Hydroxytyrosol nicotinate, a new multifunctional hypolipidemic and hypoglycemic agent

Xie, Yundong; Chen, Zizhang; Li, Na; Lu, Wen-Fang; Yan, Xu; Lin, Yuanyuan; Shao, Li‐Hua; Wang, Qiutang; Guo, Liying; Gao, Yali; Yang, Guangde; Li, Yiping; Bian, Xiaoli

doi:10.1016/j.biopha.2018.01.123

Cited by 18 publications

(11 citation statements)

References 32 publications

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“…This dose did not influence blood lipids, but endogenous vitamin C levels were increased [36]. Moreover, HTyr-nicotinate, HTyr-clofibrate and HTyr-fenofibrate showed the antihyperlipidemic effect [37,38,39]. HTyr and HTyr-acetate (HTyr-Ac) were proved to prevent platelet aggregation, one of the factors involved in thrombotic processes, with effects similar to acetylsalicylic acid [40].…”

Section: Hydroxytyrosolmentioning

confidence: 99%

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

et al. 2019

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The Mediterranean diet and olive oil as its quintessential part are almost synonymous with a healthy way of eating and living nowadays. This kind of diet has been highly appreciated and is widely recognized for being associated with many favorable effects, such as reduced incidence of different chronic diseases and prolonged longevity. Although olive oil polyphenols present a minor fraction in the composition of olive oil, they seem to be of great importance when it comes to the health benefits, and interest in their biological and potential therapeutic effects is huge. There is a growing body of in vitro and in vivo studies, as well as intervention-based clinical trials, revealing new aspects of already known and many new, previously unknown activities and health effects of these compounds. This review summarizes recent findings regarding biological activities, metabolism and bioavailability of the major olive oil phenolic compounds—hydroxytyrosol, tyrosol, oleuropein, oleocanthal and oleacein—the most important being their antiatherogenic, cardioprotective, anticancer, neuroprotective and endocrine effects. The evidence presented in the review concludes that these phenolic compounds have great pharmacological potential, however, further studies are still required.

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Section: Hydroxytyrosolmentioning

confidence: 99%

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

et al. 2019

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“…The study also examined the effect of HT on Triton WR-1339 induced-hyperlipidemic mice further confirming the improvement in lipid profile (decrease in total cholesterol, triglycerides, LDL-cholesterol) and antioxidant activity (MDA decrease) [72]. Another study administered HT-nicotinamide (HT-N) or pure HT (both 0.38 mmol/kg by intragastric gavage) for 4 weeks in streptozotocin and high-fat diet (60 mg/kg for 7 days after 6 weeks of high-fat diet) - induced diabetic Kun Ming (KM) mice [73]. Results showed that both HT-N and HT caused a reduction in plasma glucose levels, total cholesterol, and triglycerides, while increasing the antioxidant activities of SOD, CAT, and GSH-PX.…”

Section: In Vivo Evidence: Antidiabetic Effect Of Hydroxytyrosolmentioning

confidence: 99%

“…Additionally, treatment with both HT-N and HT showed a protective effect on pancreatic tissue and inhibited the destruction of β cells. The study also investigated the effect of HT on hyperlipidemic mice (induced with 400 mg/kg Triton WR-1339) showing decreased plasma triglyceride, cholesterol, and MDA levels [73]. In another study, Xie et al (2018) investigated the effects of hydroxytyrosol-clofibrate (CF-HT, 240 µmol/kg/day for 7 days) in hyperlipidemic mice (induced with Triton WR-1339) showing decreased plasma total cholesterol and triglyceride levels, a protective effect on hepatic tissue (decreased AST, ALT, total bilirubin (TBIL), alkaline phosphatase (ALP)), and increased serum SOD and CAT.…”

Section: In Vivo Evidence: Antidiabetic Effect Of Hydroxytyrosolmentioning

confidence: 99%

“…The studies using rodents with diabetes induced by alloxan or streptozotocin showed that HT may decrease serum glucose and lipid levels, mitigate inflammation, and significantly reduce oxidative stress. The harmful impact of hyperglycemia and lack of insulin production on the liver, heart, brain, pancreas, and retinal cells of the eye were also alleviated by HT [47,55,56,58,59,60,61,62,72,73,74]. Secondary experiments using Triton WR-1339 to chemically induce hyperlipidemia also showed that HT decreased serum lipids and liver damage [72,74].…”

Section: In Vivo Evidence: Antidiabetic Effect Of Hydroxytyrosolmentioning

confidence: 99%

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Antidiabetic Effects of Hydroxytyrosol: In Vitro and In Vivo Evidence

2019

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Insulin resistance, a pathological condition characterized by defects in insulin action leads to the development of Type 2 diabetes mellitus (T2DM), a disease which is currently on the rise that pose an enormous economic burden to healthcare systems worldwide. The current treatment and prevention strategies are considerably lacking in number and efficacy and therefore new targeted therapies and preventative strategies are urgently needed. Plant-derived chemicals such as metformin, derived from the French lilac, have been used to treat/manage insulin resistance and T2DM. Other plant-derived chemicals which are not yet discovered, may have superior properties to prevent and manage T2DM and thus research into this area is highly justifiable. Hydroxytyrosol is a phenolic phytochemical found in olive leaves and olive oil reported to have antioxidant, anti-inflammatory, anticancer and antidiabetic properties. The present review summarizes the current in vitro and in vivo studies examining the antidiabetic properties of hydroxytyrosol and investigating the mechanisms of its action.

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“…To avoid these problems, the esterification could be performed using both enzymatic or chemical procedures [ 19 , 20 ]. As an example, HTyr nicotinate and HTyr lipoate were synthetized by chemical procedures including the protection and then the deprotection of the catecholic moiety of HTyr [ 21 , 22 ], while lipophilic HTyr esters were generally prepared enzymatically using Candida antarctica lipase B [ 23 , 24 ]. As an alternative, recently in our laboratories, two chemical procedures have been optimized to obtain lipophilic HTyr esters.…”

Section: Resultsmentioning

confidence: 99%

New Dihydroxytyrosyl Esters from Dicarboxylic Acids: Synthesis and Evaluation of the Antioxidant Activity In Vitro (ABTS) and in Cell-Cultures (DCF Assay)

Roma

Mattoni²,

Lupattelli

et al. 2020

Molecules

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New dihydroxytyrosyl esters 2a, 2c–2j of dicarboxylic acids were synthesized from methyl orthoformate protected hydroxytyrosol 3 and diacyl chlorides. New compounds were characterized (HRMS, FT-IR, 1H- and 13C-NMR), and tested for antioxidant activity both in vitro (ABTS) and on L6 myoblasts and THP1 leukemic monocytes cell culture by DCF assay. According to the ABTS assay, compounds 2a, 2c–2j showed a TEAC value of antioxidant capacity up to twice that of Trolox. Very high or complete ROS protections were obtained in the cell environment where lipophilicity and rigidity of dicarboxylic structure seem to facilitate the antioxidant effect. MTT assay and proliferation test were used for assessment of cell viability. These compounds can be envisaged as a new class of preservatives for food or cosmetic products.

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Hydroxytyrosol nicotinate, a new multifunctional hypolipidemic and hypoglycemic agent

Cited by 18 publications

References 32 publications

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

Antidiabetic Effects of Hydroxytyrosol: In Vitro and In Vivo Evidence

New Dihydroxytyrosyl Esters from Dicarboxylic Acids: Synthesis and Evaluation of the Antioxidant Activity In Vitro (ABTS) and in Cell-Cultures (DCF Assay)

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