Hyperbaric oxygen and wound healing

Zamboni, William A.; Browder, Leslie K.; Martinez, John

doi:10.1016/s0094-1298(02)00068-8

Cited by 61 publications

(42 citation statements)

References 6 publications

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“…At the same time, vascular compromise and loss of blood flow disable the tissue from eliminating metabolites, such as lactic acid, from the wound. 29 Lactic acid, a byproduct of anaerobic metabolism, accumulates and acidifies the wound environment, which may lead to cell death. Long-term hypoxia and loss of the ability for cells to adapt to hypoxia lead to impaired and pathologic wound healing.…”

Section: Commentmentioning

confidence: 99%

Topical Oxygen Emulsion

Davis¹,

Cazzaniga

Ricotti

et al. 2007

Arch Dermatol

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Section: Commentmentioning

confidence: 99%

Topical Oxygen Emulsion

Davis¹,

Cazzaniga

Ricotti

et al. 2007

Arch Dermatol

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“…[1][2][3][4] Hyperoxia during HBOT is an important mediating factor for wound collagen deposition and cross-linking, 5 neutrophil-dependent microbial killing, 6 and neovascularization. 7 Other HBOT-mediated processes in wound healing include the inhibition of integrin-mediated intravascular leukocyte adhesions and platelet aggregation, 8 enhancement of cutaneous microvascular homeostasis after ischemia-reperfusion syndrome, 9 increased oxygen capacitance and survival of ischemic flaps, 10 and upregulation of platelet-derived growth factor (PDGF) receptor mRNA.…”

mentioning

confidence: 99%

Hyperbaric Oxygen Therapy Mediates Increased Nitric Oxide Production Associated With Wound Healing

Boykin

Baylis

2007

Advances in Skin &Amp; Wound Care

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Objective-The objective of this preliminary study was to document general somatic and wound nitric oxide (NO) levels during and after hyperbaric oxygen therapy (HBOT).Design-The study evaluated 6 chronic wound patients that responded favorably to HBOT treatment (20 treatments; 2.0 atmosphere absolute [ATA] × 90 minutes). Successful HBOT was associated with increased wound granulation tissue formation and significantly improved wound closure. Wound fluid and fasting plasma samples were obtained for measurement of nitrate and nitrite (NOx), the stable oxidation products of NO; plasma L-arginine (L-Arg); and asymmetric dimethylarginine (ADMA). NOx measurements were obtained before treatment (baseline), after 10 and 20 treatments, and at 1 and 4 weeks after therapy.Results-Wound fluid NOx levels tended to increase during treatments, were significantly elevated at 1 and 4 weeks after therapy, and correlated with reductions in wound area. Plasma L-Arg and ADMA were unchanged during and after HBOT.Conclusion-This preliminary study documents a significant increase in local wound NO levels (by NOx measurements) after successful HBOT and suggests that this mechanism may be an important factor in promoting enhanced wound healing and wound closure associated with this therapy.Hyperbaric oxygen therapy (HBOT) accelerates the healing of chronic wounds and is now primarily used as an adjunctive therapy in managing selected problem wound healing. [1][2][3][4] Hyperoxia during HBOT is an important mediating factor for wound collagen deposition and cross-linking, 5 neutrophil-dependent microbial killing, 6 and neovascularization. 7 Other HBOT-mediated processes in wound healing include the inhibition of integrin-mediated intravascular leukocyte adhesions and platelet aggregation, 8 enhancement of cutaneous microvascular homeostasis after ischemia-reperfusion syndrome, 9 increased oxygen capacitance and survival of ischemic flaps, 10 and upregulation of platelet-derived growth factor (PDGF) receptor mRNA. 11Experimental normobaric oxygen activates gene expression in human dermal fibroblasts, supporting the concept of oxygen as a possible signal transducer. 12 An additional signaling system modulated by oxygen availability is provided by the naturally occurring oxygen-free radicals (oxidants), or reactive oxygen species (ROS), found in the wound environment. ROS have been observed to increase cellular vascular endothelial growth factor (VEGF) expression and signal transduction that is considered to promote an overall enhancement of the wound healing process. 13 Further, accelerated wound healing during HBOT may be mediated by the combined effects of hyperoxia and the increased local (wound) production of nitric oxide (NO), an important cellular signal for tissue repair. 14,15 Ongoing experimental and clinical wound healing studies have established NO as a critical mediator of normal tissue repair. 16 Angiogenesis, granulation tissue formation, epidermal migration, collagen deposition, and microvascular homeostasis are signi...

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“…In this way, oxygenation of tissues is provided without requiring hemoglobin. These 2 mechanisms constitute the basis of HBO administration for treatment (15,16). Erythrocytes in bone marrow pass into circulation without nuclei or mitochondria.…”

Section: Discussionmentioning

confidence: 99%

A new utilization area for hyperbaric oxygen? Improving quality of stored blood

Ay¹,

Yüksel²,

Şimşek³

et al. 2015

Turk J Med Sci

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Background/aim: Since blood bags have the ability for diffusion of gases, we investigated whether hyperbaric oxygen (HBO) exposure affects several vital parameters of stored blood. Materials and methods:Bloods obtained from the same persons were used as both control and HBO groups and stored in pediatric bags with citrate-phosphate-dextrose solution. HBO administration was performed at 2.5 atm for 90 min, started 1 day after blood collection and repeated every 2 days for a total of 10 times. The study was terminated on the 21st day. Complete blood count, glucose, pH, and osmotic fragility values were measured every week.Results: Glucose and pH levels decreased in stored blood. In the HBO-exposed group, these decreases were less than in the control. In addition, mean corpuscular and platelet volumes tended to increase during storing process, but with HBO, these indexes remained lower, near physiologic levels. Another interesting finding of the study was the relative stable osmotic fragility ratio in the HBO group compared to the control blood. Conclusion:HBO exposure has positive effects on pH, stability of erythrocytes, and energy source (glucose) of the medium. Thus, we concluded that HBO may be a useful application for life and quality of stored blood.

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Hyperbaric oxygen and wound healing

Cited by 61 publications

References 6 publications

Topical Oxygen Emulsion

Topical Oxygen Emulsion

Hyperbaric Oxygen Therapy Mediates Increased Nitric Oxide Production Associated With Wound Healing

A new utilization area for hyperbaric oxygen? Improving quality of stored blood

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