2020
DOI: 10.1186/s12915-020-00883-4
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Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2

Abstract: Background Wnt signaling is a critical determinant for the maintenance and differentiation of stem/progenitor cells, including trophoblast stem cells during placental development. Hyperactivation of Wnt signaling has been shown to be associated with human trophoblast diseases. However, little is known about the impact and underlying mechanisms of excessive Wnt signaling during placental trophoblast development. Results In the present… Show more

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Cited by 15 publications
(16 citation statements)
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“…Moreover, studies have shown that SFRP5 is highly expressed in mouse extraembryonic trophoblasts and participates in the differentiation of early placental trophoblast giant cells and spongiotrophoblast cells. In fact, there are some genetic and functional differences between mouse and human placentas [47]. It is important to explore the differences in SFRP5 in mouse and human placentas in future studies.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, studies have shown that SFRP5 is highly expressed in mouse extraembryonic trophoblasts and participates in the differentiation of early placental trophoblast giant cells and spongiotrophoblast cells. In fact, there are some genetic and functional differences between mouse and human placentas [47]. It is important to explore the differences in SFRP5 in mouse and human placentas in future studies.…”
Section: Discussionmentioning
confidence: 99%
“…37,38 To observe the effect of TBT on placental development, we firstly examined the growth of ectoplacental cone at pregnant days 8, which is the precursor of placental tissue and will develop into placental spongiotrophoblast layer at pregnant days 13. 39 Our results showed that TBT exposure significantly inhibited the growth of ectoplacental cone, and reduced placental weight and attenuated the areas of total placenta, spongiotrophoblast and labyrinth. Therefore, it was speculated that the poor reproductive performance of TBT exposure including an increase of resorbed embryo and a reduction of fetal weight was indeed due to developmental disorders of the placenta.…”
Section: Discussionmentioning
confidence: 49%
“…Placenta is a unique organ of mammals during pregnancy, which can provide cell matrix, hormone, growth factor, sufficient blood supply and nutrients for fetal development 37,38 . To observe the effect of TBT on placental development, we firstly examined the growth of ectoplacental cone at pregnant days 8, which is the precursor of placental tissue and will develop into placental spongiotrophoblast layer at pregnant days 13 39 . Our results showed that TBT exposure significantly inhibited the growth of ectoplacental cone, and reduced placental weight and attenuated the areas of total placenta, spongiotrophoblast and labyrinth.…”
Section: Discussionmentioning
confidence: 99%
“…The importance of this fine tuning has also been documented by other authors; co-culture models have revealed that the interaction between trophoblast and decidua results in downregulation of Wnt components (including Wnt4) through paracrine signaling [ 30 , 58 , 59 ] and that downregulation of certain Wnt components may be essential for normal pregnancy progression [ 60 ]. A recent study by Bao et al (2020) [ 26 ] documented that hyperactivation of Wnt signaling in the mouse model disrupted trophoblast differentiation. The authors observed that two inhibitors of Wnt signaling (sFRPs1 and 5) are highly expressed in extraembryonic trophoblast.…”
Section: Discussionmentioning
confidence: 99%
“…Wnt/β-catenin silencing has been shown to block the ability of the blastocyst to implant [ 25 ]. Interestingly, Bao et al (2020) recently showed that over-expression of the Wnt-β-catenin signaling, through silencing of Wnt inhibitors, is also detrimental for trophoblast differentiation [ 26 ].…”
Section: Introductionmentioning
confidence: 99%