Hyoscine N-Butylbromide for Preventing Propofol Injection Pain: A Randomized, Placebo-Controlled and Double-Blind Study

Sargın, Mehmet; Uluer, Mehmet Selçuk; Aydoğan, Eyüp

doi:10.1159/000486747

Cited by 6 publications

(7 citation statements)

References 27 publications

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“…HBB is also known as a semi‐synthetic derivative of scopolamine and is a quaternary ammonium compound (Shedid, 2012). HBB is an antagonist of muscarinic receptors in the smooth‐muscle cells of the visceral hollow organs (e.g., stomach, intestines, colon, gallbladder, bile ducts) and secretory glands (Samuels, 2009; Sargın, Uluer, & Aydoğan, 2018). HBB exerts anti‐cholinergic effects by inhibiting cholinergic transmission in the abdominal and pelvic parasympathetic ganglia and reduced motility in the gastrointestinal tract and urogenital ducts (Aggarwal, Zutshi, & Batra, 2008; Samuels, 2009).…”

Section: Introductionmentioning

confidence: 99%

Effect of buscopan, a compound that alleviates cramps, on the developing nervous system of the chick embryo

Ertekin

Atay

Bozkurt

et al. 2021

Birth Defects Research

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Background Buscopan is used to treat stomach cramps including those resulting from irritable bowel syndrome, bladder cramps, and pain related to menstruation. Its pregnancy category is determined as C. It has been shown in experimental animal studies that the drug has a negative effect on the embryo, but sufficient and well‐controlled studies have not been conducted in humans. The aim of this study is to investigate effects of buscopan on the development of the neural tube (NT) in chick embryos. Methods Sixty specific pathogen‐free (SPF) fertilized eggs were used. SPF eggs were placed in an incubator and divided into six groups at 28 hr of incubation. Five different doses (low to high) of buscopan were injected sub‐blastodermally. At the end of 48 hr, the embryos were evaluated morphologically and histopathologically. The argyrophilic nucleolar‐organizing region (AgNOR) method was used in this study to determine the proliferation activity of cells in NT development in chick embryos. AgNOR number and total AgNOR area/nuclear area (TAA/NA) were detected for each embryo. Results Depending on the dose, the embryo's crown‐rump length and somite number decreased (p < .05). Significant differences were detected among all groups for mean AgNOR number (p < .05) and TAA/NA ratio (p < .05). Conclusions Considering the average count of AgNOR cells and TAA/NA ratio, it was found that there was a decrease in cell division depending on the dose. It was determined that buscopan treatment on chick embryos adversely affected early nervous system and NT development.

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Section: Introductionmentioning

confidence: 99%

Effect of buscopan, a compound that alleviates cramps, on the developing nervous system of the chick embryo

Ertekin

Atay

Bozkurt

et al. 2021

Birth Defects Research

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“…However, pain with its injection has been identified as a troubling experience for patients. About 28-90% of patients receiving propofol injection via the dorsal hand vein suffer different levels of pain intensity (3,4). In addition, many anesthesiologists rank the pain experienced during propofol injection pain as the seventh-worst outcome among 33 known anesthesia outcomes, based on clinical importance and frequency (5).…”

Section: Introductionmentioning

confidence: 99%

“…Compared to lidocaine used alone, combination therapy is recommended in clinical situations (3). Therefore, the purpose of our study was to explore the effect of intravenous Dex-prior to anesthesia induction with propofol at 4 • C in attenuating propofol injection pain compared with lidocaine applied independently.…”

Section: Introductionmentioning

confidence: 99%

Intravenous Dexmedetomidine Administration Prior Anesthesia Induction With Propofol at 4°C Attenuates Propofol Injection Pain: A Double-Blind, Randomized, Placebo-Controlled Trial

Liu³

et al. 2021

Front. Med.

