Hyperbaric oxygen and aerobic exercise in the long-term treatment of fibromyalgia: A narrative review

El-Shewy, Kholoud M.; Kunbaz, Ahmad; Gad, Mohamed M.; Al‐Husseini, Muneer J.; Saad, Anas M.; Sammour, Yasser; Abdel-Daim, Mohamed M.

doi:10.1016/j.biopha.2018.10.157

Cited by 18 publications

(20 citation statements)

References 93 publications

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“…23 In addition, HBOT stimulates nitric oxide synthesis, which helps to alleviate hyperalgesia and NO-dependent release of endogenous opioids which has been proposed to be the primary HBOT mechanism of antinociception. 54 This decrease in pain is in line with Yildiz’s study, 26 which used a similar treatment protocol, although with greater pressure than that applied in our study and which obtained significant improvements for pain scores in as much as 3.31 points. This confirms that, although the pressure applied in our study is lower than that used to date, which could avoid the aforementioned complications, it is sufficient to significantly reduce pain, with a result that exceeds 1 cm considered the minimum clinically relevant change.…”

Section: Discussionsupporting

confidence: 91%

Comparative study of the effectiveness of a low-pressure hyperbaric oxygen treatment and physical exercise in women with fibromyalgia: randomized clinical trial

Izquierdo-Alventosa

Inglés

Cortés‐Amador

et al. 2020

Therapeutic Advances in Musculoskeletal

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Background: Fibromyalgia (FM) is characterized by chronic pain and fatigue, among other manifestations, thus advising interventions that do not aggravate these symptoms. The main purpose of this study is to analyse the effect of low-pressure hyperbaric oxygen therapy (HBOT) on induced fatigue, pain, endurance and functional capacity, physical performance and cortical excitability when compared with a physical exercise program in women with FM. Methods: A total of 49 women with FM took part in this randomized controlled trial. They were randomly allocated to three groups: physical exercise group (PEG, n = 16), low-pressure hyperbaric oxygen therapy group (HBG, n = 17) and control group (CG, n = 16). Induced fatigue, perceived pain, pressure pain threshold, endurance and functional capacity, physical performance and cortical excitability were assessed. To analyse the effect of the interventions, two assessments, that is, pre and post intervention, were carried out. Analyses of the data were performed using two-way mixed multivariate analysis of variance. Results: The perceived pain and induced fatigue significantly improved only in the HBG ( p < 0.05) as opposed to PEG and CG. Pressure pain threshold, endurance and functional capacity, and physical performance significantly improved for both interventions ( p < 0.05). The cortical excitability (measured with the resting motor threshold) did not improve in any of the treatments ( p > 0.05). Conclusions: Low-pressure HBOT and physical exercise improve pressure pain threshold, endurance and functional capacity, as well as physical performance. Induced fatigue and perceived pain at rest significantly improved only with low-pressure HBOT. Trial registration: ClinicalTrials.gov identifier NCT03801109.

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Section: Discussionsupporting

confidence: 91%

Comparative study of the effectiveness of a low-pressure hyperbaric oxygen treatment and physical exercise in women with fibromyalgia: randomized clinical trial

Izquierdo-Alventosa

Inglés

Cortés‐Amador

et al. 2020

Therapeutic Advances in Musculoskeletal

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“…Therefore, the increased oxygen concentration caused by HBOT is supposed to change the brain metabolism and glial function with a potential effect on reducing the FM-associated brain abnormal activity [ 132 ]. HBOT was found to affect the mitochondrial mechanisms resulting in functional brain changes, stimulate nitric oxide production thus alleviating hyperalgesia and promoting the NO-dependent release of endogenous opioids which appear to be involved in the antinociception prompted by HBOT [ 133 ]. In a clinical study, a significant difference between the HBOT and control groups was found in the reduction in tender points and VAS scores after the first and fifteenth therapy sessions [ 130 ].…”

Section: Therapymentioning

confidence: 99%

Fibromyalgia: Recent Advances in Diagnosis, Classification, Pharmacotherapy and Alternative Remedies

Maffei

2020

IJMS

105

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Fibromyalgia (FM) is a syndrome that does not present a well-defined underlying organic disease. FM is a condition which has been associated with diseases such as infections, diabetes, psychiatric or neurological disorders, rheumatic pathologies, and is a disorder that rather than diagnosis of exclusion requires positive diagnosis. A multidimensional approach is required for the management of FM, including pain management, pharmacological therapies, behavioral therapy, patient education, and exercise. The purpose of this review is to summarize the recent advances in classification criteria and diagnostic criteria for FM as well as to explore pharmacotherapy and the use of alternative therapies including the use of plant bioactive molecules.

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“…The Role of Vitamin D in the Management of Chronic Pain in Fibromyalgia: A Narrative Review Health Psychology Research traction as an alternative therapy due to the multitude of physiological mechanisms by which it diminishes nociception. 59 Specifically, HBOT targets a variety of the underlying pathophysiological processes that result in FM's chronic pain state, including reduced production of glial cells and inflammatory mediators. 59 Additionally, nutritional supplementation in the form of vitamins has gained popularity in pain management, especially vitamin D. However, the evidence regarding the efficacy of vitamins as a therapeutic adjunct remains inconclusive and requires further study.…”

Section: Pathophysiology-sleep Qualitymentioning

confidence: 99%

“…59 Specifically, HBOT targets a variety of the underlying pathophysiological processes that result in FM's chronic pain state, including reduced production of glial cells and inflammatory mediators. 59 Additionally, nutritional supplementation in the form of vitamins has gained popularity in pain management, especially vitamin D. However, the evidence regarding the efficacy of vitamins as a therapeutic adjunct remains inconclusive and requires further study. 42,60,61 Note that the effectiveness of these therapeutic approaches are not equal, and there are varying levels of evidence to support their use.…”

Section: Pathophysiology-sleep Qualitymentioning

confidence: 99%

The Role of Vitamin D in the Management of Chronic Pain in Fibromyalgia: A Narrative Review

Haddad

Jumonville

Stark

et al. 2021

Health Psychology Research

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Health Psychology Research ConclusionExisting studies provide promising results. However, additional high-quality data on vitamin D supplementation is needed before recommendations for pain management can be made. Vitamin D supplementation is inexpensive, has minimal side effects, and can benefit FM patients regardless of its efficacy in pain control. Additionally, high-quality studies are warranted to fully elucidate the potential of vitamin D to manage chronic pain in FM.

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Hyperbaric oxygen and aerobic exercise in the long-term treatment of fibromyalgia: A narrative review

Cited by 18 publications

References 93 publications

Comparative study of the effectiveness of a low-pressure hyperbaric oxygen treatment and physical exercise in women with fibromyalgia: randomized clinical trial

Comparative study of the effectiveness of a low-pressure hyperbaric oxygen treatment and physical exercise in women with fibromyalgia: randomized clinical trial

Fibromyalgia: Recent Advances in Diagnosis, Classification, Pharmacotherapy and Alternative Remedies

The Role of Vitamin D in the Management of Chronic Pain in Fibromyalgia: A Narrative Review

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