Hyperbaric oxygen therapy in diabetic foot ulceration: Useless or useful? A battle

Löndahl, Magnus; Boulton, Andrew J.M.

doi:10.1002/dmrr.3233

Cited by 17 publications

(15 citation statements)

References 26 publications

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“…This is promising, as we have hypothesized, based on the contributing factors for wound healing discussed by Mustoe and collegues discussed 6 . In the literature there is still controversial evidence of hyperbaric medicine in woundcare 28‐33 …”

Section: Discussionmentioning

confidence: 80%

“…With respect to the EQ-5D, 147 to 150 completed questionnaires could be analyzed before and at the end of the wound treatment in the 6 In the literature there is still controversial evidence of hyperbaric medicine in woundcare. [28][29][30][31][32][33] The present study did not make use of a placebo group, and it may be argued that observed changes were due to factors other than hyperbaric oxygen treatment, which is a limitation of the current study. However, the inclusion criteria were chronic wounds that proved to be resistant to healing for a period longer than 3 months despite optimal standard wound care, and as such this functions as a benchmark or control group.…”

Section: Resultsmentioning

confidence: 99%

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Hyperbaric oxygen therapy for nonhealing wounds: Treatment results of a single center

Teguh

Raap²,

Koole³

et al. 2020

Wound Repair Regeneration

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The present article evaluates the results of the treatment with adjuvant hyperbaric oxygen therapy (HBOT) of patients with nonhealing, chronic wounds. In the period 2013 to 2016, 248 patients were referred from various hospitals because of chronic wounds that were recalcitrant in healing despite standard wound care as described in national and international guidelines. After inclusion, all patients were treated with HBOT and subjected to a weekly standard wound care treatment. During each HBOT session, 100% O2 was administered for 75 minutes under increased pressure of 2.4 ATA. Wounds and quality of life were assessed before and after the total treatment period. A total of 248 patients have been evaluated. Diabetic foot ulcers were present in 134 patients, the remainder (114 patients) showed a variety of wound locations and etiologies. The number of HBOT treatments amounted to an average of 48 (range 20‐68) sessions. Before referral to our clinic, 31% of all wounds had existed for at least 18 months (72 patients). After HBOT, 81% of all wounds were near complete healing or completely healed, in 13% of the cases the wound was stable, and in 2% minor or major amputation had to be carried out. The mean treatment time for wounds pre‐existing fewer than 6 weeks (“early referrals”) was 67 days, and 119 days for wounds pre‐existing more than 18 months (“late referrals”). A majority of the patients in our study referred with nonhealing wounds clinically improved when adjuvant HBOT was added to standard wound care protocols. No differences in success rate were seen between diabetic and nondiabetic wounds. It showed that HBOT is a well‐tolerated treatment.

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Section: Discussionmentioning

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Hyperbaric oxygen therapy for nonhealing wounds: Treatment results of a single center

Teguh

Raap²,

Koole³

et al. 2020

Wound Repair Regeneration

View full text Add to dashboard Cite

show abstract

“…For diabetic foot ulcers (DFU), 30 to 40 treatment sessions of 90 minutes are usually endorsed at pressures between 2.0 and 2.5 ATA in a hyperbaric chamber. 32 Previous high-quality RCTs showed a significant improvement in ulcer healing and decreased amputation rates among DFU patients treated with adjunctive HBOT compared to Standard care of treatment modalities alone. 33 Many preclinical and animal studies have shown that HBO stimulates angiogenesis, reduces oedema, increases the formation of granulation tissue by enhancing fibroblasts, improves leukocyte function, and mobilizes bone marrow stem cells.…”

Section: Revascularisationmentioning

confidence: 95%

A Peep in to Novel Therapies in Diabetic Foot Ulcer

Jasir¹,

Kameswaran²

2021

IJAR

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Diabetic Foot Ulcer represent a complex entity resulting from several contributing pathways including neuropathy, vascular disease, and metabolic derangement, which may occur alone or in concert with each other. DFU affects patients physically, mentally and economically. Offloading, debridement, infectious controlling and revascularization remains as the mainstay in treatment of diabetic foot. Antibiotic resistance are also observed frequently in these patients. These current standard of treatment is still not showing much recovery in patients. In this era novel approaches to the treatment of DFU gain more interest. This review aims to summarize the novel approaches that are in practice for the diabetic foot ulcer treatment along with clinical evidences from the randomized control trials. Still many procedures lack much evidence and their efficacy and safety need to be determined.

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“…90 Conclusively, HBOT is considered as an adjunctive treatment for nonhealing ischemic DFUs that do not respond to standard of care. 5,91…”

Section: Adjunct Therapiesmentioning

confidence: 99%

Nonpharmacological Management of Diabetic Foot Ulcers: An Update

Eleftheriadou

Samakidou

Tentolouris

et al. 2020

The International Journal of Lower Extremity Wounds

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Diabetic foot ulcers (DFUs) are a common and serious complication of diabetes mellitus that is associated with increased morbidity and mortality, as well as substantial economic burden for the health care system. The standard of care for DFUs includes pressure off-loading, sharp debridement, and wound moisture balance, along with infection control and management of peripheral arterial disease. A variety of advanced modalities that target distinct pathophysiological aspects of impaired wound healing in diabetes are being studied as possible adjunct therapies for difficult to heal ulcers. These modalities include growth factors, stem cells, cultured fibroblasts and keratinocytes, bioengineered skin substitutes, acellular bioproducts, human amniotic membranes, oxygen therapy, negative pressure wound therapy, and energy therapies. Additionally, the use of advanced biomaterials and gene delivery systems is being investigated as a method of effective delivery of substances to the wound bed. In the present narrative review, we outline the latest advances in the nonpharmacological management of DFUs and summarize the efficacy of various standard and advanced treatment modalities.

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Hyperbaric oxygen therapy in diabetic foot ulceration: Useless or useful? A battle

Cited by 17 publications

References 26 publications

Hyperbaric oxygen therapy for nonhealing wounds: Treatment results of a single center

Hyperbaric oxygen therapy for nonhealing wounds: Treatment results of a single center

A Peep in to Novel Therapies in Diabetic Foot Ulcer

Nonpharmacological Management of Diabetic Foot Ulcers: An Update

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