Hylan G-F 20 Improves Hip Osteoarthritis: A Prospective, Randomized Study

Spitzer, Andrew I.; Bockow, Barry; Brander, Victoria A.; Yates, James; MacCarter, Daryl K.; Gudger, Garland K.; Haller, Stephanie; Lake, Stephen; Magilavy, Daniel B.

doi:10.3810/psm.2010.06.1781

Cited by 42 publications

(38 citation statements)

References 33 publications

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“…In this study, both hylan G-F 20 and MPA yielded clinically meaningful improvements in pain and function ( P < 0.0001) compared with baseline [80]. Response rates were higher for patients with grade 3 hip OA treated with hylan G-F 20 compared with MPA-treated patients, while similar relief was found for patients with grade 2 hip OA [80]. In addition, hylan G-F 20 also demonstrated effectiveness in one observational [81] and one retrospective study [82], relieving symptoms and improving hip function in patients eligible for total hip replacement.…”

Section: Efficacy Of Viscosupplementation In Other Jointsmentioning

confidence: 84%

“…To date, their off-label use has been investigated in clinical studies in a number of other joints, including the hip. Spitzer et al [80] conducted a large, prospective, randomized, double-blind trial, where 305 patients were randomized to two injections of hylan G-F 20 administered 2 weeks apart ( n = 150), or 1 injection of 40 mg methylprednisolone acetate (MPA) and 1 sham injection 2 weeks later ( n = 155). WOMAC total and subscale scores, clinician observations, and patient global assessments were collected at baseline and at 4, 8, 12, 16, 20, and 26 weeks [80].…”

Section: Efficacy Of Viscosupplementation In Other Jointsmentioning

confidence: 99%

“…Spitzer et al [80] conducted a large, prospective, randomized, double-blind trial, where 305 patients were randomized to two injections of hylan G-F 20 administered 2 weeks apart ( n = 150), or 1 injection of 40 mg methylprednisolone acetate (MPA) and 1 sham injection 2 weeks later ( n = 155). WOMAC total and subscale scores, clinician observations, and patient global assessments were collected at baseline and at 4, 8, 12, 16, 20, and 26 weeks [80]. In this study, both hylan G-F 20 and MPA yielded clinically meaningful improvements in pain and function ( P < 0.0001) compared with baseline [80].…”

Section: Efficacy Of Viscosupplementation In Other Jointsmentioning

confidence: 99%

“…WOMAC total and subscale scores, clinician observations, and patient global assessments were collected at baseline and at 4, 8, 12, 16, 20, and 26 weeks [80]. In this study, both hylan G-F 20 and MPA yielded clinically meaningful improvements in pain and function ( P < 0.0001) compared with baseline [80]. Response rates were higher for patients with grade 3 hip OA treated with hylan G-F 20 compared with MPA-treated patients, while similar relief was found for patients with grade 2 hip OA [80].…”

Section: Efficacy Of Viscosupplementation In Other Jointsmentioning

confidence: 99%

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Viscosupplementation for Osteoarthritis: a Primer for Primary Care Physicians

Reid

2013

Adv Ther

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Introduction Osteoarthritis (OA) constitutes a growing public health burden and the most common cause of disability in the United States. Non-pharmacologic modalities and conservative pharmacologic therapies are recommended for the initial treatment of OA, including acetaminophen, and topical and oral non-steroidal anti-inflammatory drugs. However, safety concerns continue to mount regarding the use of these treatments and none have been shown to impact disease progression. Viscosupplementation with injections of hyaluronans (HAs) are indicated when non-pharmacologic and simple analgesics have failed to relieve symptoms (e.g., pain, stiffness) associated with knee OA. This review evaluates literature focusing on the efficacy and/or safety of HA injections in treating OA of the knee and in other joints, including the hip, shoulder, and ankle. Methods Relevant literature on intra-articular (IA) HA injections as a treatment for OA pain in the knee and other joints was identified through PubMed database searches from inception until January 2013. Search terms included “hyaluronic acid” or “hylan”, and “osteoarthritis”. Discussion Current evidence indicates that HA injections are beneficial and safe for patients with OA of the knee. IA injections of HAs treat the symptoms of knee OA and may also have disease-modifying properties, potentially delaying progression of OA. Although traditionally reserved for second-line treatment, evidence suggests that HAs may have value as a first-line therapy in the treatment of knee OA as they have been shown to be more effective in earlier stages and grades of disease, more recently diagnosed OA, and in less severe radiographic OA. Conclusion For primary care physicians who treat and care for patients with OA of the knee, IA injection with HAs constitutes a safe and effective treatment that can be routinely administered in the office setting.

