Hyper-homocysteinemia Inducing Hyperuricemia: What are the Mechanisms?

Cacciapuoti, Federico

doi:10.4078/jrd.2017.24.3.127

Cited by 4 publications

(8 citation statements)

References 25 publications

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“…Hypertension was equally distributed between males and females (65% [16] and 75% [9] , respectively). The prevalence of smoking was 46% [17] ; with 55% [18] and 17% [2] in males and females, respectively. Further analyses revealed lower HCY level in males (12.99±4.22 µmol/L) compared to females (16.94±5.30 µmol/L) (p=0.042).…”

Section: Resultsmentioning

confidence: 94%

“…Contradictory results may be due to different selection of research participants, i.e. different inclusion and exclusion criteria in the study, different number of participants, methods used, genetic basis and different eating habits [17] . Genetic basis, sufficient intake of vitamins B6, B12 and folic acid, as well as preserved renal function, are factors that directly affect HCY level [11] and should all be considered during assessment in any case.…”

Section: Discussionmentioning

confidence: 99%

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A relation of serum homocysteine and uric acid in Bosnian diabetic patients with acute myocardial infarction

Marković-Boras¹,

Čaušević²,

Ćurlin³

2021

J Med Biochemistry

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Background Coronary artery disease as a consequence of atherosclerosis is the most common cause of morbidity and mortality in type 2 Diabetes Mellitus (DM) patients. Homocysteine (HCY), as one of the risk factors, and uric acid (UA) as the most common antioxidant in serum have their roles in the processes of inflammation and atherogenesis, which underlie the pathogenesis of acute myocardial infarction (AMI). The effect of HCY in cardiovascular disease is thought to manifest primarily through oxidative damage, impling potential correlation between the HCY level and antioxidant status. Since the data related to diagnostic significance of both HCY and UA in diabetic patients with AMI are conflicting, and so far not reported in Bosnian patients, the aim of this research was to examine the association of HCY and UA levels with glomerular filtration rate (eGFR) and explore the pathophysiological significance of these data in Bosnian diabetic patients with AMI. Methods This prospective research included 52 DM type 2 patients diagnosed with AMI. Blood samples were taken on admission, and used for biochemical analysis. Results of the biochemical analyses were statistically analyzed. Results Elevated HCY and UA levels were observed in diabetic patients. Females have higher HCY compared to males. Positive correlation was revealed between HCY and UA and was confirmed with different HCY levels in subgroups with different UA level. Negative correlation was observed between UA and HbA1c, as well as between both HCY and UA with eGFR. Conclusions These results contribute to clarification of the biochemical mechanisms characteristic in AMI patients with DM. According to these results, we believe that joint measurement of HCY and UA could enable a better assessment of the prognosis for this group of patients. This kind of assessment, as well as regression analysis can identify high-risk patients at an earlier stage, when appropriate interventions can influence a better outcome in such patients.

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Section: Resultsmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

A relation of serum homocysteine and uric acid in Bosnian diabetic patients with acute myocardial infarction

Marković-Boras¹,

Čaušević²,

Ćurlin³

2021

J Med Biochemistry

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“…The connection between hyperhomocysteinemia and uric acid is explained by the methioninehomocysteine cycle [25]. In this cycle, methionine is converted to S-adenosyl-homocysteine (SAH), which becomes Hcy and adenosine, with adenosine then being degraded to uric acid.…”

Section: Discussionmentioning

confidence: 99%

Hyperhomocysteinemia in association with male gender, advanced age, uric acid and metabolic syndrome: A retrospective cross-sectional study