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Background: Propofol injection pain, despite various interventions, still occurs during the anesthesia induction and causes intense discomfort and anxiety in patients. This study aimed to explore the effect of intravenous dexmedetomidine on propofol injection pain prior to anesthesia induction with propofol at 4°C.Methods: A total of 251 patients (American Society of Anesthesiologists I–II) who underwent oral and maxillofacial surgery were randomly assigned to a combination group (n = 63), lidocaine group (n = 62), dexmedetomidine group (n = 63), and placebo-control group (n = 63); they received 0.5 ug/kg dexmedetomidine prior to anesthesia induction with propofol at 4°C, 40 mg lidocaine, 0.5 ug/kg dexmedetomidine prior to anesthesia induction, and normal saline, respectively. Incidence of pain, pain intensity, and reaction to the pain stimulus were evaluated by using verbal categorial scoring (VCS), a numerical rating scale (NRS), and the Surgical Pleth Index (SPI), respectively. In addition, hemodynamic parameters such as heart rate (HR) and mean arterial pressure (MAP) were also measured. The VCS and NRS were evaluated at 5 s after propofol injection. In addition, SPI, HR, and MAP were evaluated at three time points (before anesthesia induction and 5 and 30 s after propofol injection).Results: The incidence of pain in the combination group (51%) was significantly lower than that in the lidocaine group (71%), dexmedetomidine group (67%), or placebo-control group (94%) (p < 0.001). VCS and NRS scores in the combination group were also lower compared with the other three groups (p < 0.001), with no statistically significant differences between the lidocaine group and dexmedetomidine group (p > 0.05). The SPI of the combination group decreased significantly in comparison with the other three groups at 5 s after propofol injection (F = 96.23, p < 0.001) and 30 s after propofol injection (F = 4.46, p = 0.005). Further comparisons between HR and MAP revealed no significant differences across the groups (p > 0.05).Conclusion: Because of the sedative nature of dexmedetomidine and analgesic effect of low temperature, this study showed that intravenous dexmedetomidine prior to anesthesia induction with propofol at 4°C is highly effective in attenuating the incidence and severity of pain during injection compared with lidocaine (40 mg), dexmedetomidine 0.5 ug/kg) and placebo. This approach was not associated with any anesthesia complications.Clinical Trial Registration:ClinicalTrials.gov, identifier: ChiCTR-2000034663

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“…Previous studies have assessed various methods to alleviate PIP, including changing the injection speed, warming up propofol, choosing a large vein and the addition of some drugs [5][6][7][8][9][10][11][12][13]. At present, lidocaine is the most common drug used to relieve PIP.…”

Section: Introductionmentioning

confidence: 99%

Comparing the effects of dezocine with lidocaine on prevention of propofol injection pain in adults: a prospective randomized double-blind trial

Zhu

Jia

et al. 2019

Preprint

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Background Propofol injection pain (PIP) is common and may decrease patient comfort. The aim of this study was to compare the effects of dezocine with lidocaine on prevention of PIP.Methods 235 patients, who scheduled for elective surgery, aged 18–80 years and American Society of Anesthesiologists (ASA) I or II, were randomly assigned into five groups (n = 47 each). All patients were induced through the dorsal hand vein or antecubital vein. The five groups were given the following medication intravenously: saline (Group I), lidocaine 20 mg (Group II), lidocaine 40 mg (Group III), dezocine 2 mg (Group IV) and dezocine 4 mg (Group V). Twenty seconds later all patients received a propofol infusion and were asked to grade pain or discomfort in the hand or forearm according to a four-point scale until anesthesia.Results Three groups showed a significantly lower incidence of total PIP than Group I: Group III (OR [Odds ratio]: 0.39 (0.16, 0.93)); Group IV (OR: 0.21 (0.09, 0.51)) and Group V (OR: 0.12 (0.05, 0.30)). Group IV showed a significantly lower incidence of total PIP than Group II (OR: 0.32 (0.13, 0.77)). Group V showed a significantly lower incidence of total PIP than Group II (OR: 0.15 (0.06, 0.39)) or Group III (OR: 0.30 (0.13, 0.72)).Conclusion Dezocine is a novel agent to alleviate PIP and appears to some extent to be more effective than lidocaine.

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Hyoscine N-Butylbromide for Preventing Propofol Injection Pain: A Randomized, Placebo-Controlled and Double-Blind Study

Cited by 6 publications

References 27 publications

Effect of buscopan, a compound that alleviates cramps, on the developing nervous system of the chick embryo

Effect of buscopan, a compound that alleviates cramps, on the developing nervous system of the chick embryo

Intravenous Dexmedetomidine Administration Prior Anesthesia Induction With Propofol at 4°C Attenuates Propofol Injection Pain: A Double-Blind, Randomized, Placebo-Controlled Trial

Comparing the effects of dezocine with lidocaine on prevention of propofol injection pain in adults: a prospective randomized double-blind trial

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