Hyper-homocysteinemia is Not a Main Feature of Juvenile Uncomplicated Type 1 Diabetes

Abstract

Total plasma homocysteine (tHcy) was measured by high pressure liquid chromatography (HPLC) method in 28 patients (12 females and 16 males) at the onset of type 1 diabetes mellitus (T1DM), 4 females during diabetes ketoacidosis (DKA) and 154 (68 females and 86 males) during follow-up. Serum folate, pyridoxal 5' phosphate (PLP) and Vitamin B12 (Vit B12) were also measured. Plasma tHcy levels were not found significantly different in T1DM patients known to have diabetes (males 9.2

Plasma total homocysteine and carotid intima-media thickness in type 1 diabetes: A prospective study

“…Hyperhomocysteinemia is typically defined as levels >10μmol/L in reported studies [25], [26] and [27]. Levels of tHcy measured in our DCCT/EDIC cohort are comparable to observed tHcy concentrations in other studies of T1DM of similar time frame and/or participant characteristics [3], [6], [28] and [29]. While we lacked a non-diabetic control group, the observed tHcy levels in our cohort are also similar or lower than in other studies of apparently healthy non-diabetic subjects [30], and may reflect healthy dietary habits among our study participants, and for some (46%), the use of multivitamins (likely to contain tHcy-lowering B-group vitamins).…”

Elevated plasma adiponectin and decreased plasma homocysteine and asymmetric dimethylarginine in children with type 1 diabetes

“…A link between plasma hyperhomocysteinemia and nephropathy in patients with both type 1 and type 2 diabetes has been reported [20,21]. However, reduced tHcy concentrations have been found in children and adults without diabetic nephropathy [22][23][24]. In our study, children with diabetes had significantly lower tHcy levels than the controls.…”

Evaluation of chemiluminescence method for the analysis of plasma homocysteine and comparison with HPLC method in children samples

“…5 PhD; Assistant Professor at Department of Biochemistry of Faculdade de Medicina do ABC -FMABC, Santo André (SP), Brazil. 6 PhD; Professor at Department of Pediatrics of Faculdade de Medicina do ABC -FMABC, Santo André (SP), Brazil. 7 Medical student at Faculdade de Medicina do ABC -FMABC, Santo André (SP), Brazil.…”

“…Several diseases and situations have been associated with higher levels of homocysteine, for example chronic heart failure (3) , effects of vascular diseases (4) besides oxidative stress (5) , type 1 diabetes (6) , obesity (7) and homocystinuria (8) . However, it is not very safe to say if these changes are the cause or the consequences of primary diseases.…”