Hyperbaric Oxygen Therapy of an Adolescent Stem Cell Transplantation Recipient with Hemorrhagic Cystitis and BK Virus

López, David Gómez; Alismail, Abdullah; Tan, Laren

doi:10.1155/2020/3465412

Cited by 5 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No severe HBOT-related adverse effects were noted [16]. Case reports have reported similar promising results [17,18].…”

Section: Introductionmentioning

confidence: 84%

Untitled

2024

GJPNC

View full text Add to dashboard Cite

BK virus is one of several polyomaviruses capable of causing clinically significant infection in humans. Infection is asymptomatic, but reactivation in immunocompromised patients can cause significant clinical illness: hemorrhagic cystitis in hematopoietic stem cell transplant recipients and nephropathy in renal transplant recipients. The primary management of BK virus disease in immunocompromised patients is reduction of immunosuppression. We review the current landscape of active treatment of BK virus disease in immunocompromised patients.

show abstract

“…No severe HBOT-related adverse effects were noted [16]. Case reports have reported similar promising results [17,18].…”

Section: Introductionmentioning

confidence: 84%

Untitled

2024

GJPNC

View full text Add to dashboard Cite

show abstract

“…This also increases the solubility of oxygen so that it can reach the cells. When increased to 3 ATA, the oxygen diffusion capacity increases 4 times compared to the pressure of 1 ATA 9,10 This can save cells or tissue from hypoxia so that they can survive. When breathing normal air, the arterial oxygen pressure is approximately 100 mmHg, and the tissue oxygen pressure is approximately 55 mmHg.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Hyperbaric Oxygen Therapy (HBOT) on the Histopathological Lung Cells of Male White Wistar Rats Which are Intoxicated with Methanol

Pratiknya,

Risma R,

Bintoro

2024

Pharmacogn J.

View full text Add to dashboard Cite

Methanol is a liquid that has the characteristics of being light, very easy to evaporate, colorless, flammable, toxic, and has a very distinctive odor like ethanol but lighter. The World Health Organization (WHO) globally states that 320,000 people die every year due to methanol poisoning in the age range of around 15 years to 29 years. Usually, symptoms of poisoning caused by methanol appear within 30 minutes to 2 hours. Based on the phenomenon that occurred, the author wanted to find out more about the effect of HBOT administration on the histopathological appearance of lung cells in mice intoxicated with methanol. This study used 30 male white wistar rat lung samples aged 2 to 3 months weighing around 150 grams to 250 grams, divided into three groups, namely the control group, treatment group I, and treatment group II. The control group was not given methanol treatment and hyperbaric oxygen therapy (HBOT). Treatment group I was given methanol for 14 days without hyperbaric oxygen therapy. Meanwhile, the treatment group was given methanol for 14 days and then given hyperbaric therapy for 10 days. The results show p<0.0006, which means the data is significant and there are differences between groups. The results of this study can be concluded that administering hyperbaric oxygen therapy to rats intoxicated with methanol had a statistically significant improvement effect on the alveolar membrane, alveolar lumen, and connections between the alveoli.

show abstract

“…Local secretion of cytokines, upregulation of fibroblast growth factor (FGF), vascular endothelium-derived growth factor (VEGF) and downregulation of nitric oxide (NO) promotes vasoconstriction, angiogenesis, and urothelial repair. 49,50 Savva-Bordalo et al described clinical resolution with HBOT in 15 out of 16 patients (94%) with refractory BKV-related HC. 51 The growing body of evidence and overall safety favour HBOT as adjunctive treatment among BKV-related HC patients.…”

Section: Hyperbaric Oxygen Therapymentioning

confidence: 99%

Management of BK virus-associated haemorrhagic cystitis in allogeneic stem cell transplant recipients

Jandial

Mishra

Sandal

et al. 2021

Therapeutic Advances in Infection

View full text Add to dashboard Cite

BK virus (BKV)-related haemorrhagic cystitis (HC) is an important cause of morbidity following allogeneic haematopoietic stem cell transplantation (HSCT). The various risk factors include high-level BKV viruria and/or viremia, myeloablative conditioning, acute graft versus host disease (GVHD), cytomegalovirus viremia, and unrelated or HLA-mismatched donor. The presence of high plasma BK viral load and cytopenias have been implicated as important predictors for protracted disease course. These patients frequently require hospitalisation which may extend for several weeks. Supportive measures in the form of analgesics, intravenous hydration, bladder irrigation, and transfusion support remain the mainstay of management. Various drugs have been used with limited success in this setting. These include antiviral drugs, fluoroquinolones, leflunomide, growth factors, clotting factors, estrogens, and prostaglandins. The role of adoptive cellular immunotherapy has also been explored but lacks clinical validation. The strategies aimed at expediting urothelial repair like hyperbaric oxygen therapy (HBOT), intravesical fibrin glue and platelet-rich plasma (PRP) are emerging. Some patients with severe disease do require surgical intervention to relieve urinary obstruction. The frequent co-occurrence of acute GVHD and CMV disease further complicates the management in such patients. There is an unmet need for effective and evidence-based options for the prevention and management of this disease. Due to lack of robust data supported by randomised trials, the acceptability of the available guidelines to simplify the treatment is expected to be low. Despite the availability of various treatment options, the management of BKV-related HC in day-to-day practice continues to be a challenge. The aim of this article is to put forward an up-to-date review of the preventive and therapeutic strategies for BKV-related HC.

show abstract

Hyperbaric Oxygen Therapy of an Adolescent Stem Cell Transplantation Recipient with Hemorrhagic Cystitis and BK Virus

Cited by 5 publications

References 28 publications

Untitled

Untitled

The Effect of Hyperbaric Oxygen Therapy (HBOT) on the Histopathological Lung Cells of Male White Wistar Rats Which are Intoxicated with Methanol

Management of BK virus-associated haemorrhagic cystitis in allogeneic stem cell transplant recipients

Contact Info

Product

Resources

About