Chen

Wang

et al. 2019

Preprint

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Background Elevated homocysteine level has been proposed as a risk factor for cardiovascular disease. The aim of this study is to evaluate the connection between hyperhomocysteinemia with other factors for early detection of possible cardiovascular disease. Methods The data in this retrospectively designed cross-sectional study was retrieved from the health examination database in a medical center located in southern Taiwan in 2016. The correlation of hyperhomocysteinemia with sex, age, body mass index, waist circumference, lipid profile, blood pressure, uric acid, high sensitivity C-reactive protein and lipoprotein were investigated. Both simple and multiple stepwise logistic regression models were used for the assessment of their connection. Results A total of 878 subjects with mean age of 55.4 ± 10.8 years were included in the current study and 73 (9.1%) participants had elevated homocysteine levels. Simple logistic regression analysis showed elevated Hcy was significantly associated with sex (OR 0.11, 95% CI 0.04-0.31, P < 0.001), age (OR 1.03, 95% CI 1.00-1.05, P < 0.035), waist circumference (OR 1.04, 95% CI 1.02-1.06, P = 0.001), HDL-C (OR 0.97, CI 0.95-0.99, P = 0.011), triglyceride (OR 1.00, CI 1.00-1.01, P = 0.002), SBP (OR 1.02, CI 1.01-1.03, P = 0.004), DBP (OR 1.04, CI 1.02-1.06, P = 0.001), sugar level (OR 1.01, CI 1.00-1.02, P = 0.021), uric acid (OR 1.39, CI 1.20-1.60, P < 0.001) and the presence of metabolic syndrome (OR 1.81, CI 1.12-2.93, P = 0.016). Multiple stepwise logistic regression analysis was applied and the result showed that male gender (OR 0.15, 95% CI 0.05-0.43, P < 0.001), advanced age (OR 1.03, 95% CI 1.00-1.05, P < 0.036), triglycerides (OR 1.002, 95% CI 1.001-1.004, P = 0.022), systolic blood pressure (OR 1.02, 95% CI 1.00-1.03, P = 0.023) and uric acid (OR 1.26, 95% CI 1.07-1.47, P = 0.005) were significantly associated with the elevation of plasma homocysteine. Conclusions Several factors are associated with hyperhomocysteinemia in asymptomatic subjects including sex, age, uric acid and metabolic syndrome components. Among these factors, male, advanced age, systolic blood pressure, plasma level of triglyceride and uric acid were independently associated with hyperhomocysteinemia.

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“…1 Uric acid is the end product of purine metabolism and it has been considered protective against oxidative stress acting as an antioxidant. 3,4 A possible association between serum uric acid level and bone metabolism has been suggested. 3,4 A possible association between serum uric acid level and bone metabolism has been suggested.…”

Section: Introductionmentioning

confidence: 99%

“…2 It has been demonstrated that uric acid level and gout are risk factors for certain conditions or act as protective factors against various medical conditions. 3,4 A possible association between serum uric acid level and bone metabolism has been suggested. 5 A meta-analysis showed that subjects with higher serum uric acid levels had significantly higher bone mineral density (BMD) values for the spine and femur neck (FN).…”

Section: Introductionmentioning

confidence: 99%

Uric acid level, gout and bone mineral density: A Mendelian randomization study

Lee

Song

2019

Eur J Clin Investigation

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Objective: This study aimed to examine whether the uric acid level or gout is causally associated with bone mineral density (BMD). Method: We performed a two-sample Mendelian randomization (MR) analysis. The statistics dataset, we used was from a meta-analysis of genome-wide association studies (GWASs) on uric acid levels from 14 studies with a total of 28 141 participants of European descent, and the dataset for gout from the United Kingdom (UK)Biobank (4807 cases and 3 32 352 controls). We further used the summary statistics dataset of a GWAS on lumbar spine and femur neck (FN) BMDs of individuals of European ancestry (up to 32 735). Results: The instrumental variables (IVs) selected were six single nucleotide polymorphisms (SNPs) from the uric acid level GWAS data and 19 SNPs from the gout GWAS data. The inverse-variance weighted (IVW) method yielded no evidence to support a causal association between the uric acid level or gout and lumbar spine BMD (β = −.002, standard error (SE) = 0.035, P = .951; β = -.700, SE = 0.672, P = .297). MR-Egger regression revealed no causality between uric acid level, gout and lumbar spine. Similarly, the weighted median approach provided no evidence of causality between uric acid level, gout and lumbar spine BMD. The MR results on FN BMD showed similar patterns with those of the lumbar spine BMD. Conclusions: Mendelian randomization analysis did not support a causal association between uric acid level, gout and lumbar spine or FN BMD. K E Y W O R D S BMD, gout, Mendelian randomization, uric acid level

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Hyper-homocysteinemia Inducing Hyperuricemia: What are the Mechanisms?

Cited by 4 publications

References 25 publications

A relation of serum homocysteine and uric acid in Bosnian diabetic patients with acute myocardial infarction

A relation of serum homocysteine and uric acid in Bosnian diabetic patients with acute myocardial infarction

Hyperhomocysteinemia in association with male gender, advanced age, uric acid and metabolic syndrome: A retrospective cross-sectional study

Uric acid level, gout and bone mineral density: A Mendelian randomization study

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