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Section: Efficacy Of Viscosupplementation In Other Jointsmentioning

confidence: 84%

Section: Efficacy Of Viscosupplementation In Other Jointsmentioning

confidence: 99%

Section: Efficacy Of Viscosupplementation In Other Jointsmentioning

confidence: 99%

Section: Efficacy Of Viscosupplementation In Other Jointsmentioning

confidence: 99%

See 2 more Smart Citations

Viscosupplementation for Osteoarthritis: a Primer for Primary Care Physicians

Reid

2013

Adv Ther

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“…Intra-articular injection of hyaluronic acid is still controversial in the management of hip osteoarthritis (OA), as its efficacy has not been clearly established. 3,[5][6][7][8][9] More recently, intra-articular injections of platelet-rich plasma (PRP) have been proposed but presently there is a paucity of data supporting its wide use in clinical practice.…”

Section: Intra-articular Aspirations and Injectionsmentioning

confidence: 99%

Interventional MSK procedures: the hip

Dodré¹,

Lefebvre²,

Cockenpot³

et al. 2016

BJR

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Percutaneous musculoskeletal procedures are widely accepted as low invasive, highly effective, efficient and safe methods in a vast amount of hip pathologies either in diagnostic or in therapeutic management. Hip intra-articular injections are used for the symptomatic treatment of osteoarthritis. Peritendinous or intrabursal corticosteroid injections can be used for the symptomatic treatment of greater trochanteric pain syndrome and anterior iliopsoas impingement. In past decades, the role of interventional radiology has rapidly increased in metastatic disease, thanks to the development of many ablative techniques. Image-guided percutaneous ablation of skeletal metastases provides a minimally invasive treatment option that appears to be a safe and effective palliative treatment for localized painful lytic lesion. Methods of tumour destruction based on temperature, such as radiofrequency ablation (RFA) and cryotherapy, are performed for the management of musculoskeletal metastases. MR-guided focused ultrasound surgery provides a non-invasive alternative to these ablative methods. Cementoplasty is now widely used for pain management and consolidation of acetabular metastases and can be combined with RFA. RFA is also used to treat benign tumours, namely osteoid osteomas. New interventional procedures such as percutaneous screw fixation are also proposed to treat non-displaced or minimally displaced acetabular roof fractures. INTRODUCTIONHip intra-articular injections have been used for many years as a diagnostic and/or therapeutic tool and even today remain an effective treatment for osteoarthritis providing pain relief. Ultrasound guidance can be used for injections in patients with greater trochanteric pain syndrome and CT scan guidance for corticosteroid injection in the management of anterior iliopsoas impingement after total hip arthroplasty. Interventional radiology plays a major role in the management of bone tumours. Several image-guided percutaneous ablation methods have proved effective for palliation of metastases involving bone and for the treatment of benign bone tumours, namely osteoid osteoma. To treat pain and consolidate the bone, cementoplasty could be required. In the therapeutic management of acetabular fractures, the combination of CT and fluoroscopy guidance could have a place in treating non-displaced or minimally displaced acetabular roof fractures.

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In Patients With Painful Hip Osteoarthritis, Is It More Beneficial to Offer Them an Ultrasound‐Guided or a Fluoroscopic‐Guided Intra‐Articular Corticosteroid Injection to Relieve Their Symptoms? A Systematic Review and Network Meta‐Analysis

Brookes,

Stynes

2024

Musculoskeletal Care

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PurposeHip osteoarthritis (OA) is a common disabling musculoskeletal condition. Clinical guidelines recommend intra‐articular corticosteroid injections (IACSI) as a pharmacological adjunct to help manage pain. IACSI are typically image‐guided either by ultrasound guidance (USG) or fluoroscopic guidance (FG) with no clear evidence towards the more efficacious guidance technique. This study aims to systematically review the scientific literature to determine the clinical effectiveness of USG compared with FG‐IACSIs for people with pain‐related hip OA.MethodsA systematic review of major bibliographic databases from inception to 24 August 2023 was conducted. Randomised controlled trials of USG‐ and FG‐IACSIs for patients with hip OA were included. The primary outcome measure was pain. Hedges' g calculated effect size and meta‐analysis using the random‐effects model‐estimated pooled effect sizes. τ2, I2 and Cochran's Q calculated heterogeneity. Network meta‐analysis was completed to indirectly compare effect sizes. Quality was assessed using the Cochrane risk‐of‐bias tool (RoB2).ResultsA total of 1464 citations were identified; eight studies were included in the review. No studies directly compared imaging modalities. Two network meta‐analyses indirectly comparing USG‐ to FG‐IACSI via an image‐guided comparator hip injection ([any comparator], [local anaesthetic or saline]) established effect sizes (g) of 2.61 and 2.46, respectively, both in favour of FG‐IACSI. Heterogeneity was low in the USG studies and high in the FG studies.Conclusion(s)Evidence suggests that both USG and FG‐IACSI are effective at reducing pain at 1 month in patients with painful hip OA. Although network meta‐analyses favoured FG‐IACSI, further high‐quality trials are needed to determine the preferred guidance technique.

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Hylan G-F 20 Improves Hip Osteoarthritis: A Prospective, Randomized Study

Cited by 42 publications

References 33 publications

Viscosupplementation for Osteoarthritis: a Primer for Primary Care Physicians

Viscosupplementation for Osteoarthritis: a Primer for Primary Care Physicians

Interventional MSK procedures: the hip

In Patients With Painful Hip Osteoarthritis, Is It More Beneficial to Offer Them an Ultrasound‐Guided or a Fluoroscopic‐Guided Intra‐Articular Corticosteroid Injection to Relieve Their Symptoms? A Systematic Review and Network Meta‐Analysis

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