Hydroxytyrosol (HT) Analogs Act as Potent Antifungals by Direct Disruption of the Fungal Cell Membrane

Diallinas, George; Rafailidou, Nausica; Kalpaktsi, Ioanna; Komianou, Aikaterini Christina; Tsouvali, Vivian; Zantza, Iliana; Mikros, Emmanuel; Skaltsounis, Alexios Léandros; Kostakis, Ioannis K.

doi:10.3389/fmicb.2018.02624

Cited by 18 publications

(11 citation statements)

References 46 publications

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“…Regarding the antimicrobial action, the most studied natural compounds are phenolics, although the action of oligopeptides, terpenoids or macrolides have also been reported [ 10 , 11 , 12 , 13 ].…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition and Antimicrobial Activity of a New Olive Pomace Functional Ingredient

et al. 2021

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Olive pomace, an olive oil processing byproduct, can be upcycled and meet the current demand for natural and sustainable food ingredients. In this work, a patented process was used to obtain a functional ingredient from different olive pomaces. The nutritional, chemical and antioxidant profiles, as well as the antimicrobial activity against S. aureus, E. coli and C. albicans, were investigated for the first time. The amount of phenolics ranged between 3.1 and 3.8 g gallic acid eq./100 g in all samples and flavonoids between 2.0 and 3.2 g catechin eq/100 g. No significant differences were found regarding the antioxidant activity. The total fat varied between 5 and 11%, α-tocopherol being the major vitamer and oleic acid the main fatty acid. The protein and ash contents were 1–4% and 10–17%, respectively. The functional ingredient with a higher hydroxytyrosol content (220 mg/100 g) also presented the best minimal inhibitory concentration against the tested bacteria. No activity against C. albicans was verified. This new functional ingredient presents the potential to be used as a natural preservative or as a nutritional profile enhancer. Moreover, it can be an advantageous ingredient in food products, since it comprises specific lipid and hydrophilic bioactive compounds usually not present in other plant extracts.

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Section: Resultsmentioning

confidence: 99%

Chemical Composition and Antimicrobial Activity of a New Olive Pomace Functional Ingredient

et al. 2021

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“…The antifungal activity of a series of chemically synthesized HTyr analogs was investigated. Using Aspergillus nidulans as an in vivo cellular model system, it was shown that antifungal HTyr analogs have an unprecedented efficiency in fungal plasma membrane destruction [93]. It was demonstrated that HTyr has antitrypanosomal and antileishmanial activity [94].…”

Section: Hydroxytyrosolmentioning

confidence: 99%

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

et al. 2019

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The Mediterranean diet and olive oil as its quintessential part are almost synonymous with a healthy way of eating and living nowadays. This kind of diet has been highly appreciated and is widely recognized for being associated with many favorable effects, such as reduced incidence of different chronic diseases and prolonged longevity. Although olive oil polyphenols present a minor fraction in the composition of olive oil, they seem to be of great importance when it comes to the health benefits, and interest in their biological and potential therapeutic effects is huge. There is a growing body of in vitro and in vivo studies, as well as intervention-based clinical trials, revealing new aspects of already known and many new, previously unknown activities and health effects of these compounds. This review summarizes recent findings regarding biological activities, metabolism and bioavailability of the major olive oil phenolic compounds—hydroxytyrosol, tyrosol, oleuropein, oleocanthal and oleacein—the most important being their antiatherogenic, cardioprotective, anticancer, neuroprotective and endocrine effects. The evidence presented in the review concludes that these phenolic compounds have great pharmacological potential, however, further studies are still required.

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“…HTyr has been reported to have antiatherogenic, cardioprotective [ 145 , 146 ], anticancer [ 147 , 148 ], neuroprotective [ 149 , 150 ], antimicrobial [ 151 , 152 ], anti-inflammatory, and antiplatelet properties [ 66 , 153 ]. It is released by OLE hydrolysis, which also gives rise to OLE aglycone and elenolic acid [ 154 ].…”

Section: Resultsmentioning

confidence: 99%

Potential Effects of Phenolic Compounds That Can Be Found in Olive Oil on Wound Healing

Melguizo‐Rodríguez

Luna-Bertos

Ramos‐Torrecillas

et al. 2021

Foods

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The treatment of tissue damage produced by physical, chemical, or mechanical agents involves considerable direct and indirect costs to health care systems. Wound healing involves a series of molecular and cellular events aimed at repairing the defect in tissue integrity. These events can be favored by various natural agents, including the polyphenols in extra virgin olive oil (EVOO). The objective of this study was to review data on the potential effects of different phenolic compounds that can also be found in EVOO on wound healing and closure. Results of in vitro and animal studies demonstrate that polyphenols from different plant species, also present in EVOO, participate in different aspects of wound healing, accelerating this process through their anti-inflammatory, antioxidant, and antimicrobial properties and their stimulation of angiogenic activities required for granulation tissue formation and wound re-epithelialization. These results indicate the potential usefulness of EVOO phenolic compounds for wound treatment, either alone or in combination with other therapies. Human studies are warranted to verify this proposition.

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Hydroxytyrosol (HT) Analogs Act as Potent Antifungals by Direct Disruption of the Fungal Cell Membrane

Cited by 18 publications

References 46 publications

Chemical Composition and Antimicrobial Activity of a New Olive Pomace Functional Ingredient

Chemical Composition and Antimicrobial Activity of a New Olive Pomace Functional Ingredient

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

Potential Effects of Phenolic Compounds That Can Be Found in Olive Oil on Wound Healing

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