Hydroxyvitamin D Serum Levels are Negatively Associated with Platelet Number in a Cohort of Subjects Affected by Overweight and Obesity

Zupo, Roberta; Castellana, Fabio; Sardone, Rodolfo; Lampignano, Luisa; Noia, Carmen Di; Savastano, Silvia; Giannelli, Gianluigi; Pergola, Giovanni De

doi:10.3390/nu12020474

Cited by 12 publications

(9 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…leucocytes, erythrocytes, and platelets (Table 2 ). Inverse associations of vitamin D with platelet counts [ 24 , 25 ], erythrocyte counts [ 25 , 26 ], and leukocyte counts [ 25 ] have also been described in the literature, but in some populations there was either no clear correlation (e.g., with leukocyte count in a Brazilian population [ 27 ]) or a positive correlation (e.g., with platelets in [ 28 ]). In the Brazilian study, there was no clear association between vitamin D and total leucocyte count, but a significant negative association between eosinophil count and vitamin D [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Low Vitamin D Status in a Cancer Patient Population from Franconia, Germany

Klement¹,

Koebrunner²,

Krage³

et al. 2020

Complement Med Res

View full text Add to dashboard Cite

Background: Vitamin D has been shown to be associated with reduced risk and severity of COVID-19 and exerts regulating effects on all hallmarks of cancer. The goal of this study was to analyze the vitamin D status of a cancer patient cohort from our clinic in the Franconian region, Germany. Methods: 25-hydroxyvitamin D concentrations were available for 116 patients included in prospective trials in our clinic. Associations of vitamin D with anthropometric and blood parameters were investigated using Kendall’s τ correlation coefficients and linear regression. Results: A total of 57 patients (49.1%) were vitamin D deficient (<20 ng/mL), and 92.2% did not meet the recommended vitamin D level of 40 ng/mL. There was a strong negative association between vitamin D and leukocyte count (τ = –0.173, p = 0.007) and C-reactive protein concentration (τ = –0.172, p = 0.007). In linear regression, the most important variables for predicting vitamin D levels were (in order of decreasing importance) season, fat mass index, platelet, and leukocyte count. Conclusions: Despite appeals towards medical societies to target widespread vitamin D deficiency in Germany more than 10 years ago, our data indicate that these have been without avail. Low vitamin D levels in cancer patients should be corrected using reasonable sun exposure and supplements.

show abstract

Section: Discussionmentioning

confidence: 99%

Low Vitamin D Status in a Cancer Patient Population from Franconia, Germany

Klement¹,

Koebrunner²,

Krage³

et al. 2020

Complement Med Res

View full text Add to dashboard Cite

show abstract

“…Vitamin D is a fat-soluble vitamin that is essential for the metabolism of calcium and phosphorus, and the regulation of bone tissue [1]. Additionally, vitamin D has been acknowledged to influence different functions with regard to the immune, nervous, cardiovascular and endocrine systems [2,3]. Despite different foods contain vitamin D (i.e., fish), about 80% of the daily requirement of this vitamin is assured by its synthesis at the skin level through sun exposure (ultraviolet B (UVB) radiation).…”

Section: Introductionmentioning

confidence: 99%

Obesity and Circulating Levels of Vitamin D before and after Weight Loss Induced by a Very Low-Calorie Ketogenic Diet

Buscemi

Corleo

et al. 2021

Nutrients

Self Cite

View full text Add to dashboard Cite

Background: Vitamin D plays a pivotal role in calcium and phosphorus metabolism, also influencing bone tissue. Several studies have reported that vitamin D blood levels were significantly lower in people with obesity, probably due to its uptake by the adipose tissue. Clinical studies that investigated the changes of circulating levels of vitamin D following weight loss reported controversial data. A very low-calorie ketogenic diet is acknowledged as a reliable treatment to achieve a rapid weight loss. Therefore, we investigated the effect of weight loss, consequent to a very low-calorie ketogenic diet, on vitamin D blood concentrations. Methods: A cohort of 31 people with obesity underwent a very low-calorie ketogenic diet for 10–12 weeks. The serum concentrations of vitamin D, parathormone, calcium and phosphorous were measured before and after weight loss; they were compared to a control group of 20 non-obese, non-diabetic, age- and gender-matched persons. Results: Patients with obesity had a higher habitual intake of vitamin D than the control group (p < 0.05). However, the vitamin D blood levels of the obese group were significantly lower than those of the control group (p < 0.005) and they increased after weight loss (p < 0.001). At baseline, vitamin D blood concentrations of the persons with obesity were significantly correlated with both fat mass–kg (r = −0.40; p < 0.05) and body mass index (r = −0.47; p < 0.01). Following very low-calorie ketogenic diet, the change in vitamin D serum concentrations was correlated only with the change in fat mass–kg (r = −0.43; p < 0.01). Conclusion: This study confirmed that patients with obesity have lower vitamin D levels that normalize after significant weight loss, supporting the hypothesis that vitamin D is stored in the adipose tissue and released following weight loss.

show abstract

“…14 Inflammation was reported to result in an increase in platelet activation and platelet counts. 7 There was an inverse correlation between vitamin D and inflammatory markers in a study. 15 Lower vitamin D levels were thought to be related with inflammation and elevated cytokine levels that will cause an increase in platelet counts.…”

Section: Discussionmentioning

confidence: 93%

“…There are studies reporting higher platelet counts in people who have vitamin D deficiency. [5][6][7] Two of these studies inspected general population in adult ages and one inspected obese and overweight people. Vitamin D was reported to affect hematopoietic cell proliferation and differentiation.…”

Section: Discussionmentioning

confidence: 99%