,

Yuan²,

Chen³

et al. 2020

IJN

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“…The encapsulation efficiency (EE%) of khellin was evaluated using a direct method [ 15 ] by the dialysis bag method. Briefly, 2 mL of nanovesicles were put into a Spectra/Por ® dialysis tubing of regenerated cellulose a with molecular weight cut-off of 3.5 KDa (Repligen Europe B.V., Breda, The Netherlands).…”

Section: Methodsmentioning

confidence: 99%

The Anti-Arthritic Efficacy of Khellin Loaded in Ascorbyl Decanoate Nanovesicles after an Intra-Articular Administration

et al. 2021

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Osteoarthritis is the most widespread joint-affecting disease. The management of persistent pain remains inadequate and demands new therapeutic strategies. In this study, we explored the pain relieving and protective properties of a single intra-articular (i.a.) injection of khellin loaded in nanovesicles (K-Ves) based on ascorbyl decanoate plus phosphatidylcholine in a rat model of osteoarthritis (OA) induced by monosodium iodoacetate (MIA) treatment. The developed nanovesicles (approximately 136 nm) had a narrow size distribution (PdI 0.26), a good recovery (about 80%) and a worthy encapsulation efficiency (about 70%) with a ζ-potential of about −40 mV. The stability of K-Ves was assessed in simulated synovial fluid. Seven days after the articular damage with MIA, both K-Ves and a suspension of khellin (K, 50 μL) were i.a. injected. K-Ves significantly counteracted MIA-induced hypersensitivity to mechanical noxious (paw pressure test) and non-noxious stimuli (von Frey test) and significantly reduced the postural unbalance related to spontaneous pain (incapacitance test) and the motor alterations (beam balance test) 7 and 14 days after the i.a. injection. K was partially active only on day 7 after the treatment. The histology emphasized the improvement of several morphological factors in MIA plus K-Ves-treated animals. In conclusion, K-Ves could be successfully used for the local treatment of osteoarthritis.

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Hydroxypropyl methylcellulose hydrogel of berberine chloride-loaded escinosomes: Dermal absorption and biocompatibility

Cited by 45 publications

References 20 publications

Innovative Eco-Friendly Hydrogel Film for Berberine Delivery in Skin Applications

Innovative Eco-Friendly Hydrogel Film for Berberine Delivery in Skin Applications

<p>Berberine-Loaded Thiolated Pluronic F127 Polymeric Micelles for Improving Skin Permeation and Retention</p>

The Anti-Arthritic Efficacy of Khellin Loaded in Ascorbyl Decanoate Nanovesicles after an Intra-Articular Administration

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