Hyperadiponectinemia Is Independent of Kidney Function, Diabetes Duration, and Control in Type 1 Diabetic Patients without Microangiopathy

Khalil, Charbel Abi; Mohammedi, Kamel; Aubert, Roberte; Jaoude, Elizabeth Abou; Travert, F.; Hadjadj, Samy; Fumeron, Frédéric; Roussel, Ronan; Marre, Michel

doi:10.1210/jc.2010-1835

Cited by 6 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding may be explained by the greater stability of HbA1c level, which is also independent from transient confounders, as postprandial state, which significantly affect random glucose level. Similar association between elevated serum adiponectin concentration and HbA1c or hyperglycemia has been reported in other studies [ 1 ], although not equivocally [ 3 ]. Higher serum adiponectin concentration in patients with diabetic ketoacidosis at onset of T1DM may be attributed to the rise of adiponectin in conditions associated with increased catabolism and cachexia.…”

Section: Discussionsupporting

confidence: 88%

Association between serum adiponectin and HbA1c is independent of the severity of clinical presentation in young adults with new onset type 1 diabetes

Piłaciński

Wierusz‐Wysocka

Zozulińska−Ziółkiewicz

2016

J Endocrinol Invest

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 88%

Association between serum adiponectin and HbA1c is independent of the severity of clinical presentation in young adults with new onset type 1 diabetes

Piłaciński

Wierusz‐Wysocka

Zozulińska−Ziółkiewicz

2016

J Endocrinol Invest

View full text Add to dashboard Cite

“…12,14 In the FinnDiane study, Forsblom et al 13 demonstrated that high adiponectin levels were associated with 11-year risk of all-cause and cardiovascular mortality in a nationwide multicenter cohort of Finnish adults with T1DM. Hypotheses to explain elevated adiponectin levels in patients with T1DM include a compensatory response to vascular injury, 24 decreased clearance due to renal insufficiency, 14 effects of subcutaneous insulin treatment, 25 and posttranslational modifications (glycosylation) that could occur in persons with T1DM.…”

Section: Discussionmentioning

confidence: 99%

Serum Adiponectin Helps to Differentiate Type 1 and Type 2 Diabetes Among Young Asian Indians

Gokulakrishnan

Aravindhan

Amutha

et al. 2013

Diabetes Technology & Therapeutics

View full text Add to dashboard Cite

Objective: This study assessed whether serum adiponectin could be used as a biochemical marker to differentiate type 1 diabetes mellitus (T1DM) from type 2 diabetes mellitus (T2DM) among young Asian Indians. Research Design and Methods: We recruited age-and sex-matched individuals with physician-diagnosed T1DM (n = 70) and T2DM (n = 72). All were 12-27 years of age with a duration of diabetes of >2 years, at a large tertiary-care diabetes center in Chennai, southern India. Age-and sex-matched individuals with normal glucose tolerance (NGT) (n = 68) were selected from an ongoing population study. NGT was defined using World Health Organization criteria. Serum total adiponectin was measured by enzyme-linked immunosorbent assay. Receiver operating characteristic (ROC) curves were used to identify adiponectin cut points for discriminating T1DM from T2DM. Results: Adiponectin levels were higher in T1DM and lower in T2DM compared with the NGT group (9.89, 3.88, and 6.84 lg/ mL, respectively; P < 0.001). In standardized polytomous regression models, adiponectin was associated with T1DM (odds ratio [OR] = 1.131 per SD; 95% confidence interval [CI], 1.025-1.249) and T2DM (OR = 0.628 per SD; 95% CI, 0.504-0.721) controlled for age, gender, waist circumference, body mass index, hypertension, glycated hemoglobin, total cholesterol, serum triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, family history of T2DM, and estimated glomerular filtration rate. Using ROC analysis, an adiponectin cut point of 5.1 lg/mL had a C statistic of 0.886 (95% CI, 0.836-0.953), sensitivity of 80.6%, and specificity of 80.6% to differentiate T1DM from T2DM. Using the 5.1 lg/mL cut point, 80.6% of T1DM and 81.8% of T2DM would be correctly classified. Conclusions: Serum adiponectin is a useful biochemical marker for differentiating T1DM and T2DM among young Asian Indians.

show abstract

“…Total and high-molecular-weight adiponectin levels are elevated in the serum of T1D patients, but there are lower levels of adiponectin receptor expression on monocytes and antigen-presenting cells, which may be responsible for increased inflammation. [1][2][3][4][5] In contrast, lower serum levels of adiponectin are associated with T2D, cardiovascular disease, and insulin resistance, although the levels increase when T2D patients undergo post-gastric bypass surgery for visceral fat reduction. 6,7 The downregulation of adiponectin receptor expression in T1D patients is associated with the proliferation of primary CD4 + T-cells in the presence of islet lysate independent of adiponectin treatment, whereas healthy control T-cells are inhibited by adiponectin.…”

Section: Introductionmentioning

confidence: 99%

Adiponectin Receptor Fragmentation in Mouse Models of Type 1 and Type 2 Diabetes

Pugia

Frabutt

Stull

et al. 2019

Preprint

View full text Add to dashboard Cite

The protein hormone adiponectin regulates glucose and fatty acid metabolism by binding to two PAQR-family receptors (AdipoR1 and AdipoR2). Both receptors feature a C-terminal segment which is released by proteolysis to form a freely-circulating C-terminal fragment (CTF) found in the plasma of normal individuals but not in some undefined diabetes patients. The AdipoR1-CTF344-376 is a competitive inhibitor of tumor necrosis factor α cleavage enzyme (TACE) but it contains a shorter peptide domain (AdipoR1 CTF351-362) that is a strong non-competitive inhibitor of insulin-degrading enzyme (IDE). The link between adiponectin receptor fragmentation and diabetes pathology is unclear but could lead to new therapeutic strategies. We therefore investigated physiological variations in the concentrations of CTF in non-obese diabetic (NOD/ShiLtJ) mice and C57BL/6 mice with diet-induced obesity (DIO) as models of diabetes types 1 and 2, respectively. We tested for changes in adiponectin receptor signaling, immune responses, disease progression, and the abundance of neutralizing autoantibodies. Finally, we administered exogenous AdipoR1-CTF peptides either containing or lacking the IDE-binding domain. We observed the more pronounced CTF shedding in the TACE-active NOD mice, which represents an inflammatory autoimmune phenotype, but fragmentation was also observed to a lesser extent in the DIO model. Autoantibodies to CTF were detected in both models. Neither exogenous CTF peptide affected IgG-CTF plasma levels, body weight or the conversion of NOD mice to diabetes. The pattern of AdipoR1 fragmentation and autoantibody production under physiological conditions of aging, DIO, and autoimmune diabetes therefore provides insight into the association adiponectin biology and diabetes.

show abstract

Hyperadiponectinemia Is Independent of Kidney Function, Diabetes Duration, and Control in Type 1 Diabetic Patients without Microangiopathy

Abstract: In T1D without microangiopathy, high ADPN levels could not be related to anthropometric diabetes parameters, kidney function, or high insulin levels. The nature of this elevation remains unknown.

Cited by 6 publications

References 14 publications

Association between serum adiponectin and HbA1c is independent of the severity of clinical presentation in young adults with new onset type 1 diabetes

Association between serum adiponectin and HbA1c is independent of the severity of clinical presentation in young adults with new onset type 1 diabetes

Serum Adiponectin Helps to Differentiate Type 1 and Type 2 Diabetes Among Young Asian Indians

Adiponectin Receptor Fragmentation in Mouse Models of Type 1 and Type 2 Diabetes

Contact Info

Product

Resources

About