Hyperbaric Oxygen as an Adjunctive Therapy for Bilateral Compartment Syndrome, Rhabdomyolysis and Acute Renal Failure after Heroin Intake

Abdullah, Mahdi S.; Al-Waili, Noori S.; Butler, Glenn; Baban, Nawras K.

doi:10.1016/j.arcmed.2005.07.013

Cited by 29 publications

(10 citation statements)

References 20 publications

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“…In severe acute pancreatitis, HBO 2 alleviates high spiking fever, improves white blood cell count and serum amylase levels, and reduces the abscess size [132]. Recently, we have found that HBO 2 helps to reduce edema and inflammation in compartment syndrome [133]. HBO2 had pulmonary protective effects during acute necrotizing pancreatitis [134].…”

Section: Hbo 2 and Inflammationmentioning

confidence: 99%

Effects of Hyperbaric Oxygen on Inflammatory Response to Wound and Trauma: Possible Mechanism of Action

Al-Waili¹,

Butler²

2006

The Scientific World JOURNAL

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117

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There is growing interest in expanding the clinical applications for HBO2 (hyperbaric oxygen therapy) into new medical and surgical fields. The pathophysiology of response towards wounds, infection, trauma, or surgery involves various chemical mediators that include cytokines, prostaglandins (PGs), and nitric oxide (NO). The beneficial role played by HBO2 in wound healing, carbon monoxide poisoning, decompression sickness, and other indications is well documented. However, the exact mechanism of action is still poorly understood. This review addresses the effects of HBO2 on PGs, NO, and cytokines involved in wound pathophysiology and inflammation in particular. The results of this review indicate that HBO2 has important effects on the biology of cytokines and other mediators of inflammation. HBO2 causes cytokine down-regulation and growth factor up-regulation. HBO2 transiently suppresses stimulus-induced proinflammatory cytokine production and affects the liberation of TNFα (tumor necrosis factor alpha) and endothelins. VEGF (vascular endothelial growth factor) levels are significantly increased with HBO2, whereas the value of PGE2 and COX-2 mRNA are markedly reduced. The effect of HBO2 on NO production is not well established and more studies are required. In conclusion, cytokines, PGs, and NO may play a major role in the mechanism of action of HBO2 and further research could pave the way for new clinical applications for HBO2 to be established. It could be proposed that chronic wounds persist due to an uncontrolled pathological inflammatory response in the wound bed and that HBO2 enhances wound healing by damping pathological inflammation (anti-inflammatory effects); this hypothetical proposal remains to be substantiated with experimental results.

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Section: Hbo 2 and Inflammationmentioning

confidence: 99%

Effects of Hyperbaric Oxygen on Inflammatory Response to Wound and Trauma: Possible Mechanism of Action

Al-Waili¹,

Butler²

2006

The Scientific World JOURNAL

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117

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“…A case report by Gupta in 2011 reported rhabdomyolysis associated with AKI [ 39 ]. Similarly Abdullah et al reported rhabdomyolysis and compartment syndrome in their patient who was also concomitantly using cocaine [ 40 ]. Grag et al studied the incidence and predictors of AKI in 367 cases with HCV and HIV coinfection, and reported that after adjustments, Heroin has a slightly significant HR of 1.62(1.01,- 2.60) p = 0.05, but loses statistical significance when cocaine use is subsequently added into the model with a hazard ratio (HR) of 1.28 (0.76–2.14) p = 0.35 [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Systematic review of nephrotoxicity of drugs of abuse, 2005–2016

et al. 2017

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BackgroundThe United States is faced with an unprecedented epidemic of drug abuse. Every year thousands of Americans visit the emergency departments all over the country with illicit drug related complaints. These drugs have been known to be associated with a range of renal pathologies, from reversible acute kidney injuries to debilitating irreversible conditions like renal infarction. So far, no comprehensive study or systematic review has been published that includes the commonly used street drugs and designer drugs with potential nephrotoxic outcomes.MethodsWe conducted a systematic review of published case reports, case series, and cross sectional studies of nephrotoxicities related to drugs of abuse. Literature review was conducted using PubMed/Medline from January 1, 2005 -December 31, 2016 to search for publications related to drug abuse with a defined renal outcome. Publications which reported renal injury in relation to the use of illicit drugs were selected, specifically those cases with raised creatinine levels, clinically symptomatic patients, for instance those with oliguria and proven renal biopsies.ResultsA total of 4798 publications were reviewed during the search process and PRISMA flow chart and Moose protocol regarding systematic reviews were followed. 110 articles were shortlisted for the review. A total of 169 cases from case reports and case series, and 14 case studies were analyzed. Renal manifestations of specific illicit drug abuse were included in this review.ConclusionBased on the evidence presented, a wide range of renal manifestations were found to be associated with drug abuse. If the trend of increasing use of illicit drug use continues, it will put a significant percentage of the population at an elevated risk for poor renal outcomes. This study is limited by the nature of the literature reviewed being primarily case reports and case series.

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“…The pathophysiology of rhabdomyolysis in heroin addiction includes acidosis, systemic hypoxia, muscle compression and direct toxic and immunologic effects of drug [65,66]. The heroin addicts are shown to develop severe bilateral compartment syndrome complicated by rhabdomyolysis and renal failure [67]. A recent case report has suggested that a single exposure of heroin may also lead to development of rhabdomyolysis and acute kidney injury requiring dialysis.…”

Section: Exogenous Opioids and Renal Toxicitymentioning

confidence: 99%

A Review on Renal Toxicity Profile of Common Abusive Drugs

Singh

Jaggi

2013

Korean J Physiol Pharmacol

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Drug abuse has become a major social problem of the modern world and majority of these abusive drugs or their metabolites are excreted through the kidneys and, thus, the renal complications of these drugs are very common. Morphine, heroin, cocaine, nicotine and alcohol are the most commonly abused drugs, and their use is associated with various types of renal toxicity. The renal complications include a wide range of glomerular, interstitial and vascular diseases leading to acute or chronic renal failure. The present review discusses the renal toxicity profile and possible mechanisms of commonly abused drugs including morphine, heroin, cocaine, nicotine, caffeine and alcohol.

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Hyperbaric Oxygen as an Adjunctive Therapy for Bilateral Compartment Syndrome, Rhabdomyolysis and Acute Renal Failure after Heroin Intake

Cited by 29 publications

References 20 publications

Effects of Hyperbaric Oxygen on Inflammatory Response to Wound and Trauma: Possible Mechanism of Action

Effects of Hyperbaric Oxygen on Inflammatory Response to Wound and Trauma: Possible Mechanism of Action

Systematic review of nephrotoxicity of drugs of abuse, 2005–2016

A Review on Renal Toxicity Profile of Common Abusive Drugs

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