Hydroxytyrosol: Bioavailability, toxicity, and clinical applications

Robles-Almazán, María; Pulido-Morán, Mario; Moreno‐Fernández, Jorge; Ramírez-Tortosa, César L.; Rodríguez-García, Carmen; Quiles, José L.; Ramírez-Tortosa, M. C.

doi:10.1016/j.foodres.2017.11.053

Cited by 240 publications

(248 citation statements)

References 164 publications

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“…As mentioned above, olive oil phenolic compounds (OOPCs) are now believed to contribute to the health benefits attributed to extra virgin olive oil (EVOO; Crespo et al, ; Robles‐Almazan et al, ). Indeed, the soluble fraction of olive oil is mainly composed of OOPC, including phenolic acids, phenolic alcohols (HT and tyrosol), secoiridoids such as oleuropein (OLE), HT linked to the dialdehydic form of elenolic acid (3,4‐EDA), and flavonoids (Rodriguez‐Morato et al, ).…”

Section: Olive Oil and Its Major Componentsmentioning

confidence: 99%

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An overview of the pharmacology of olive oil and its active ingredients

Visioli

Dávalos

Hazas

et al. 2019

British J Pharmacology

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In addition to providing sensory stimuli, usually taste, smell and sight, olive oil contains a range of minor components, mostly phenolic in nature. These components are endowed with pharmacological or pharma‐nutritional properties that are the subject of active research worldwide. Based on our more than 25 years of experience in this field, we critically focus on what we believe are the most pharmacologically prominent actions of the constituents of olive oil. Most of the effects are due to the phenolic compounds in extra virgin olive oil, such as hydroxytyrosol and oleocanthal (which are often mis‐categorized as in vivo antioxidants) and concern the cardiovascular system. Other potentially beneficial activities are still to be investigated in depth. We conclude that—in the context of a proper diet that includes high‐quality products—the use of high‐quality olive oil contributes to achieving and sustaining overall health. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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Section: Olive Oil and Its Major Componentsmentioning

confidence: 99%

“…As mentioned above, olive oil phenolic compounds (OOPCs) are now believed to contribute to the health benefits attributed to extra virgin olive oil (EVOO; Crespo et al, 2018;Robles-Almazan et al, 2018).…”

Section: Phenolic Compoundsmentioning

confidence: 99%

An overview of the pharmacology of olive oil and its active ingredients

Visioli

Dávalos

Hazas

et al. 2019

British J Pharmacology

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“…Olive oils are the liquid fats obtained from olives and the most important food in the Mediterranean diet and one of the most important sources of the monounsaturated fatty acids. Consumption of olive oils also links with greater longevity and lower rates of cardiovascular diseases and management of cancer (Granados‐Principal, Quiles, Ramirez‐Tortosa, Sanchez‐Rovira, & Ramirez‐Tortosa, ; Lopez‐Miranda et al, ; Perez‐Jimenez, Ruano, Perez‐Martinez, Lopez‐Segura, & Lopez‐Miranda, ; Reboredo‐Rodríguez et al, ; Robles‐Almazan et al, ). Oleocanthal, a phenolic compound present in extra origin virgin olive oils, reduces cellular viability selectively via lysosomal membrane permeabilization in cancer cells (LeGendre, Breslin, & Foster, ).…”

Section: Some Common Phytochemicals With Chemopreventive and Chemothementioning

confidence: 99%

Phytochemicals based chemopreventive and chemotherapeutic strategies and modern technologies to overcome limitations for better clinical applications

Singh

Arora

Ansari

et al. 2019

Phytotherapy Research

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Naturally occurring phytochemicals or plant derivatives are now being explored extensively for their health's benefits and medicinal uses. The therapeutic effect of phytochemicals has been reported in several pathophysiological settings such as inflammatory disorders, metabolic disorders, liver dysfunction, neurodegenerative disorders, and nephropathies. However, the most warranted therapeutic effects of phytochemicals were mapped to their anticancerous and chemopreventive action. Moreover, combining phytochemicals with standard chemotherapy has shown promising results in cancer therapy with minimal side effects and better efficacy. Many phytochemicals, like curcumin, resveratrol, and epigallocatechin‐3‐gallate, have been extensively investigated for their chemopreventive as well as chemotherapeutic effects. However, poor bioavailability, low solubility, hydrophobicity, and obscure target specificity restrict their therapeutic applications in the clinic. There has been a continually increasing interest to formulate nanoformulations of phytochemicals by using various nanocarriers, such as liposomes, micelles, nanoemulsions, and nanoparticles, to improve their bioavailability and target specificity, thereby maximizing the therapeutic potential. In the present review, we have summarized chemopreventive as well as chemotherapeutic action of some common phytochemicals and their major limitations in clinical application. Also, we have given an overview of strategies that can improve the efficacy of phytochemicals for their chemotherapeutic value in clinical settings.

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“…Traditional MD is characterized by high intake of cereals, vegetables, fruits, nuts, legumes, low intake of meat and meat products, a moderate intake of fish and seafood and a modest consumption of alcohol [17], accompanied by a regular intake of olive oil (OO), mainly virgin OO (VOO) or extra virgin OO (EVOO), of which consumption typically ranges between 25 and 50 mL (approximately two tablespoons) per day [18,19]. Actually, different authors have stated the NCDs lowered incidences to OO intake, at least in part.…”

Section: Olive Oil and Phenolic Compoundsmentioning

confidence: 99%

Phenolic Compounds Isolated from Olive Oil as Nutraceutical Tools for the Prevention and Management of Cancer and Cardiovascular Diseases

Reboredo‐Rodríguez

Varela-López

Forbes-Hernández

et al. 2018

IJMS

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Non-communicable diseases (NCDs) have become the largest contributor to worldwide morbidity and mortality. Among them, cancer and cardiovascular diseases (CVDs) are responsible for a 47% of worldwide mortality. In general, preventive approaches modifying lifestyle are more cost-effective than treatments after disease onset. In this sense, a healthy diet could help a range of NCDs, such as cancer and CVDs. Traditional Mediterranean Diet (MD) is associated by the low-prevalence of certain types of cancers and CVDs, where olive oil plays an important role. In fact, different epidemiological studies suggest that olive oil consumption prevents some cancers, as well as coronary heart diseases and stroke incidence and mortality. Historically, the beneficial health effects of virgin olive oil (VOO) intake were first attributed to the high concentration of monounsaturated fatty acids. Nowadays, many studies indicate that phenolic compounds contained in olive oil have positive effects on different biomarkers related to health. Among them, phenolic compounds would be partially responsible for health benefits. The present work aims to explore, in studies published during the last five years, the effects of the main phenolic compounds isolated from olive oil on different cancer or CVD aspects, in order to clarify which compounds have more potential to be used as nutraceuticals with preventive or even therapeutic properties.

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Hydroxytyrosol: Bioavailability, toxicity, and clinical applications

Cited by 240 publications

References 164 publications

An overview of the pharmacology of olive oil and its active ingredients

An overview of the pharmacology of olive oil and its active ingredients

Phytochemicals based chemopreventive and chemotherapeutic strategies and modern technologies to overcome limitations for better clinical applications

Phenolic Compounds Isolated from Olive Oil as Nutraceutical Tools for the Prevention and Management of Cancer and Cardiovascular Diseases

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