Hyperactivity in the rat is associated with spontaneous low level of n-3 polyunsaturated fatty acids in the frontal cortex

Involvement of omega-3 fatty acids in emotional responses and hyperactive symptoms☆

“…Likewise, spontaneously hypertensive rats exhibit locomotor hyperactive symptoms and low DHA in their plasma and brain membranes [44,45]. In line with these results, we have shown that impulsiveness and high locomotor responses to novelty were associated with low DHA levels in rats fed a normal diet [46]. Although some studies found no influence of reduced dietary n-3 PUFA intake on locomotion, all these observations are consistent with the potential involvement of altered brain DHA content in the manifestation of hyperactive symptoms.…”

Incorporation of n-3 fatty acids by the liver of mice fed linseed oil as a function of feeding duration

“…The intake of n-3 polyunsaturated fatty acids (PUFA) (from linseed oil or marine oils) partially replaces the 20:4n-6 in the eicosanoid metabolism, favoring the less inflammatory and aggregatory 3-series prostanoids and 5-series leukotrienes (Surette, 2008). The competition between n-6 and n-3 FA may be clinically important and may affect the development or progression of diseases (Vancassel et al, 2007). It is worth nothing that AA is important for fetal growth and the metabolism of prostaglandins (Calder, 2006;Innis, 2007), while among LC-PUFA, EPA and DHA have received much attention from the scientific communities because of their positive role in human health (Carl et al, 2009;Calder, 2006;Chapkin et al, 2009).…”

n-3 Polyunsaturated fatty acid supplementation reverses stress-induced modifications on brain monoamine levels in mice

“…3). Moreover, rodents subjected to diets deficient in DHA or its precursor show reduced attention and reduction in locomotor responses to novelty, habituation, and anxiety (4)(5)(6). n-3 PUFA-deficient animals also exhibit aggressive behavior and increased symptoms of depression in a forced swim test (7).…”